The effect of diabetes mellitus on the lymphatic transport of intestinal sterols

Feingold, Kenneth R.; Zsigmond, G.; Hughes‐Fulford, Millie; Lear, Steven R.; Moser, Arthur H.

doi:10.1016/0026-0495(85)90154-4

Cited by 20 publications

(16 citation statements)

References 17 publications

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“…In concert with the hypothesis that exaggerated intestinal sterol synthesis leads to hypercholesterolemia, we found a modest elevation in plasma cholesterol in the Vil-Insig ؊ mice. One straightforward model would hold that increased enterocyte sterol synthesis directly increases secretion of chylomicron cholesterol; in support of this hypothesis, a previous report of thoracic lymph duct cannulation of diabetic rats showed increased secretion of chylomicron cholesterol in association with increased intestinal sterol synthesis (42). In the current studies, we saw no evidence for increased accumulation of cholesterol-rich, chylomicronsize particles in the Vil-Insig ؊ mice at steady state.…”

Section: Discussionsupporting

confidence: 53%

Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine

McFarlane

Liang

Engelking

2014

Journal of Biological Chemistry

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Section: Discussionsupporting

confidence: 53%

Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine

McFarlane

Liang

Engelking

2014

Journal of Biological Chemistry

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“…A two-to threefold increase in lymph flow in diabetic animals was observed throughout the observation period (up to 60 days). Other investigators have also reported a similar increase in the volume of the lymph drainage in streptozotocindiabetic rats [48] through increased transport of newly synthesized cholesterol from the intestine to the circulation. We demonstrated, additionally, that not only was the lymph flow from the intestine greater in diabetic rats but the transport of the radiotracer 99m Tc-dextran 500 from the footpad subcutaneous tissue toward the thoracic duct was also enhanced two-to threefold.…”

Section: Discussionmentioning

confidence: 77%

Lymphatic system changes in diabetes mellitus: role of insulin and hyperglycemia

Moriguchi

Sannomiya

Lara

et al. 2005

Diabetes Metab. Res. Rev.

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confidence: 97%

“…Studies from this laboratory using thoracic duct-cannulated control and diabetic animals have demonstrated that the transport of newly synthesized cholesterol from the intestine into the circulation is increased 4-fold in insulinopenic diabetic rats (7). In both the controls and diabetics the vast majority (~80%) of the newly synthesized cholesterol is transported in the chylomicron lipoprotein fraction (7). Employing entirely different experimental methods Young et al (8) have also shown that cholesterol synthesized in the small intestine is transported into the circulation to a greater extent in diabetic animals than in controls.…”

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confidence: 98%

The Disappearance from the Circulation of Chylomicrons Obtained from Control and Diabetic Rats*

1987

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Previous studies have demonstrated that cholesterol synthesis is increased in the small intestine of diabetic animals and that there is an increased transport of this newly synthesized cholesterol from the small intestine into the circulation. Chylomicrons play an important role in the transport of cholesterol from the small intestine into the circulation, and the present study compared the rates of disappearance from the circulation and the fate of chylomicron cholesterol obtained from control and diabetic animals when administered to either intact control or diabetic rats. Thoracic duct lymph was collected from normal and diabetic rats after the administration of [14C]cholesterol and [3H]vitamin A1. The labeled chylomicrons were isolated by centrifugation and then administered to either control or diabetic rats. The major observation of this study is that chylomicron-associated sterols obtained from diabetic animals were cleared from the circulation in a normal manner. If one compares the rate of disappearance of either [3H]vitamin A1 or [14C] cholesterol-labeled normal chylomicrons administered to control animals with that of labeled diabetic chylomicrons administered to diabetic animals, the half-times in the circulation are almost identical (control: [3H]vitamin A1 t 1/2, 3.6 min; [14C]cholesterol t 1/2, 5.7 min; diabetic: [3H]vitamin A1 t 1/2, 3.5 min; [14C]cholesterol t 1/2, 4.4 min). In both experimental situations the rapid disappearance of [14C]cholesterol was associated with the appearance of [14C]cholesterol in the liver. Very little [14C]cholesterol was present in tissues other than liver, indicating that the rapid removal of labeled chylomicron remnants from the circulation was accounted for by hepatic uptake. These results demonstrate that in diabetic animals chylomicron-associated sterols are cleared from the circulation normally and that the bulk of intestinally derived cholesterol carried in the chylomicron lipoprotein fraction is rapidly delivered to the liver, where it could potentially influence lipoprotein metabolism.

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The effect of diabetes mellitus on the lymphatic transport of intestinal sterols

Cited by 20 publications

References 17 publications

Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine

Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine

Lymphatic system changes in diabetes mellitus: role of insulin and hyperglycemia

The Disappearance from the Circulation of Chylomicrons Obtained from Control and Diabetic Rats*

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