The effect of dexamethasone on the uptake of p-boronophenylalanine in the rat brain and intracranial 9L gliosarcoma

Morris, G. M.; Micca, Peggy L.; Coderre, Jeffrey A.

doi:10.1016/j.apradiso.2004.05.007

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…[1][2][3] Many studies of various boron-containing compounds have focused on BNCT applications. [3][4][5][6][7] However, p-boronophenylalanine 4 ͑BPA͒ and mercaptoundecahydrododecaborate 6 ͑BSH͒ have been the only clinically used chemicals because of their safety, which has been verified for a long term, and their specific functions in tumor cells. BPA can be ingested by a tumor cell through the amino-acid transport system, 7 while BSH can selectively permeate a blood-brain barrier in a brain tumor cell.…”

Section: Boron Carbide Spherical Particles Encapsulated In Graphite Pmentioning

confidence: 99%

Boron carbide spherical particles encapsulated in graphite prepared by pulsed laser irradiation of boron in liquid medium

Ishikawa¹,

Shimizu²,

Sasaki³

et al. 2007

Applied Physics Letters

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Section: Boron Carbide Spherical Particles Encapsulated In Graphite Pmentioning

confidence: 99%

Boron carbide spherical particles encapsulated in graphite prepared by pulsed laser irradiation of boron in liquid medium

Ishikawa¹,

Shimizu²,

Sasaki³

et al. 2007

Applied Physics Letters

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“…At the end of the surgery in the first group (G1), 10 mL of a hypertonic glucose (10%) solution was left in the pelvic cavity. The second group (G2) was given 10 mL of a 1:1 combination of hypertonic glucose (10%) and dexamethasone 3 mg·kg –1 (Decadron, Aché, São Paulo, SP, Brazil) according to Morris et al 15 . The third group (G3), which were the controls, were given 10 mL of 0.9% saline solution.…”

Section: Methodsmentioning

confidence: 99%

Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

et al. 2021

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Purpose To evaluate the efficacy of hypertonic glucose (10%), alone or in combination with the corticoid dexamethasone, to prevent peritoneal adhesion following hysterectomy in rats. Methods Forty-two adult rats underwent hysterectomy with peritoneal lavage: G1 – glucose (10%); G2 – glucose (10%) and dexamethasone 3 mg·kg –1 ; and G3 – physiological saline (PS) 0.9%. Results In the macroscopic analysis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001), G3 compared to G1 and G2. There was no difference between groups after 28 days. In the microscopic analysis, the median vascular proliferation after 14 days was 2 for G1, 1 for G2, and 3 for G3 (p = 0.0037, G3 vs. G1 and G2). After 28 days, G1 showed a median vascular proliferation score of 2, G2 of 2.5, and G3 of 3 (p < 0.0001, G3 vs. G1 and G2). Regarding the inflammatory reaction after 14 days, G1 had a median score of 2, G2 of 1, and G3 of 3 (p = 0.7916). After 28 days, G1 had a median score of 0.5 (0–1.75), G2 of 1.5, and G3 of 2.5 (p < 0.0001, G3 vs. the others and G2 vs. G1). In the evaluation of fibrosis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001, G3 vs. G1and G2). After 28 days, G1 had a median fibrosis score of 1, G2: 2, and G3: 2.5 (p < 0.0001), G3 vs. the others andG2 vs. G1). Conclusions The use of hypertonic glucose (10%) solution seems to reduce macroscopic and microscopic pelvic adhesions.

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“…This feature is expected to be suitable for fabricating particles for biomedical use. In this study, we report B 4 material and dispersed in ethyl acetate (99.5%, Wako Pure Chemical Industries, Ltd.). The suspension of 6 ml including 0.24 mg B 4 C was irradiated with the third harmonic (355 nm) of Nd:YAG laser operated at 10 Hz with pulse width of 7 ns.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Many studies of various boron-containing compounds have focused on BNCT applications. [3][4][5][6][7] However, p-boronophyenylalanine (BPA) and mercaptoundecahydrododecaborate (BSH) have been the only clinically used due to their safety and specific function in tumor cells, whereas they contain a slight amount of B within their molecules. Because concentrated B in a tumor cell is required for highly effective therapy, 2 8 the enormous doses of BPA and BSH that are necessary impose a strain on the patient.…”

Section: Introductionmentioning

confidence: 99%

Submicron-Sized Boron Carbide Particles Encapsulated in Turbostratic Graphite Prepared by Laser Fragmentation in Liquid Medium

Ishikawa

Sasaki²,

Koshizaki³

2010

J. Nanosci. Nanotech.

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Submicron-sized B4C spherical particles were obtained by laser fragmentation of large B4C particles dispersed in ethyl acetate. The irradiated surface of large B4C raw particles was heated and melted by laser energy absorption. B4C droplets were then cooled down, and finally B4C spherical particles were obtained. Moreover, each B4C particle obtained was encapsulated in a graphitic layer that is useful for medical functionalization of particles. Thus, obtained B4C particles encapsulated in graphitic layer may have potential uses in boron neutron capture therapy.

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The effect of dexamethasone on the uptake of p-boronophenylalanine in the rat brain and intracranial 9L gliosarcoma

Cited by 7 publications

References 19 publications

Boron carbide spherical particles encapsulated in graphite prepared by pulsed laser irradiation of boron in liquid medium

Boron carbide spherical particles encapsulated in graphite prepared by pulsed laser irradiation of boron in liquid medium

Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

Submicron-Sized Boron Carbide Particles Encapsulated in Turbostratic Graphite Prepared by Laser Fragmentation in Liquid Medium

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