The Effect of Different Levels of Coriander Oral Administration on Hepatocellular Carcinoma in Rats

Abstract

Background: Coriander (Coriandrum sativum L.) is grown as a spice crop all over the world. A few articles have linked the consumption of coriander to certain liver diseases but several articles have disputed these assertions and the consumption of coriander has been on the increase. Objective: This study aimed to determine the effects of oral administration of coriander on hepatocellular carcinoma in rats in order to compare biochemical findings with histological findings. Materials and Methods: Forty male and female albino rats were grouped into 5, consisting of 8 rats in each group. Group (1) was fed on the basal diet and tab water as a negative control group, while the other groups were fed on basal diet and injected with C. Diethyl Nitrosamine (DEN) to induce hepatocellular carcinoma in rats. Group (2) was left as a positive control, while groups (3), (4), and (5) were fed on experimental diets and oral administration of 1 g, 3 g, and 6 g of the Coriander, respectively, for 6 weeks.Their blood samples were analyzed for total and conjugated bilirubin, total protein, albumin, globulin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. The liver tissues were also processed for histological examination. Results: Examination of livers obtained from hepatocarcinogenesis rats in high concentration extract of coriander (6g) group revealed the best results compared with the other treatment groups in hepatic lobules. Conclusion:This study suggests that oral administration of coriander seed in high levels concentration extract for 6 weeks may be beneficial for patients suffering from hepatocarcinogenesis and liver disease as it improves liver function.