The effect of different doses of propofol on tracheal intubating conditions without muscle relaxant in children

Effects of graded doses of propofol for anesthesia induction on cardiovascular parameters and intraocular pressures in normal dogs

“…In both studies, blood pressure and respiratory depression were measured by indirect methods. In people, increasing doses of propofol for induction have not been associated with significantly different blood pressure readings but do improve conditions for intubation (Braga et al. 2001; Gupta et al.…”

Influência dos Hipnóticos no bloqueio neuromuscular produzido pelo cisatracúrio: emprego da aceleromiografia

“…The lower incidence of cough seen in the propofol group (two patients with mild cough) compared to the etomidate group (vigorous cough in 14 patients) may be due to the greater depressant action of propofol on pharyngeal-laryngeal refl exes 15,[17][18] . Propofol is able to decrease the reactivity of larynx and pharynx muscle tone and enable tracheal intubation without neuromuscular blockers 8,13,[16][17][18][19][20] . However, there are no reports in literature concerning its direct action on vocal cords.…”

“…This time interval can be infl uenced by factors, such as hypnotics and those associated with neuromuscular block monitoring (e.g., time to muscle stabilization, control, and frequency of stimulation used) [1][2][3][4][5] . Among drugs used in anesthesia, some hypnotics have certain peculiarities and different mechanisms, with may interfere with muscle relaxation induced by nondepolarizing neuromuscular blockers (NDNMB) 5,[6][7][8] . Among benzylisoquinolinic neuromuscular blockers, cisatracurium has a highly selective affi nity to the motor endplate, which may explain the absence of autonomic ganglion and vagal effects and the low potential for histamine release.…”

Influência do propofol e do etomidato no bloqueio neuromuscular produzido pelo rocurônio: avaliação pela aceleromiografia

“…O propofol, além de diminuir a reatividade do tônus muscular da laringe e da faringe, possibilitando a intubação traqueal sem o uso de bloqueadores neuromusculares, quando empregado em doses semelhantes às utilizadas na clínica, tem in vitro ação sobre a junção neuromuscular, reduzindo o tempo de abertura do canal do receptor nicotínico muscular [7][8][9][10] . O objetivo deste estudo foi avaliar comparativamente a influência do propofol e do etomidato na instalação do bloqueio neuromuscular, produzido pelo rocurônio.…”

“…Rocuronium is a fast onset nondepolarizing NMB Some hypnotics, such as etomidate, have certain peculiarities which, due to their hemodynamic stability, may contribute for a shorter non-depolarizing NMB onset 6 . Propofol, in addition to decreasing laryngeal and pharyngeal muscle tone reactivity allowing tracheal intubation without neuromuscular blockers when used in doses similar to those used in the clinic, has an in vitro action on the neuromuscular junction and decreases muscle nicotinic receptor channel opening [7][8][9][10] . This study aimed at comparing the influence of propofol and etomidate in rocuronium-induced neuromuscular block.…”