The effect of diet and 1,1,1-trichloro-2,2-bis-(<i>p</i>-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning

McLean, A. E. M.; McLean, Elspeth

doi:10.1042/bj1000564

Cited by 299 publications

(56 citation statements)

References 13 publications

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“…In Groups 8-11 the treatment losarcomata and thymomata), the nasal with saline, DMN and ACT alone or DMN and paranasal cavities (papillomata, and ACT 9 h later were combined with a squamous and adenocarcinomata, estheprotein deficient diet (Hope Farms RMH-sioneuroepitheliomata), the heart (neu-TMB/ McLean and McLean, 1966). The diet rofibromata and one neurofibrosarcoma), was given 1 week before and 1 week after the adrenal gland (cortical adenomata) as treatment.…”

Section: Resultsmentioning

confidence: 99%

The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro

McNally¹

1975

Br J Cancer

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Summary.-The effect of a single treatment with 30 mg dimethylnitrosamine (DMN) and 6 ,ug actinomycin D (ACT), given at different time intervals (ACT application to DMN, 2 h before, simultaneously, 5, 9 or 48 h later), was tested in female Sprague-Dawley rats in relation to renal carcinogenesis; additionally, the animals were fed either a normal or a protein deficient diet.The ACT treatment did not significantly modify either the kidney tumour incidence or the survival time in the different groups fed a normal diet. Nevertheless, there are indications that additional ACT application may shorten the latency period for DMN induced renal neoplasms or, when administered 5 h later than DMN, a slightly decreased and delayed tumour induction can be assumed. In groups fed a protein deficient diet, a significantly higher percentage of kidney tumour bearing animals as well as a shortened latency period were found when compared with the DMN group on normal diet, but these differences were independent of the additional ACT treatment 9 h later than DMN and were due to the protein deprivation. Morphologically, the tumours were of epithelial and mesenchymal type with a clear preponderance of the former type. Biochemical and morphological aspects are discussed.

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Section: Resultsmentioning

confidence: 99%

The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro

McNally¹

1975

Br J Cancer

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“…He observed that the toxicity of carbon tetrachloride in rats fed low or non-protein diets was decreased, since the activation of carbon tetrachloride to an active hepatoxic agent might be decreased in these rats (23). Moreover, the liver weight to body weight ratio was greater in the rats fed the high protein diet than in the rats fed the low or non protein diets.…”

Section: Discussionmentioning

confidence: 99%

Toxicity and Metabolism of Drugs in Relation to Dietary Protein

Kato

Oshima

Tomizawa

1968

Japanese Journal of Pharmacology

117

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It was demonstrated that the toxicities of various drugs are often related to the rate of metabolism of the drugs and to the activity of drug-metabolizing enzymes of liver micro somes (1-6). In a previous paper, it was briefly reported that the oxidation of pento barbital, strychnine and meprobamate was markedly decreased in the immature female rats by the feeding on low protein diet or non-protein diet (7).The purpose of present study is to investigate the effect of high and low protein diet on the toxicities of various drugs in relation to the drug-metabolizing activities of liver microsomes, and to investigate whether the alternation in the drug-metabolizing activities may be correlated to the activities of microsomal NADPH-linked electron transport system.Since there are marked sex differences in the alternations in the activities of drug metabolizing enzymes in the rats under some unphysiological states, the effect of diets of different protein contents on the toxicity and metabolism of drugs was comparatively investigated in male and female rats (8-12). METHODSMale and female rats of Wistar strain, weighing about 170 g and 150 g, respectively, were used. The rats were fed diets of 50%, 18%, 10% or 5% protein content for 2 weeks or fed non-protein diet for 4 days before sacrifice. The composition of the standard diet was as follows: 18% casein, 300/ corn starch, 15% glucose, 10% sucrose, 10% corn oil, 10% wood pulp and salt mixture and vitamins.The diets of various protein content were made by changing the content of casein with glucose.The toxicities of strychnine, octamethylpyrophosphoramide (OMPA), pentobarbital and zoxazolamine were determined by the intraperitoneal injection of the drugs. The metabolism in vivo of pentobarbital was determined by measuring the rate of decrease in the concentration of pentobarbital in the serum and brain.

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“…Animals.-Wistar-derived male rats of CFN stock (5-6 wNeeks old; 130-140 g) were bought from Carworth Farms, New City, N.Y., U.S.A. After 5-7 days' acclimatization, during which they were fed Purina Chow (Ralston Purina Corp., St Louis, Mo., U.S.A.), they were changed to a semi-synthetic diet containing no protein (McLean & McLean, 1966). Those rats to be treated were weighed and given an i.p.…”

Section: Methodsmentioning

confidence: 99%

Induction of kidney tumours by a single dose of dimethylnitrosamine: dose response and influence of diet and benzo(a)pyrene pretreatment

Swann¹,

Kaufman²,

Magee³

et al. 1980

Br J Cancer

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Summary.-Seven days on a protein-free diet increases the susceptibility of rats to the action of DMN as a renal carcinogen. The dose response for the induction of kidney tumours by a single dose of dimethylnitrosamine (DMN) in these rats is reported. The first tumour was not found until 28 weeks after the dose. At 100 weeks the incidence ranged from 22.50/o at the lowest dose (20 mg/kg) to 97°h at the highest dose (60 mg/kg). The incidence in probits at any time between 50 and 100 weeks was linearly related to the log dose. Epithelial and mesenchymal tumours were produced in an approximate ratio of 2:1. The protein -free diet alters the rate of metabolism of DMN in the rat, and increases the alkylation of nucleic acids by this carcinogen in the kidney. Further treatment of the rat with benzo(a)pyrene can reverse, to some extent, the change in metabolism, but does not reverse the change in alkylation. It is shown that the change in kidney-tumour incidence produced by the change in diet, and by the treatment with benzo(a)pyrene, corresponds to the changes these treatments produce in the alkylation of kidney DNA by the carcinogen.

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The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning

Cited by 299 publications

References 13 publications

The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro

The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro

Toxicity and Metabolism of Drugs in Relation to Dietary Protein

Induction of kidney tumours by a single dose of dimethylnitrosamine: dose response and influence of diet and benzo(a)pyrene pretreatment

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