The Effect of Different Oxygen Concentrations Used for the Induction and Maintenance of Anesthesia on Gas Exchange in the Lungs

Korkulu, Fatoş; Uysal, Hale Yarkan; Acar, H. Volkan; Eruyar, Solmaz; Dikmen, Bayazıt

doi:10.5222/jtaics.2012.011

Cited by 2 publications

(5 citation statements)

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“…SpO 2 SpO 2 was reported in 6 studies including 565 patients (Figure 4C) [17,19,20,21,22,26]. There were no significant differences in SpO 2 during recovery between two groups (MD −0.66%, 95% CI −1.57 to 0.26, p = 0.16).…”

Section: Resultsmentioning

confidence: 84%

“…AaDO 2 AaDO 2 was reported in 4 studies including 211 patients (Figure 4A) [17,21,22,24]. AaDO 2 was significantly higher in the high FiO 2 group than the low FiO 2 group (MD 3.42 mmHg, 95% CI 0.95 to 5.89, p = 0.007).…”

Section: Resultsmentioning

confidence: 93%

“…After evaluating full-text articles, 17 records were excluded because they reported no outcomes related to this study ( n = 7), performed arterial blood gas analysis during intervention ( n = 5), did not compare between high FiO 2 and low FiO 2 ( n = 4) or included lung cancer surgery ( n = 1). Finally, a total of 10 RCTs [17,18,19,20,21,22,23,24,25,26], with 787 patients, were included in final analysis (Figure 1). Among them, 391 patients were assigned to high FiO 2 group and 396 patients to low FiO 2 group.…”

Section: Resultsmentioning

confidence: 99%

“…A moderate level of heterogeneity among the studies was observed (I 2 = 62%, p = 0.01). In subgroup analysis, there were 5 studies in the endotracheal tube group [17,18,21,22,23] and 2 studies in the laryngeal mask airway group [24,25]. Each group included 213 and 142 patients, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Another reason for the heterogeneity may be attributable to ABGA being performed at different times in each study. Blood samples for ABGA were drawn at 30 min [18,24,25] or 60 min [21,25] after extubation in some studies, whereas in other studies, it was performed on the first postoperative day [17,22,23].…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Intraoperative Inspired Oxygen Fraction on Postoperative Pulmonary Parameters in Patients with General Anesthesia: A Systemic Review and Meta-Analysis

Koo

Park

Lee

et al. 2019

JCM

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High intraoperative inspired oxygen concentration is applied to prevent desaturation during induction and recovery of anesthesia. However, high oxygen concentration may lead to postoperative pulmonary complications. The purpose of this study is to compare the postoperative pulmonary parameters according to intraoperative inspired oxygen fraction in patients undergoing general anesthesia. We identified all randomized controlled trials investigating postoperative differences in arterial gas exchange according to intraoperative fraction of inspired oxygen (FiO2). A total of 10 randomized controlled trials were included, and 787 patients were analyzed. Postoperative PaO2 was lower in the high FiO2 group compared with the low FiO2 group (mean difference (MD) −4.97 mmHg, 95% CI −8.21 to −1.72, p = 0.003). Postoperative alveolar-arterial oxygen gradient (AaDO2) was higher (MD 3.42 mmHg, 95% CI 0.95 to 5.89, p = 0.007) and the extent of atelectasis was more severe (MD 2.04%, 95% CI 0.14 to 3.94, p = 0.04) in high intraoperative FiO2 group compared with low FiO2 group. However, postoperative SpO2 was comparable between the two groups. The results of this meta-analysis suggest that high inspired oxygen fraction during anesthesia may impair postoperative pulmonary parameters. Cautious approach in intraoperative inspired oxygen fraction is required for patients susceptible to postoperative pulmonary complications.

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