The Effect of Deworming School Children on Anemia Prevalence: A Systematic Review and Meta-Analysis

Girum, Tadele; Wasie, Abebaw

doi:10.2174/1874434601812010155

Cited by 32 publications

(28 citation statements)

References 16 publications

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“…This may be attributable to a reduction of helminth burden due to albendazole given to both arms. This result also supported by research conducted on the effect of deworming on anemia prevalence [27,28]. Furthermore, the daily supervision of a bread provider at the household level may have created awareness of sanitation and child-feeding practices, which in turn may have had a positive impact by decreasing the incidence of inflammation and improved dietary diversity.…”

Section: Plos Onementioning

confidence: 70%

Efficacy of processed amaranth-containing bread compared to maize bread on hemoglobin, anemia and iron deficiency anemia prevalence among two-to-five year-old anemic children in Southern Ethiopia: A cluster randomized controlled trial

et al. 2020

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Background Few studies have evaluated iron-rich plant-based foods, such as amaranth grain, to reduce anemia and iron deficiency anemia. Amaranth is rich in nutrients, but with high level of phytate. The objective of this trial was to evaluate the efficacy of home processed amaranth grain containing bread in the treatment of anemia, hemoglobin concentration and iron deficiency anemia among two-to-five year-old children in Southern Ethiopia. Method Children with anemia (hemoglobin concentration <110.0g/L) (N = 100) were identified by random sampling and enrolled in a 1:1 cluster randomized controlled trial for six months in 2017. The amaranth group (N = 50), received 150g bread containing 70% amaranth and 30% chickpea, the amaranth grain was processed at home (soaking, germinating, and fermenting) to decrease the phytate level. The maize group (N = 50), received 150g bread, containing processed maize (roasted and fermented) to give a similar color and structure with amaranth bread. Hemoglobin, ferritin, and CRP were measured at baseline and at the end of intervention. Hemoglobin and ferritin values were adjusted for altitude and infection, respectively. Generalized estimating equation and generalized linear model were used to analyze the data. Result In the last follow-up measure anemia prevalence was significantly lower in the amaranth group (32%) as compared with the maize group (56%) [adjusted risk ratios, aRR: 0.39 (95%

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Section: Plos Onementioning

confidence: 70%

Efficacy of processed amaranth-containing bread compared to maize bread on hemoglobin, anemia and iron deficiency anemia prevalence among two-to-five year-old anemic children in Southern Ethiopia: A cluster randomized controlled trial

et al. 2020

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“…We included nine Cochrane reviews ( 20 , 21 , 28 , 31 , 38 , 41 , 46 , 49 , 50 ) and 22 non-Cochrane SRs ( 22 – 27 , 29 , 30 , 32 – 37 , 39 , 40 , 42 – 45 , 47 , 48 ). Except for Cembranel et al ( 23 ), all other reviews are in the English language.…”

Section: Resultsmentioning

confidence: 99%

“…We found 11 reviews on iron supplementation ( 20 – 29 , 44 ). Six reviews were on fortification ( 28 , 30 , 33 , 35 , 39 , 57 ); five reviews on supplementation with fortification ( 41 – 45 ); two reviews on deworming ( 46 , 47 ); and one review each on H. pylori treatment ( 48 ), WASH intervention ( 49 ), and antimalarial intervention ( 50 ).…”

Section: Resultsmentioning

confidence: 99%

“…In children under 15 years of age, daily iron supplementation (MD = 8.38 g/L, 95%CI = 6.21–10.56; I 2 = 97%; 28 studies; 6,545 participants 3.3–15Y) ( 24 ) and iron with micronutrient supplementation (WMD = 0.69 g/L, 95%CI = 0.48–0.91; 18 studies; participants <15Y) showed better improvements in Hb than iron with micronutrient fortification (WMD = 0.61 g/L, 95%CI = 0.40–0.81; 15 studies; participants <15Y) ( 43 ). A school-based deworming program resulted in a decreased prevalence of anemia (WMD = 1.62, 95%CI = 1.01–2.25; I 2 = 0%; eight studies; 1,005,239 participants) ( 47 ).…”

Section: Resultsmentioning

confidence: 99%

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Interventions for Addressing Anemia Among Children and Adolescents: An Overview of Systematic Reviews

et al. 2021

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Context: Anemia is a public health problem that can lead to growth, cognitive, and motor impairments.Objective: To collate evidence on interventions for addressing childhood and adolescent anemia.Methods: In this overview of systematic reviews, we included Cochrane as well as non-Cochrane systematic reviews (SRs) irrespective of language and publication status. Two sets of review authors independently screened articles for eligibility and extracted data from relevant SRs. We present data in a tabular format and summarize results based on outcome reported, age of participants, and type of interventions. We also adopt a “measurement for change” approach to assess the utility of measurement for development of interventions in childhood and adolescent anemia.Results: Our search yielded 2,601 records of which 31 SRs were found eligible for inclusion. Results were favorable for fortification and supplementation with clear reduction in the risk of anemia and increase in hemoglobin levels across all age groups. Other interventions reported by the SRs were inconclusive and suggest further research.Conclusions: Current evidence suggests that fortification or supplementation with iron and micronutrients leads to better reduction in the risk of anemia and improvements in hemoglobin levels among children and adolescents. Results of this overview can help decision makers in informing selection of interventions to address childhood and adolescent anemia.Review Registration: PROSPERO CRD42016053687.

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“…Furthermore, as suggested by two of these studies [27,30], environmental factors such as the presence of high parasite burden, particularly from hookworms, as well as malaria, can also contribute to the development of anemia by producing intestinal iron losses and red cell hemolysis, respectively [46]. One systematic review also found that iron supplementation, in addition to deworming of schoolchildren, showed greater changes in hemoglobin and reduction of anemia than studies that just dewormed (n = 8 studies) [47]. An interesting case was seen in one of the included studies, Reddy et al (2014) [27] where anemia prevalence significantly decreased (−6.3%) among participants consuming DFS and who were dewormed at baseline, but did not significantly decrease (+1.5%) among those who only consumed DFS and were not dewormed at baseline.…”

Section: Discussionmentioning

confidence: 99%

Performance Factors Influencing Efficacy and Effectiveness of Iron Fortification Programs of Condiments for Improving Anemia Prevalence and Iron Status in Populations: A Systematic Review

2020

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Iron fortification of staple foods is a common practice around the world to reduce the prevalence of iron-deficiency anemia. More recently, fortified condiments, including salts, sauces, and powders, have been tested in various efficacy trials. However, there is limited information on how nutritional, environmental, and experimental factors affect their efficacy and effectiveness. The purpose of the present work was to systematically review performance factors affecting the efficacy of condiment fortification trials. Three databases were searched using a standardized keyword search and included based on four-point inclusion criteria. Studies were evaluated against a quality assessment tool and effect sizes were calculated. Studies were ranked as low or high performing, based on whether or not they significantly improved iron-deficiency outcomes (hemoglobin, anemia prevalence, and ferritin levels). Of the 955 retrieved studies, 23 were included—of which, nine performed poorly, eight performed highly, and six were classified as neither because they did not meet the criteria of assessing the three iron outcomes. Results showed that unsuccessful trials did not consider environmental factors such as parasitic infections, nutritional factors such as micronutrient deficiencies other than iron, consumer acceptability of the product or experimental factors such as monitoring and adherence to the trials. Two common performing factors identified among those studies performing highly vs. those that did not were the control of sensory changes and monitoring of consumption compliance (i.e., dose delivery). The present work can be used as decision-making support for nutrition policy makers when determining the appropriate implementation of condiment fortification programs.

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The Effect of Deworming School Children on Anemia Prevalence: A Systematic Review and Meta-Analysis

Cited by 32 publications

References 16 publications

Efficacy of processed amaranth-containing bread compared to maize bread on hemoglobin, anemia and iron deficiency anemia prevalence among two-to-five year-old anemic children in Southern Ethiopia: A cluster randomized controlled trial

Efficacy of processed amaranth-containing bread compared to maize bread on hemoglobin, anemia and iron deficiency anemia prevalence among two-to-five year-old anemic children in Southern Ethiopia: A cluster randomized controlled trial

Interventions for Addressing Anemia Among Children and Adolescents: An Overview of Systematic Reviews

Performance Factors Influencing Efficacy and Effectiveness of Iron Fortification Programs of Condiments for Improving Anemia Prevalence and Iron Status in Populations: A Systematic Review

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