The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Abstract

Background Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence. Methods All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis. Results A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48–2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21–2.01), and it was 1.85 (95% CI 1.53–2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34–1.97). Conclusions Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

Association between metabolic syndrome and endometrial cancer risk: a systematic review and meta-analysis of observational studies

“…Another metabolic abnormality, diabetes, has also been found to be associated with EC risk, independent of obesity [11,12]. Two meta-analyses [34,35] quantitatively summarized the results of published observational studies reporting a greater risk of EC in subjects with diabetes compared with those without diabetes. In addition, the results of subgroup analysis according to the type of diabetes supported a positive association between type 1 and type 2 diabetes and EC [34].…”

Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study

“…Type 2 diabetes mellitus (T2DM) and cancer are two major global health issues, causing approximately 5.0 and 8.7 million deaths and 143.0 and 208.3 million disability-adjusted life-years in 2015 worldwide, respectively (1,2). Evidence from epidemiological studies indicates that T2DM is a risk factor for overall cancer (3) and several site-specific cancers, such as colorectal (4,5), liver (6), kidney (7,8), uterine (9), and breast cancer (10). A bidirectional relationship has been suggested for T2DM and pancreatic cancer (11)(12)(13)(14)(15), whereas an inverse association has been observed between T2DM and risk of prostate cancer (16,17).…”

Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway

“…EC is one of the most common cancers in women. In addition, the incidence and mortality rates of EC are expected to rise both in developed and developing countries with the increasing aging population and prevalence of obesity (32). Treatment for metastatic EC is ineffective and metastasis is the major reason for relapse and death, since there is no effective therapy for this condition (33).…”