The Effect of Different Fluoride Concentrations and pH of Dentifrices on Plaque and Nail Fluoride Levels in Young Children

Buzalaf, Marília Afonso Rabelo; Vilhena, Fabiano Vieira; Iano, Flávia Godoy; Grizzo, Larissa Tercília; Pessan, Juliano Pelim; Sampaio, F. C.; Oliveira, Rodrigo Cardoso de

doi:10.1159/000211717

Cited by 27 publications

(34 citation statements)

References 28 publications

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“…All dentifrices presented NaF as F compound with silica as abrasive. The composition of the liquid dentifrices is in accordance with a previous study . The liquid dentifrices have the consistency of a gel, but with more fluidity.…”

Section: Methodssupporting

confidence: 86%

“…On the other hand, the reduction of the pH and change of consistency (from paste to liquid or gel) has been shown to be effective in increasing plaque fluoride uptake in vivo . Acidic dentifrices with 550 ppm F have the same effectiveness as neutral 1100 ppm F dentifrices in reducing enamel demineralization in vitro and caries progression in vivo …”

Section: Introductionmentioning

confidence: 99%

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Impact of different fluoride concentrations and pH of dentifrices on tooth erosion/abrasion in vitro

Moron

Miyazaki

Ito

et al. 2013

Australian Dental Journal

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Background: This in vitro study analysed the effect of different fluoride concentrations in acidic or neutral liquid dentifrices in protecting enamel and dentine from erosive and abrasive wear. Methods: Bovine enamel and dentine specimens (n = 132) were randomly allocated to 11 groups (each n = 12): experimental liquid dentifrices with 550 ppm F, 1100 ppm F, 5000 ppm F or 0 ppm F/placebo (each at pH 4.5 and pH 7.0); and commercial dentifrices with 550 ppm F (Colgate Baby, pH 7.0), 1100 ppm F (Crest, pH 7.0) and 5000 ppm F (Duraphat, pH 7.0). The specimens were subjected to erosion for 90 seconds, 4 times/day, over 7 days. Immediately after the first and last erosion, the specimens were brushed for 15 seconds using one of the dentifrices. Tooth wear was measured profilometrically (lm) and analysed by ANOVA (p < 0.05). Results: All fluoridated liquid dentifrices significantly reduced enamel wear compared to the placebo and commercial dentifrices. Only liquid dentifrices with 1100 and 5000 ppm F significantly reduced dentine wear compared to placebo dentifrice. The pH had no effect, but the consistency had a significant impact on the effect of dentifrices. Conclusions: Liquid dentifrices with high F concentration appear to be a good option to prevent tooth wear.

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Section: Methodssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Impact of different fluoride concentrations and pH of dentifrices on tooth erosion/abrasion in vitro

Moron

Miyazaki

Ito

et al. 2013

Australian Dental Journal

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“…Low-fluoride (500 ppm) acidic (pH 4.5 or 5.5) NaF dentifrices have been shown in pH-cycling studies to be as effective as 1,100 ppm F neutral NaF dentifrices. This was confirmed in clinical studies showing that a 550 ppm F pH 4.5 dentifrice led to similar plaque fluoride concentrations as the 1,100 ppm F pH 7.0 dentifrice 12 and that both dentifrices led to similar caries increments in a 20-month clinical trial with 4-5-year-old children (unpublished date).…”

Section: Results and Literature Reviewmentioning

confidence: 54%

pH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations

et al. 2010

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Despite a plethora of in situ studies and clinical trials evaluating the efficacy of fluoridated dentifrices on caries control, in vitro pH cycling models are still broadly used because they mimic the dynamics of mineral loss and gain involved in caries formation. This paper critically reviews the current literature on existing pH-cycling models for the in vitro evaluation of the efficacy of fluoridated dentifrices for caries control, focusing on their strengths and limitations. A search was undertaken in the MEDLINE electronic journal database using the keywords "pH-cycling", "demineralization", "remineralization", "in vitro", "fluoride", "dentifrice". The primary outcome was the decrease of demineralization or the increase of remineralization as measured by different methods (e.g.: transverse microradiography) or tooth fluoride uptake. Inclusion of studies, data extraction and quality assessment were undertaken independently and in duplicate by two members of the review team. Disagreements were solved by discussion and consensus or by a third party. One hundred and sixteen studies were included, of which 42 addressed specifically the comparison of dentifrices using different pH-cycling models. The other studies included meta-analysis or reviews, data about the effect of different fluoride sources on de-remineralization, different methods for analysis de-remineralization and chemical variables and characteristics of dental hard tissues that might have influence on de-remineralization processes. Generally, the studies presented ability to detect known results established by clinical trials, to demonstrate dose-related responses in the fluoride content of the dentifrices, and to provide repeatability and reproducibility between tests. In order to accomplish these features satisfactorily, it is mandatory to take into account the type of substrate and baseline artificial lesion, as well as the adequate response variables and statistical approaches to be used. This critical review of literature showed that the currently available pH-cycling models are appropriate to detect dose-response and pH-response of fluoride dentifrices, and to evaluate the impact of new active principles on the effect of fluoridated dentifrices, as well as their association with other anti-caries treatments.

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“…Since dental caries has become a polarized disease and conventional fluoride therapy seems to have little effect for highrisk groups [Pessan et al, 2008], alternatives have been proposed to increase the effectiveness of fluoridated vehicles Buzalaf et al, 2009;Takeshita et al, 2009;Vilhena et al, 2010;Amaral et al, 2013]. All fluoride varnishes tested in the present study were shown to significantly increase remineralization of enamel carious lesions, following a dose-response relationship.…”

Section: Discussionmentioning

confidence: 65%

In vitro Remineralizing Effect of Fluoride Varnishes Containing Sodium Trimetaphosphate

et al. 2014

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This study analyzed the effects of fluoride varnishes supplemented with sodium trimetaphosphate (TMP) on the remineralization of caries-like lesions in vitro. Bovine enamel discs were selected through surface hardness (SH) and caries-like lesions were induced. SH was again determined and the blocks were divided into 7 experimental groups (n = 24/group): placebo (no fluoride or TMP), 5% TMP, 2.5% NaF, 2.5% NaF/5% TMP, 5% NaF, 5% NaF/5% TMP and commercial formulation (Duraphat™, 5% NaF), following a blind protocol. Discs were treated with the varnishes and kept in a remineralizing solution for 4 h and a demineralizing solution for 2 h. Varnishes were then removed and half of the discs were used for analysis of loosely (CaF₂) and firmly bound fluoride. The remaining discs were submitted to a pH-cycling regimen for 6 days. The percentage of surface hardness recovery (%SHR), cross-sectional hardness (ΔKHN) and enamel CaF₂ and fluoride were determined. Data were analyzed by ANOVA and by Student-Newman-Keuls' test (p < 0.05). A dose-response relationship was observed between fluoride concentrations in the varnishes and %SHR. The 5% TMP varnish led to %SHR similar to that obtained for the placebo. When TMP was used in association with fluoride, however, significantly higher %SHR were observed in comparison with their counterparts without TMP. Moreover, ΔKHN obtained for the 5% NaF/5% TMP was significantly lower among all groups tested. Higher concentrations of CaF₂ and fluoride were observed for Duraphat and 5% NaF, followed by 5% NaF/5% TMP, 2.5% NaF and 2.5% NaF/5% TMP (p < 0.05). It was concluded that the supplementation of fluoride varnishes with TMP leads to enhanced remineralizing effect of artificial caries lesions in vitro.

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The Effect of Different Fluoride Concentrations and pH of Dentifrices on Plaque and Nail Fluoride Levels in Young Children

Cited by 27 publications

References 28 publications

Impact of different fluoride concentrations and pH of dentifrices on tooth erosion/abrasion in vitro

Impact of different fluoride concentrations and pH of dentifrices on tooth erosion/abrasion in vitro

pH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations

In vitro Remineralizing Effect of Fluoride Varnishes Containing Sodium Trimetaphosphate

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