The Effect of Different Levels of Flaxseed Oil on Biochemical Changes in Hypercholesterolemic Rats

Abstract

Flaxseed oil has various benefits over multiple chronic diseases in humans and animals. Besides, flaxseed oil has shown the potential to avert lipid disorders. However, various researches have indicated that lower serum cholesterol in animals and human beings can be attributed to whole flaxseed oil. Therefore, this study aimed at determining the effect of different levels of flaxseed oil on biochemical changes in hypercholesterolemic rats. In this study, (24) albino mice were used and divided into two main groups. The first was a group of mice infected with hypercholesterolemia, the second negative control group was a group of non-infected mice. They were then divided into four groups with two of them given different concentrations of flaxseed oil (20% and 25%). Of the other two groups, one positive infected and another uninfected negative control group were not kept on the experimental diet meaning that all mice were divided into 4 groups consisting of 6 mice in each group. The result showed that non-significant differences in HDL levels between 20%, 25% flaxseed oil and control negative when compared with control positive Also, there were significant decreases in ALP between the groups replaced with different percentage of flaxseed oil compared with control (+) group. The results suggest to use different levels of flaxseed oil for hypercholesterolmic patients, also suggests future studies may be to evaluate the efficacy and advantage of using flaxseed oil as extracts.