The effect of DASH diet on glycemic response, meta-inflammation and serum LPS in obese patients with NAFLD: a double-blind controlled randomized clinical trial

Rooholahzadegan, Farnaz; Arefhosseini, Sara; Tutunchi, Helda; Badali, Taghi; Khoshbaten, Manuchehr; Ebrahimi-Mameghani, Mehrangiz

doi:10.1186/s12986-023-00733-4

Cited by 8 publications

(5 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(2) Studies on the treatment of NAFLD. Many pieces of evidence showed that calorie restriction ( 18 , 19 ), fat restriction ( 20 , 21 ), carbohydrate reduction ( 22 , 23 ), and appropriate vitamin supplementation ( 24 , 25 ) in diet therapy, aerobic exercise ( 26 , 27 ) resistance exercise ( 28 , 29 ) and high-intensity interval training ( 30 ) in exercise therapy had good therapeutic effects. Moreover, clinical experiments have proved that combining diet and exercise may achieve better therapeutic efficacy than a single one ( 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Shi,

Xiong,

Song

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

IntroductionThe primary treatment for non-alcoholic fatty liver disease (NAFLD) is modifying lifestyle through dietary or exercise interventions. In recent decades, it has received increasing attention. However, the lack of bibliometric analysis has posed a challenge for researchers seeking to understand the overall trends in this field.MethodsAs of February 3rd, 2024, 876 articles on treating NAFLD through diet or exercise therapy from 2013 to 2023 had been retrieved. Two software tools, VOSviewer and CiteSpace, were utilized to analyze the growth of publications, countries, institutions, authors, journals, citations, and keywords. Additionally, the keywords with strong citation burstiness were identified to determine the changes and future trends of research hotspots in this field.ResultsChina had the highest number of articles, followed by the United States and South Korea. Yonsei University and Nutrients were the institutions and journals with the most significant contributions. Professor Younossi Zobair M, from the United States, is the most prolific author in this field. Through analyzing the keywords, three research hotspots were identified: research on the pathogenesis of NAFLD, research on the treatment modalities of NAFLD, and research on the risk factors and diagnosis methods of NAFLD. In recent years, the research emphasis in this field has changed, suggesting that future research will focus on two frontier keywords: “oxidative stress” and “aerobic capacity.”ConclusionIn the past eleven years, the attention in this field was still rising, and the authors, journals, countries and so on had formed a considerable cooperative relationship. There were also many highly influential and productive researchers in this field. It is speculated that new research will continue around “aerobic exercise” and “oxidative stress” in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Shi,

Xiong,

Song

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…The implementation of a Dash diet is also beneficial for improving inflammatory markers. Rooholahzadegan et al (2023) showed a decrease in body weight, BMI, serum triglycerides, very low-density lipoprotein cholesterol (VLDL-C), MCP-1, and improvements in total antioxidant capacity (TAC) and glutathione (GSH).…”

Section: Effect Of Diet Modification In Inflammation and Oxidative St...mentioning

confidence: 99%

“…Dash diets also contain high levels of Ca and Mg. Calcium and magnesium are inversely related to obesity because of their role in increasing lipolysis, thus playing an important role in weight management. Calcium and magnesium are also known to be protective agents against DNA damage and antioxidant enzymes because they influence oxidative stress levels by increasing TAC and GSH as free radical scavengers (Rooholahzadegan et al, 2023). The mechanism of the benefits of the MedDiet and dash diet in reducing inflammation and oxidative stress is presented in Figure 1.…”

Section: Effect Of Diet Modification In Inflammation and Oxidative St...mentioning

confidence: 99%

Literature Review: The effect of modification diet and antioxidant on inflammatory and oxidative stress concentration in obesity

Mardhotillah,

Afifah,

Pramono

2024

Aceh. Nutri. J.

View full text Add to dashboard Cite

Obesity is also associated with increased inflammation and oxidative stress. Mediterranean and dash diets, as well as antioxidants, can reduce inflammation and oxidative stress levels in obesity. This study aimed to determine the effects of dietary modifications and antioxidants on inflammatory and oxidative stress levels in obesity. This study was carried out using the literature review method using PubMed, Science Direct, and Google Scholar databases with the keywords Mediterranean Diet, DASH Diet, Antioxidant, Obesity, Inflammation, and Oxidative Stress. The inclusion criteria in this literature are articles published in the last 5 years (2018-2023) using RCT, in English, subjects >18 years old with obesity, interventions providing Mediterranean and dash diet, antioxidants derived from natural ingredients, and articles that can be accessed online. Articles were selected individually through a double process, considering the three main research quality criteria. This study showed that a modified diet and antioxidants can reduce inflammatory biomarkers and oxidative stress in obesity by suppressing NF-κB signaling and protecting against DNA damage. In conclusion, a modified diet and antioxidants can reduce inflammatory and oxidative stress in obesity.

show abstract

“…Therefore, LPS binds to LPS-binding proteins and then binds to TLR-4, triggering insulin resistance, followed by an immune response and greater propensity for inflammation; that is, LPS increases the levels of gut-derived TLR4 since this receptor is activated in hepatic Kupffer cells and stellate cells. Further pro-inflammatory and pro-fibrotic pathways are stimulated through several cytokines, including IL1, IL6, and TNF [77,[131][132][133][134]. In MAFLD, TLR-4 signaling initiates local inflammatory changes and develops hepatic steatosis.…”

Section: Brain-gut-liver Axismentioning

confidence: 99%

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

De Cól,

de Lima,

Pompeu

et al. 2024

IJMS

View full text Add to dashboard Cite

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and fatty liver dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, and metabolic syndrome are frequently present; these conditions are related to liver lipogenesis and systemic inflammation. This study aimed to review the connection between the brain–gut–liver axis and MAFLD. The inflammatory process, cellular alterations in hepatocytes and stellate cells, hypercaloric diet, and sedentarism aggravate the prognosis of patients with MAFLD. Thus, to understand the modulation of the physiopathology of MAFLD, it is necessary to include the organokines involved in this process (adipokines, myokines, osteokines, and hepatokines) and their clinical relevance to project future perspectives of this condition and bring to light new possibilities in therapeutic approaches. Adipokines are responsible for the activation of distinct cellular signaling in different tissues, such as insulin and pro-inflammatory cytokines, which is important for balancing substances to avoid MAFLD and its progression. Myokines improve the quantity and quality of adipose tissues, contributing to avoiding the development of MAFLD. Finally, hepatokines are decisive in improving or not improving the progression of this disease through the regulation of pro-inflammatory and anti-inflammatory organokines.

show abstract

The effect of DASH diet on glycemic response, meta-inflammation and serum LPS in obese patients with NAFLD: a double-blind controlled randomized clinical trial

Cited by 8 publications

References 72 publications

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Literature Review: The effect of modification diet and antioxidant on inflammatory and oxidative stress concentration in obesity

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

Contact Info

Product

Resources

About