The Effect of Date Seed (Phoenix dactylifera) Extract on Paraoxonase and Arylesterase Activities in Hypercholesterolemic Rats

Takaeidi, Mohammad Reza; Jahangiri, Alireza; Khodayar, Mohammad Javad; Siahpoosh, Amir; Yaghooti, Hamid; Rezaei, Saeid; Salecheh, Maryam; Mansourzadeh, Zahra

doi:10.17795/jjnpp-10368

Cited by 48 publications

(37 citation statements)

References 25 publications

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“…However, El-Fouhil, Ahmed, and Darwish (2010) reported that diabetic rats fed on boiled aqueous date seed extract resulted in significant hypoglycaemia. In addition, Takaeidi et al (2014) reported that methanolic date seed extract was able to promote the activities of serum paraoxonase (PON1) enzyme, which is known to be protective against oxidative stress related to diabetic complications. These studies pointed to the possible role of date seeds polyphenol in diabetic control.…”

Section: Inhibition Of α-Glucosidasementioning

confidence: 99%

Antioxidant activities and inhibitory effects of free and bound polyphenols from date (Phoenix dactylifera L.) seeds on starch digestive enzymes

Sirisena

Ajlouni

2016

IJFS

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Date (Phoenix dactylifera L.) seeds have gained interest as a valuable by-product of the date fruit industry and have been identified as a rich source of functional and bioactive ingredients. In this study, date seeds from five varieties (Medjool, Deglet Nour, Barhee, Bou Sthammi and Dayrie) cultivated in Australia were analysed for their total phenolic and flavonoid contents, ferric reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC), and in-vitro inhibition against α-amylase and α-glucosidase. The date seed powders (DSP) were extracted with acetone-methanol-water (2:2:1, v:v:v) to obtain free polyphenols. The bound polyphenols were extracted from the residual solids with butanolHCl (97.5:2.5; v/v) treatment at 100°C. The greatest quantities of total phenols (4166±227 mg Gallic Acid Equivalents 100g −1 DSP), total flavonoids (52.1±9.6 mg Quercetin Equivalents 100g −1 DSP), FRAP (1589±47 µmol Iron (II) Equivalents g −1 DSP) and TEAC (45.2±1.4 µmol Trolox Equivalents g −1 DSP) were detected in seeds from Deglet Nour variety. Both free and bound polyphenol fractions showed significant (p<0.05) inhibition against rat intestinal α-glucosidase with little or no inhibition against pancreatic α-amylase. Bound polyphenols showed stronger α-glucosidase inhibition compared with free polyphenols. The IC50 for α-glucosidase were reported as mg GAE mL −1 ranged from 0.39±0.02 (Deglet Nour ) to 0.68±0.02 (Medjool ) for bound polyphenols, and from 0.907±0.08 (Medjool ) to 1.75±0.15 (Barhee-khalal ) for free polyphenols. Bound polyphenol fraction, with strong α-glucosidase inhibition and weak α-amylase inhibition, was suggested as a significant source of functional food ingredients with anti-hyperglycaemic properties.

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Section: Inhibition Of α-Glucosidasementioning

confidence: 99%

Antioxidant activities and inhibitory effects of free and bound polyphenols from date (Phoenix dactylifera L.) seeds on starch digestive enzymes

Sirisena

Ajlouni

2016

IJFS

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“…21 In addition, date seed extract supplementation increased serum paraoxonase catalytic activity in hypercholesterolemic rats. 22 The effects of pomegranate polyphenols and their metabolites, and date fruit or seeds on free radical scavenging activity, LDL oxidation, and cholesterol and triglyceride accumulation have not been studied in detail yet. Since the various phenolics and metabolites in pomegranates and dates differ in their structure and in their biological activity, the combination of pomegranate and date constituents could possibly provide added value over their unique antiatherosclerotic properties.…”

Section: Introductionmentioning

confidence: 99%

Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

et al. 2015

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Hydrolysable tannin polyphenols in pomegranate and phenolic acids in date fruit and seeds are potent antioxidants and anti-atherogenic agents, and thus, in the present study we investigated the possible benefits of combining them in vivo in atherosclerotic apolipoprotein E KO (E(0)) mice, compared with the individual fruit. In vitro studies revealed that the date seed extract contains more polyphenols than Amari or Hallawi date extracts, and possesses a most impressive free radical scavenging capacity. Similarly, pomegranate juice (PJ), punicalagin, punicalain, gallic acid, and urolithins A and B are very potent antioxidants. E(0) mice consumed 0.5 μmol gallic acid equivalents (GAE) per mouse per day of PJ, Hallawi extract, date seed extract, or a combination for 3 weeks. Consumption of the combination was the most potent treatment, as it decreased serum cholesterol and triglyceride levels, and increased serum paraoxonase 1 (PON1) activity. Consumption of the combination also significantly reduced mouse peritoneal macrophage (MPM) oxidative stress, MPM cholesterol content, and MPM LDL uptake. Finally, the lipid peroxide content in the aortas of the mice significantly decreased, and the PON lactonase activity of the aortas increased after treatment with the combination. We thus conclude that consumption of pomegranate, together with date fruit and date seeds, has the most beneficial anti-atherogenic effects on E(0) mice serum, macrophages, and aortas, probably due to their unique and varied structures.

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“…Other symptoms include the passing of gravel or small stones in the urine, nausea or vomiting, pain during urination and an urgent need to urinate (Rose BD., 2009). Some natural product such as date Palm seeds contain some chemical compound work as antioxidant and many other materials which help to prevent kidney and liver also it has some compound acting as anti free radical (Ahmed AF1, et al, 2015), (Takaeidi MR1, et al, 2014), (Ambigaipalan P1, and Shahidi F 2015). Some other studies indicate that date Palm seeds contain an active compounds could prevent DNA and work as antiviral activity (Abdelaziz DH, and Ali SA, 2014), (Jassim SA, and Naji MA, 2010).…”

Section: Int J Adv Res 5(4) 623-627mentioning

confidence: 99%

Estimation the Ability of Water, Extracts of Barley Seeds and Date Palm Seeds, on Kidney Stone Decomposition in Vitro.

Ijar¹,

Jabir.²

2017

IJAR

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The Effect of Date Seed (Phoenix dactylifera) Extract on Paraoxonase and Arylesterase Activities in Hypercholesterolemic Rats

Cited by 48 publications

References 25 publications

Antioxidant activities and inhibitory effects of free and bound polyphenols from date (Phoenix dactylifera L.) seeds on starch digestive enzymes

Antioxidant activities and inhibitory effects of free and bound polyphenols from date (Phoenix dactylifera L.) seeds on starch digestive enzymes

Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

Estimation the Ability of Water, Extracts of Barley Seeds and Date Palm Seeds, on Kidney Stone Decomposition in Vitro.

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