The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury

Tsai, Shen‐Kou; Lin, Su-Man; Hung, Wei-Chih; Mok, Martin S.; Chih, Chun-Lien; Huang, Shiang‐Suo

doi:10.1016/j.lfs.2003.10.014

“…However, NO can have both beneficial and detrimental effects in ischemic brain, depending on the amount and source of NO production (Bhardwaj et al, 2003) (Figure 1). Inducible nitric oxide synthase (NOS) may be important for inhalational anesthetic preconditioning-induced neuroprotection in ischemic brain since it plays a role in the protection induced by ischemic preconditioning in brain (Huang, 2004). Two studies evaluating ischemic neuronal injury in rat would suggest that the neuroprotection from isoflurane preconditioning is indeed inducible NOS-dependent (Kapinya et al, 2002a;Zhao and Zuo, 2004).…”

Section: Nitric Oxidementioning

confidence: 99%

Inhalational Anesthetics as Neuroprotectants or Chemical Preconditioning Agents in Ischemic Brain

Kitano

¹

,

Kirsch

²

,

Hurn

³

et al. 2006

J Cereb Blood Flow Metab

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This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

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“…These anesthetics include isoflurane (Kawaguchi et al 2004;Xiong et al 2003), sevoflurane (Nakajima et al 1997;Payne et al 2005), desflurane (Erdem et al 2005;Tsai et al 2004), halothane (Haelewyn et al 2003), xenon , nitrous oxide (Abraini et al 2004;Haelewyn et al 2008), barbiturates (Warner et al 1996), propofol (Bayona et al 2004), ketamine (Proescholdt et al 2001), and the local anesthetic lidocaine (Siniscalchi et al 1998;Weber and Taylor 1994)..…”

Section: Supporting Discussionmentioning

confidence: 99%

Rodent Stroke Model Guidelines for Pre-clinical Stroke Trials (1st edition).

Liu¹,

Zhen²,

Meloni³

et al. 2009

J Exp Stroke Transl Med

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Translational stroke research is a challenging task that needs long term team work of the stroke research community. Highly reproducible stroke models with excellent outcome consistence are essential for obtaining useful data from preclinical stroke trials as well as for improving inter-lab comparability. However, our review of literature shows that the infarct variation coefficient of commonly performed stroke models ranges from 5% to 200%. An overall improvement of the commonly used stroke models will further improve the quality for experimental stroke research as well as inter-lab comparability. Many factors play a significant role in causing outcome variation; however, they have not yet been adequately addressed in the Stroke Therapy Academic Industry Roundtable (STAIR) recommendations and the Good Laboratory Practice (GLP). These critical factors include selection of anesthetics, maintenance of animal physiological environment, stroke outcome observation, and model specific factors that affect success rate and variation. The authors have reviewed these major factors that have been reported to influence stroke model outcome, herewith, provide the first edition of stroke model guidelines so to initiate active discussion on this topic. We hope to reach a general agreement among stroke researchers in the near future with its successive updated versions.

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“…These anesthetics include isoflurane (Kawaguchi et al 2004; Xiong et al 2003), sevoflurane (Nakajima et al 1997; Payne et al 2005), desflurane (Erdem et al 2005; Tsai et al 2004), halothane (Haelewyn et al 2003), xenon (David et al 2008), nitrous oxide (Abraini et al 2004; Haelewyn et al 2008), barbiturates (Warner et al 1996), propofol (Bayona et al 2004), ketamine (Proescholdt et al 2001), and the local anesthetic lidocaine (Siniscalchi et al 1998; Weber and Taylor 1994). .…”

Section: Anestheticsmentioning

confidence: 99%

Rodent Stroke Model Guidelines for Preclinical Stroke Trials (1st Edition)

Liu¹,

Zhen²,

Meloni³

et al. 2009

Journal of Experimental Stroke and Translational Medicine

View full text Add to dashboard Cite

Translational stroke research is a challenging task that needs long term team work of the stroke research community. Highly reproducible stroke models with excellent outcome consistence are essential for obtaining useful data from preclinical stroke trials as well as for improving inter-lab comparability. However, our review of literature shows that the infarct variation coefficient of commonly performed stroke models ranges from 5% to 200%. An overall improvement of the commonly used stroke models will further improve the quality for experimental stroke research as well as inter-lab comparability. Many factors play a significant role in causing outcome variation; however, they have not yet been adequately addressed in the Stroke Therapy Academic Industry Roundtable (STAIR) recommendations and the Good Laboratory Practice (GLP). These critical factors include selection of anesthetics, maintenance of animal physiological environment, stroke outcome observation, and model specific factors that affect success rate and variation. The authors have reviewed these major factors that have been reported to influence stroke model outcome, herewith, provide the first edition of stroke model guidelines so to initiate active discussion on this topic. We hope to reach a general agreement among stroke researchers in the near future with its successive updated versions.

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The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury

Cited by 29 publications

References 22 publications

Inhalational Anesthetics as Neuroprotectants or Chemical Preconditioning Agents in Ischemic Brain

Inhalational Anesthetics as Neuroprotectants or Chemical Preconditioning Agents in Ischemic Brain

Rodent Stroke Model Guidelines for Pre-clinical Stroke Trials (1st edition).

Rodent Stroke Model Guidelines for Preclinical Stroke Trials (1st Edition)

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