The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle

Sivrikaya, Abdullah; ÇELİK>, Ömer; N, Sivrikaya; Özgür, Güner Kemal

doi:10.1023/b:urol.0000025618.68752.5b

Cited by 21 publications

(11 citation statements)

References 16 publications

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“…Lennon et al [6] showed an abrupt cessation of all spontaneous activity after the application of diclofenac at 10 −5 m to canine proximal ureter. Sivrikaya et al [7] reported a maximum mean ( sd ) reduction in tension of 43 (9)% after applying 10 −5 m diclofenac to proximal ureter pre‐contracted with 40 m m potassium chloride. However, maximum ureteric relaxation took 20 min after applying diclofenac.…”

Section: Discussionmentioning

confidence: 99%

A comparative in vitro study to determine the beneficial effect of calcium‐channel and α₁‐adrenoceptor antagonism on human ureteric activity

2006

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muscle tone in vitro . The ureter was obtained at open nephrectomy or cystectomy. Potassium-enriched Krebs' solution was used to evoke maximal muscle tone, followed by adding each drug in increasing concentrations to determine the percentage reduction in tone. The drugs used to represent each group were nifedipine, 5-methylurapidil (5-MU) and diclofenac. In all, 201 ureteric strips were obtained from 39 patients. RESULTSAt all drug concentrations, the in vitro relaxant effect of nifedipine and 5-MU was greater than that of diclofenac. At 10 − 5 M the median reduction in proximal and distal ureteric tone to diclofenac, nifedipine and 5-MU were 18%, 5% and 47%, vs 57%, 33% and 65%, respectively. CONCLUSIONNifedipine and 5-MU produced greater ureteric relaxation in vitro than diclofenac; they predominantly relax distal ureter. This suggests that a reduction in ureteric muscle tone, as opposed to complete ablation of activity, might be the promoting factor for stone passage.

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Section: Discussionmentioning

confidence: 99%

A comparative in vitro study to determine the beneficial effect of calcium‐channel and α₁‐adrenoceptor antagonism on human ureteric activity

2006

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“…Similarly to our preliminary investigation (data not shown), during which many different organ bath conditions failed to induce autonomic contractility on human ureteral tissue, Sivrikaya et al [13] tested many contractile agents (BaCl 2 , PGF 2α and KCl) to obtain tonic contractions, but unstable contractions were evident in the majority of cases. Accordingly, changes in KCl-induced contraction were used to calculate the effect of diclofenac sodium and papaverine on isolated human ureteral smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

In vitro Evaluation of Ureteral Contractility: A Comparative Assessment of Human, Porcine and Sheep Ureteral Response to Vardenafil

Kyriazis¹,

Kallidonis²,

Georgiopoulos³

et al. 2014

Urol Int

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Objectives: Basic science studies of ureteral physiology and pathophysiology are commonly performed on animal ureters due to several limitations associated with human ureteral sampling. In this work we question whether animal ureters are good replicas of human ureteral behavior for pharmacological studies. Materials and Methods: Ureteral rings from human, porcine and ovine ureters underwent the same organ bath protocol. After stimulation with KCl, ureters were subjected to different doses of vardenafil. Basic contractility and ureteral response to vardenafil were analyzed. Results: A different pattern of basic contractility was evidenced between species. Vardenafil administration induced a dose-dependent reduction in KCl-induced amplitude increase in human ureters and a dose-dependent reduction in autonomic contractile rhythm of porcine and ovine ureters. Although animal ureters could predict the relaxant response of human samples to vardenafil, its effect would have been overestimated using only animal models. Conclusions: Human ureteral investigations cannot entirely be replaced by existing animal models since results of the latter will vary significantly according to the tested pharmaceutical agent.

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“…Their results of that in benign prostate hyperplasia there is an increase in the stromal components (Chagas et al, 2002). The effect of DS on the urinary tract tissue was found to be more relaxant on ureteral smooth muscle (Sivrikaya et al, 2004). At the present time, DS is also used widely in the women of child-bearing age for the treatment of common gynecological problems.…”

Section: Introductionmentioning

confidence: 94%

The stereological ratio of stromal/parenchymal components in postnatal prostate tissue of rats prenatally treated with diclofenac sodium

Kara

Ragbetli²,

Koyun³

et al. 2013

jecm

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Article HistorySince diclofenac sodium extends the pregnancy and affects the fetus, our study aimed to stereologically investigate the components of the rat prostate with prenatally treated with diclofenac sodium. The rats were left overnight to mate. Pregnant animals were kept in a room tempreture with normal light and dark cycles and fed with normal diet. After injections to sham and treated groups for 15 days, 18 male offsprings were housed in three groups (6 placebo; 6 control; 6 treated). The 20 weeks-old animals were perfused and the prostates removed and embedded in paraffin. Tissue sections at 5µm thickness were taken at regular intervals and stained with Hematoxylin-eosin and Masson trichrome. Cavalieri principle was used for volume fractions analysis. Stereological examination revealed 55% acinar epitelium and 45% connective tissue in both control and placebo groups, as well as 60% acinar epitelium and 40% connective tissue in the treated group. Prenatally applied diclofenac sodium did not cause a statistically significant change in the prostate stroma-parenchymal ratio in 20-week old rats compared to the control animals (p>0.05).

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The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle

Abstract: Mean relaxation obtained by diclofenac sodium and papaverine were respectively 43.19% and 28.96%. Our study showed that diclofenac sodium may be more potent than papaverine in the treatment of renal colic.

Cited by 21 publications

References 16 publications

A comparative in vitro study to determine the beneficial effect of calcium‐channel and α₁‐adrenoceptor antagonism on human ureteric activity

A comparative in vitro study to determine the beneficial effect of calcium‐channel and α₁‐adrenoceptor antagonism on human ureteric activity

In vitro Evaluation of Ureteral Contractility: A Comparative Assessment of Human, Porcine and Sheep Ureteral Response to Vardenafil

The stereological ratio of stromal/parenchymal components in postnatal prostate tissue of rats prenatally treated with diclofenac sodium

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The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle

Abstract: Mean relaxation obtained by diclofenac sodium and papaverine were respectively 43.19% and 28.96%. Our study showed that diclofenac sodium may be more potent than papaverine in the treatment of renal colic.

Cited by 21 publications

References 16 publications

A comparative in vitro study to determine the beneficial effect of calcium‐channel and α1‐adrenoceptor antagonism on human ureteric activity

A comparative in vitro study to determine the beneficial effect of calcium‐channel and α1‐adrenoceptor antagonism on human ureteric activity

In vitro Evaluation of Ureteral Contractility: A Comparative Assessment of Human, Porcine and Sheep Ureteral Response to Vardenafil

The stereological ratio of stromal/parenchymal components in postnatal prostate tissue of rats prenatally treated with diclofenac sodium

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A comparative in vitro study to determine the beneficial effect of calcium‐channel and α₁‐adrenoceptor antagonism on human ureteric activity

A comparative in vitro study to determine the beneficial effect of calcium‐channel and α₁‐adrenoceptor antagonism on human ureteric activity