The effect of dietary nitrate on macro- and microvascular function: A systematic review

Volino-Souza, Mônica; Oliveira, Gustavo Vieira de; Pinheiro, Vivian dos Santos; Conté-Júnior, Carlos Adam; Álvares, Thiago Silveira

doi:10.1080/10408398.2022.2113989

Cited by 3 publications

(2 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This outcome diverges from the findings of previous research [60][61][62][63][64] which highlighted the potential of beetroot to support cardiovascular health. However, it is important to note that the absence of significant changes in our study does not negate the cardiovascular benefits of beetroot identified in earlier studies [30,65]. The variability in blood pressure responses to dietary nitrate may be influenced by a participant's initial blood pressure levels [66].…”

Section: Discussionmentioning

confidence: 50%

“…A standardized aqueous beetroot extract (SABEET™, Sabinsa Corporation, East Windsor, NJ, USA) (BET) containing at least 2% nitrate was used in the present study, with the studied batch containing 2.74% nitrate (approximately 548 mg or 8.8 mmol nitrate/day). This amount was chosen based on previous studies demonstrating health benefits after consumption of beetroot supplementation [ 12 , 30 ]. The PLA intervention was prepared by the manufacturer by removing nitrate from the BET.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of 12-Week Standardized Beetroot Extract Supplementation in Older Participants: A Preliminary Study of Human Health Safety

Pinheiro,

Junior,

Ortmann

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

In recent years, there has been a notable surge in the popularity of beetroot-based dietary supplements, driven by their rich nitrate composition. Several types of beetroot-based dietary supplements can be found in markets worldwide; however, ensuring the safety of dietary supplements is a crucial consideration, as there is limited evidence on their safety, especially for older populations. Therefore, the purpose of the current study was to evaluate the safety and tolerability of a nitrate-rich beetroot extract in older participants taking supplements over 12 weeks. The participants were randomly assigned to receive 20 g daily of beetroot extract or a matching placebo. The safety and tolerability of the supplementation were evaluated as the occurrence of adverse events and anthropometric, biochemical, and hemodynamic parameters were measured. No serious adverse events were reported in any group. Anthropometric, biochemical, and hemodynamic parameter changes between the baseline and the end of the study were not statistically significant in either group. However, interestingly, the group receiving beetroot extract supplementation exhibited a notable increase in plasma nitrate levels (p = 0.076, f = 0.50) and showed a decrease in insulin levels (p = 0.026, f = 0.59). In conclusion, we found that 20 g of beetroot extract supplementation for 12 weeks was safe and well tolerated in older participants.

show abstract