The Effect of Dicumarol (3,3'-Methylenebis [4-Hydroxycoumarin]) on Platelet Adhesiveness

Spooner, Maryloo; Meyer, Ovid O.

doi:10.1152/ajplegacy.1944.142.2.279

Cited by 35 publications

(8 citation statements)

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“…These findings agree with those of some investiga-tors, 4 ' ° but conflict with those of others. 8 ' 9 In Sharp's 8 observations made on 4 patients, the anticoagulant therapy was regulated by the prothrombin time.…”

Section: Dicumarol Therapy and Platelet Functionsupporting

confidence: 84%

“…Some investigators have found that administration of these drugs to patients and animals makes platelets less adhesive. 4 " 6 Since platelet adhesiveness appears to be related to the onset of platelet clumping, 7 one might expect that the formation of platelet clumps would be delayed during Dicumarol therapy. Although this has been observed in animal experiments, 1 ' 2 a study of human subjects receiving "Dindevan" therapy, showed no such delay.…”

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confidence: 99%

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Dicumarol Therapy

Murphy

Mustard

1960

Circulation Research

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One of the problems of Dicumarol administration has been determination of the adequacy of therapy. A fundamental stage in thrombus formation in the circulation is platelet clumping. Since platelets are involved in both hemostasis and thrombosis, a study of changes in platelet function may prove useful. The effects of Dicumarol on platelet clumping and adhesiveness have, therefore, been studied and related to changes in other clotting mechanisms. Comparison of platelet function in control periods and during Dicumarol administration shows that this drug lowers the adhesive index and prolongs the platelet clumping time to a highly significant degree. The accuracy of estimates of these 2 platelet functions given by 3 other tests, prothrombin time, whole blood clotting time and plasma activity in the thromboplastin generation tests have been compared. By any criterion, degree of correlation, consistency of regression slopes, intercepts or scatter about regression lines, clotting time was the most efficient of the 3 tests for evaluting platelet function. The prothrombin time was the least efficient. Furthermore, hemorrhage from excessive dosage was closely related to the platelet clumping time and clotting time. It should be pointed out, however, that in about one-third of the patients the prothrombin time was as good an index of platelet clumping time as clotting time. While prothrombin times done with 2 different sources of thromboplastin may give congruous results in untreated patients, considerable discrepancies may appear during Dicumarol therapy. If prothrombin time is to be used as a guide to Dicumarol therapy, it is important to establish in each patient separately its reliability as a measure of the behavior of the clotting mechanism as a whole. For those in whom it seems reliable, an individual "therapeutic range" should be determined. For other cases, some other suitable test should be employed. It is emphasized that regulation of Dicumarol dosage is an individual problem and that only those tests shown to be reliable indices of safe effective modifications of clotting mechanism in the individual patient should be used.

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Section: Dicumarol Therapy and Platelet Functionsupporting

confidence: 84%

mentioning

confidence: 99%

Dicumarol Therapy

Murphy

Mustard

1960

Circulation Research

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“…She has also found that anticoagulants, such as heparin and chlorazol-fast pink, decrease the adhesion of platelets as measured by her method. A similar decrease of platelet adhesion following dicoumarin adminis-tration has been observed by Spooner and Meyer (1944). The nature of platelet adhesion is at present unknown.…”

Section: Hcreditarysupporting

confidence: 71%

Normal and Abnormal Blood Coagulation: A Review

Macfarlane¹

1948

J Clin Pathol

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IntroductionAs one of the lesser problems of physiology, the nature of blood coagulation has received more than its share of investigation. There is now an insurmountable mass of literature dealing with its various aspects, contributed over the greater part of a century by some of the foremost experimentalists of their time, and embodying theories, even whole schools-of thought, that have produced little but acrimony and confusion. The reasons for this activity are not at once apparent, though no doubt there is something provocative to the curious mind in the spontaneous conversion of fluid blood to solid clot. More attractive, perhaps, is the ease with which experiments in blood coagulation can be devised and carried out. The requirements for such work in technique, apparatus, and even in time are seemingly not exacting. The real or imaginary components of a theoretical mechanism can be separated to the investigator's satisfaction with little difficulty and allowed to interact in endless permutations and combinations. Each experiment suggests another; always the intangible solution seems just within reach and the experimenter is led deeper and deeper into his own, often unjustified, interpretations of his findings. Thus it is that elaborate theories have grown up which, aided by the confusion of rival terminologies, have so obscured-and entangled basic facts that these are now scarcely recognizable.Within the last decade this hitherto rather academic problem has taken on a more practical aspect; the discovery of vitamin K and the use of anticoagulants to reduce the danger of post-operative thrombosis, both advances of fundamental importance, have demanded the reliable quantitative assay of coagulation factors. This development has necessarily clarified

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“…According to Knisely et al (4), anticoagulants may reduce blood sludging, which would facilitate blood flow. Similarly, platelet adhesions to vessel walls, especially at narrowed areas, would be reduced to a minimum, according to the findings of Spooner and Meyer (5). That such episodes did occur, due possibly to platelet or thrombotic emboli, is suggested by his “attacks” of confusion and falling.…”

Section: Case Reportsmentioning

confidence: 65%

Anticoagulant Therapy as a Potentially Effective Method for the Prevention of Presenile Dementia: Two Case Reports

Walsh

1968

J American Geriatrics Society

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The hypothesis is proposed that presenile dementia results from arterial insufficiency of the brain consequent to a thrombotic process in the arteries supplying the brain. In accord with this hypothesis is the observation that in 9 patients, long‐term anticoagulant therapy appeared to prevent the expected progression of the dementia. Two illustrative case histories are given in detail. It is suggested that further therapeutic trials are warranted. It is also suggested that a thorough investigation of both the intracranial and extracranial arterial blood supply to the brain in patients with presenile dementia might yield useful information as to the etiology.

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The Effect of Dicumarol (3,3'-Methylenebis [4-Hydroxycoumarin]) on Platelet Adhesiveness

Cited by 35 publications

References 0 publications

Dicumarol Therapy

Dicumarol Therapy

Normal and Abnormal Blood Coagulation: A Review

Anticoagulant Therapy as a Potentially Effective Method for the Prevention of Presenile Dementia: Two Case Reports

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