The Effect of Diclofenac Sodium on Renal Function

Abstract

The effects of diclofenac sodium on the kidneys were studied during 4 1/2 hours in eight patients with normal renal function. Urinary output decreased within 10 min after the injection, and maximally by 80%. The renal plasma flow and the glomerular filtration rate initially diminished significantly, by 35%, but began to increase after only 2 hours. The dominant and persistent effect was reduction of free water clearance, with maximum fall from 5.9 to 0.08 ml/min after 2 1/2 hours. The long-lasting increased tubular reabsorption of water probably is important for the lowered intrapelvic pressure that is associated with good analgetic effect of diclofenac in ureteral colic.

Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis

“…However, it is striking that the combination of L-NAME and diclofenac produced a marked inhibitory effect on the escape phenomenon, which was also accompanied by significant increase in kidney aquaporin-2 expression. It has been reported that diclofenac causes a decrease in glomerular filtration rate (GFR) (17,30), and we cannot deny the possibility that the decrease in urine flow may be caused by the decrease in GFR. However, aquaporin-2 expression was increased by diclofenac when it was administered with L-NAME.…”

Loxoprofen sodium treatment for elderly men with refractory nocturia: Effect on night‐time urine production

“…Kinn et al . reported that diclofenac sodium, an NSAID, reduced the renal plasma rate and glomerular filtration rate in normal functioning kidneys 8 . The most predominant effect of NSAIDs in the kidney was noticed on tubular resorption of sodium and water.…”

“…NSAIDs are widely used as analgesic drugs in clinical practice, and the inhibition of prostaglandin synthesis via inhibition of cyclooxygenase enzyme is the principle action mechanism of NSAIDs. Prostaglandins have the responsibility for maintaining homeostasis in various organs of the human body, and it is considered that they also play an important role in the pathogenesis of lower urinary tract dysfunctions; 7–10 therefore, NSAIDs are expected to be useful for patients with lower urinary tract symptoms and an overactive bladder.…”

Diclofenac Treatment Prolongs Renal Transit Time in Acute Ureteral Obstruction: A Renographic Study

“…The resultant reduction of renal blood flow and glomerular filtration rate (GFR) on the obstructed side leads to decrease of urinary output and of the painful hypertension in the renal pelvis and ureter [2]. Long–lasting increase of tubular water and sodium reabsorption also occurs, and presumably is a dominant factor in the decreased diuresis in response to diclofenac [3]. …”