The effect of diphenylethane side-chain substituents on dibenzocyclohexadiene formation and their inhibition of α-synuclein aggregation in vitro

Nordihydroguaiaretic Acid (NDGA) Inhibits CsgA Polymerization, Bacterial Amyloid Biogenesis, and Biofilm Formation

“…We hypothesized that NDGA would inhibit the polymerization of purified soluble CsgA into amyloid fibers given its ability to inhibit polymerization and amyloid formation of human amyloidogenic proteins, specifically α-synuclein [50,51] and Aβ-40 and Aβ-42 peptides. [47][48][49] We tested this hypothesis using two biochemical assays.…”

“…NDGA has been reported to inhibit the in vitro oligomerization and fibril formation of Aβ-40 and Aβ-42 peptides [47][48][49] and inhibit polymerization of α-synuclein. [50,51] NDGA is a natural product, contributing up to 15 % of the dry mass of the leaves of the Creosote bush, Larrea tridentate. [56] The creosote bush is commonly found in the desert areas of the southwestern U.S. and northern Mexico [56] and has a long history of use in traditional medicines.…”

“…We sought to examine the possible potency of the natural product nordihydroguaiaretic acid (NDGA) [46] to inhibit curli biogenesis, inspired by its wide study in eukaryotic amyloid systems. NDGA has been reported to inhibit the in vitro oligomerization and fibril formation of Aβ‐40 and Aβ‐42 peptides [47–49] and inhibit polymerization of α‐synuclein [50,51] . NDGA is a natural product, contributing up to 15 % of the dry mass of the leaves of the Creosote bush, Larrea tridentate [56] .…”