The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action

Grosso, Giuseppe; Godos, Justyna; Currenti, Walter; Micek, Agnieszka; Falzone, Luca; Libra, Massimo; Giampieri, Francesca; Forbes‐Hernández, Tamara Y.; Quiles, José L.; Battino, Maurizio; Vignera, Sandro La

doi:10.3390/nu14030545

Cited by 73 publications

(62 citation statements)

References 116 publications

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“…A large body of evidence supports the intake of natural nutrients such as polyphenols [ 32 ] and antioxidant vitamins [ 33 ], as well as dietary patterns such as the Mediterranean diet [ 34 ], Dietary Approaches to Stop Hypertension [ 35 ], the Nordic Diet [ 36 ], and Traditional Asian Diets [ 37 , 38 , 39 ], can prevent CVDs. The findings of three large prospective cohorts with up to 32 years of follow-up showed that greater adherence to various healthy eating patterns was associated with a lower risk of CVD [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

et al. 2022

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This study aimed to assess the relationship between the dietary total antioxidant capacity (DTAC) and the occurrence of cardiovascular diseases (CVDs), as well as healthy diet quality, in a representative sample (n = 5690) of the whole Polish adult population (WOBASZ II study). Daily food consumption was estimated by the single 24 h dietary recall method. Antioxidant vitamins (C, E, and β-carotene) and minerals (Zn, Fe, Mn, and Cu) from the diet and supplements were calculated using 5D Diet software, and dietary total polyphenol intake (DTPI) was determined using the Phenol-Explorer database and our database. Total diet quality was measured by the Healthy Diet Indicator (HDI) based on World Health Organization (WHO) recommendations for the prevention of CVD. DTAC was calculated using the data on food consumption and the antioxidant potential of foods measured by the FRAP (ferric ion reducing antioxidant potential) method. It was shown that higher DTAC was associated with a higher intake of polyphenols, antioxidant vitamins, and minerals. Moreover, a higher quartile of DTAC was associated with a reduced odds ratio for cardiovascular diseases in a Polish population, as well as with a higher HDI. Therefore, dietary recommendations for the prevention and therapy of CVDs should take into account a high DTAC. DTAC, measured by the FRAP method, can be considered an indicator of healthy diet quality.

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Section: Discussionmentioning

confidence: 99%

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

et al. 2022

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“…Within berries, there are three classes of polyphenols in particular that may account for a beneficial effect on BP: anthocyanins, condensed tannins and ellagic acid [8].…”

Section: Berry Polyphenols and Blood Pressurementioning

confidence: 99%

“…However, while this nutritional profile is common to most fruits and vegetables, the specific effect proposed for berries on BP must involve further features, acting in addition or synergistically to the above mentioned ones. What is distinctive to berries is the presence of a number of phytochemicals within the family of polyphenols [8].…”

Section: Introductionmentioning

confidence: 99%

The Role of Berry Consumption on Blood Pressure Regulation and Hypertension: An Overview of the Clinical Evidence

Vendrame

Adekeye

2022

Nutrients

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The existence of a relationship between the consumption of dietary berries and blood pressure reduction in humans has been repeatedly hypothesized and documented by an increasing body of epidemiological and clinical evidence that has accumulated in recent years. However, results are mixed and complicated by a number of potentially confounding factors. The objective of this article is to review and summarize the available clinical evidence examining the effects of berry consumption on blood pressure regulation as well as the prevention or treatment of hypertension in humans, providing an overview of the potential contribution of distinctive berry polyphenols (anthocyanins, condensed tannins and ellagic acid), and results of dietary interventions with blueberries, bilberries, cranberries, raspberries, strawberries, chokeberries, cherries, blackcurrants and açai berries. We conclude that, while there is insufficient evidence supporting the existence of a direct blood pressure lowering effect, there is stronger evidence for specific types of berries acting indirectly to normalize blood pressure in subjects that are already hypertensive.

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“…Flavanone hesperetin, in combination with sodium cyclic lysophosphatidic acid, showed significant antiaging effects on skin hydration and elasticity in a single-center clinical trial [ 23 ]. In general, data from several studies suggest that higher dietary intake of flavonoids may be associated with better cognitive health [ 24 , 25 ], improved prognosis for cardiovascular diseases [ 26 , 27 ], and decreased body weight [ 28 ]. Taken together, due to antioxidant activity, selective affinity to several biological targets, and high safety profiles, flavonoids are a prospective class of natural compounds for drug development [ 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Pharmacological Effects of Flavonoids: The Systematic Review of Computer Modeling

Taldaev

Terekhov

Nikitin

et al. 2022

IJMS

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Computer modeling is a method that is widely used in scientific investigations to predict the biological activity, toxicity, pharmacokinetics, and synthesis strategy of compounds based on the structure of the molecule. This work is a systematic review of articles performed in accordance with the recommendations of PRISMA and contains information on computer modeling of the interaction of classical flavonoids with different biological targets. The review of used computational approaches is presented. Furthermore, the affinities of flavonoids to different targets that are associated with the infection, cardiovascular, and oncological diseases are discussed. Additionally, the methodology of bias risks in molecular docking research based on principles of evidentiary medicine was suggested and discussed. Based on this data, the most active groups of flavonoids and lead compounds for different targets were determined. It was concluded that flavonoids are a promising object for drug development and further research of pharmacology by in vitro, ex vivo, and in vivo models is required.

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The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action

Cited by 73 publications

References 116 publications

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

The Role of Berry Consumption on Blood Pressure Regulation and Hypertension: An Overview of the Clinical Evidence

Insights into the Pharmacological Effects of Flavonoids: The Systematic Review of Computer Modeling

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