The effect of dexmedetomidine infusion on propofol requirement for maintenance of optimum depth of anaesthesia during elective spine surgery

Abstract

Background:Maintenance of adequate depth of anaesthesia in spine surgery is vital to prevent awareness, to reduce stress response and possible autonomic instability frequently associated with spine surgery. Dexmedetomidine, a α2-adrenoceptor agonist with analgesic and sedative adjuvant property has been found to reduce dose requirement of multiple anaesthetic agents both for induction and during the maintenance of anaesthesia.Aim:The aim of this study is to observe the effect of dexmedetomidine, on the requirement of propofol for induction and maintenance of adequate depth of anaesthesia during spine surgery.Methods:It was a prospective, randomised, double-blinded, parallel group, placebo controlled and open-lebel study in tertiary care hospital. A total of 70 patients aged 20-60 years, American Society of Anaesthesiologists GradeI and II, scheduled for elective spine surgery were randomly allocated into two groups. Each patient of Group D (n=35) received an initial loading dose of dexmedetomidine at 1 μg/kg over 10 min, started 15 min before induction of anaesthesia followed by an infusion at a rate of 0.2 μg/kg/h. Patients of Group P (n=35) received the same volume of 0.9% normal saline solution as placebo. Requirement of propofol at induction and during maintenance was calculated maintaining bispectral index between 40 and 60. P<0.05 was considered to be statistically significant.Results:Mean requirement of propofol was found to be lessened by 48.08% and 61.87% for induction and maintenance of anaesthesia respectively while using dexmedetomidine.Conclusion:Administration of dexmedetomidine significantly reduces the requirement of propofol while maintaining desired depth of anaesthesia without any significant complication.

Effects of Premedication with Dexmedetomidine on Perioperative Hemodynamics and Anesthetic Requirements during Elective General Abdominal Surgeries

“…The mean dose of propofol needed for induction was reduced significantly by 43.01% in the patients receiving dexmedetomidine. This finding was in consistent with the study done by Suvadeep Sen et al 19 . who studied the effect of dexmedetomidine infusion on propofol requirement for maintenance of optimum depth of anaesthesia during elective spine surgery and concluded that requirement of propofol at induction and during maintenance was lessened by 48.08% and 61.87% respectively and dose was calculated maintaining bispectral index between 40 and 60 (p<0.05).…”

Intranasal Dexmedetomidine in Termination of First Trimester Pregnancy of Suction Evacuation

“…Therefore we demonstrated that intranasal dexmedetomidine reduced the propofol requirement during termination of first trimester pregnancy of suction evacuation. Our result was also consistent with other previous studies that dexmedetomidine might reduce the anesthetic dosages [8,9,23]. Guan et al showed that the mean consumption of propofol for termination of first trimester pregnancy of suction evacuation was 3.56 ± 0.98 mg/kg for propofol and 2.11 ± 1.08 mg/kg for propofol combined with sulfentanil5.…”

Dexmedetomidine Decreases Propofol Dose Requirement for Induction of Anaesthesia: A Comparative Study Conducted on Patients Undergoing Laparoscopic Cholecystectomy

“…[15] A study done by Suvadeep Sen et al have shown a 48.08%dose reduction of propofol induction dose in patients who received dexmedetomidine before induction of anaesthesia. [16] Our results have shown a 50.6% reduction in propofol dose for induction after receiving dexmedetomidine infusion. In our study, it was found that mean induction dose of propofol was significantly lower in group A 67±13.67mg as compared to group B 126±14.73 mg that is statistically significant [p<0.05%].…”