The effect of dietary ingestion of oxalic acid on thyroid function in male and female Long-Evans rats

Goldman, Max; Doering, Gregory J.

doi:10.1016/0041-008x(79)90424-1

Cited by 10 publications

(2 citation statements)

References 24 publications

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“…PCBs and their hydroxylated metabolites, as well as hexachlorobenzene and its metabolite pentachlorophenol, have been shown to reduce circulating levels of total thyroxine and free thyroxine and in some cases to increase thyroidstimulating hormone concentrations in both pregnant and nonpregnant animals (26)(27)(28). Although effects of DDT and DDE on thyroid hormone concentrations were not demonstrated in experimental studies conducted in mammals (29), a decrease in iodine uptake by the thyroid gland was observed after acute exposure to technical DDT in rats (30).…”

mentioning

confidence: 99%

Effects of Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides on Thyroid Function during Pregnancy

Chevrier

Eskenazi

Holland

et al. 2008

American Journal of Epidemiology

117

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In this study, the authors' objective was to determine whether serum concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene, p,p'-dichlorodiphenyl trichloroethane (DDT), o,p'-DDT, and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnancy. These compounds, as well as thyroid-stimulating hormone, total thyroxine, and free thyroxine, were measured in serum samples collected between October 1999 and October 2000 from 334 pregnant women living in the Salinas Valley, California. Data were analyzed by multivariate linear regression. After adjustment for covariates, seven of the 19 PCB congeners detected in more than 75% of participants and the sum of those congeners were negatively associated with free thyroxine concentrations. PCBs 44, 52, and 183 remained significant after the exclusion of two outliers. Hexachlorobenzene concentrations were negatively associated with both free thyroxine and total thyroxine. PCB and hexachlorobenzene concentrations were strongly correlated, which hampered the authors' ability to identify their independent associations with thyroid function. None of the exposures under study were associated with thyroid-stimulating hormone. Results suggest that exposure to PCBs and/or hexachlorobenzene at background levels may affect thyroid function during pregnancy. These findings are of particular significance, since thyroid hormones of maternal origin may play an essential role in fetal neurodevelopment.

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confidence: 99%

Effects of Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides on Thyroid Function during Pregnancy

Chevrier

Eskenazi

Holland

et al. 2008

American Journal of Epidemiology

117

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“…Regarding the effect of DDT and its metabolites, several studies performed on animal models showed, in general terms, a hypothyroid like effect (Goldman, 1981;Grässle and Biessmann, 1982;Capen, 1992). Recently, studies in Sprague-Dawley rats have shown that p,p'-DDE exposure significantly reduced total thyroxine (TT4), free thyroxine (FT4) and transthyretin serum levels, accompanied by elevated mRNA expression in α1 and β1 thyroid hormone receptors in the hypothalamus (Liu et al, 2011).…”

Section: Introductionmentioning

confidence: 97%

Association between organochlorine pesticide exposure and thyroid hormones in floriculture workers

Blanco-Muñoz

Lacasaña

López-Flores

et al. 2016

Environmental Research

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Aliphatic Carboxylic Acids: Saturated

2023

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Aliphatic carboxylic acids (ACA) include many chemicals with a wide range of biological and industrial functions. Many are nutritionally important, occur naturally, and take part in normal biochemical processes. ACA are commercially important with annual production of over 3, 1, and 1 billion lbs/year for acetic, formic, and acrylic acids alone, respectively. Generally, ACA are of no serious concern, except at very high levels of experimental or accidental exposures, many are designated as GRAS. Primary adverse effects are irritation to skin, eyes, and mucous membranes from acute exposures to strong water‐soluble acids that can penetrate the skin or those that can volatilize like short‐chain formic, acetic, and propionic acids; dermal sensitization is rare. Saturated ACA are used in a variety of applications, such as in the production of synthetic fiber, resins, plastics, and dyes. Several acids and their esters are important chemical intermediates or solvents and are used in cosmetics or food applications as pH modifiers, preservatives, and antioxidants. Saturated, straight‐chain monocarboxylic acids are metabolized by the β‐oxidation pathway until acetate, propionate, or butyrate are formed which are utilized for energy production via TCA cycle or converted to acetoacetate and subsequently to other ketone bodies, which can be oxidized or excreted in the urine. Propionate originates from odd‐chain acids and is converted to carbohydrates and, unlike acetate, into lipids. This chapter covers 33 ACA their toxicity and workplace exposure limits under a number of regulatory agencies based on the available data.

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The effect of dietary ingestion of oxalic acid on thyroid function in male and female Long-Evans rats

Cited by 10 publications

References 24 publications

Effects of Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides on Thyroid Function during Pregnancy

Effects of Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides on Thyroid Function during Pregnancy

Association between organochlorine pesticide exposure and thyroid hormones in floriculture workers

Aliphatic Carboxylic Acids: Saturated

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