The effect of D-serine administration on cognition and mood in older adults

Avellar, Marcos; Scoriels, Linda; Madeira, Caroline; Vargas-Lopes, Charles; Marques, Patricia; Dantas, Camila; Manhães, Alex C.; Leite, Homero; Panizzutti, Rogério

doi:10.18632/oncotarget.7691

Cited by 35 publications

(17 citation statements)

References 34 publications

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“…Chapman et al [48] pointed out that threonine is a crucial amino acid which is essential in the gut mucins production and plays a vital role in the formation of tooth enamel, elastin and collagen in mammals. In addition, in healthy adults, the serine has been found to improve the executive function and memory [49]. Increased serine was also observed by Zhong et al [50].…”

Section: Discussionmentioning

confidence: 86%

Effects of Supplementation of Branches and Leaves Trimmed from Tea Plant on Growth Performance, Rumen Fermentation and Meat Composition of Nanjiang Yellow Goats

Shah

Cai

Zou

et al. 2019

Animals

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Simple SummaryThe effects of supplementation of branches and leaves trimmed from tea tree (BLTT) on growth performance, rumen fermentation characteristics and meat composition of fattening Nanjiang Yellow goats were studied. Supplementation of 4% BLTT increased final body weight of goats and also increased the activity of superoxide dismutase, while glutathione peroxidase and malondialdehyde followed the quadratic curve. Quadratic curves were also observed for villus height, crypt depth and the ratio of villus height to crypt depth in the jejunum. The quadratic effect was obtained for total essential amino acids, and individual amino acids threonine and leucine. Supplementation of 4% BLTT decreased the saturated fatty acid C16:0, and a quadratic effect was observed for polyunsaturated fatty acid C18:3 (n−3). From the present study, it is concluded that BLTT supplementation has a positive effect on body antioxidative status, gastrointestinal development, rumen fermentation characteristics and overall hence growth performance and meat composition in goats.AbstractThirty-two 6-month-old, healthy Nanjiang Yellow goats (34.6 ± 4.16 kg) were randomly divided into four treatments to evaluate the supplementary effects of branches and leaves trimmed from tea tree (BLTT) on growth performance, rumen fermentation characteristics, and meat composition in fattening goats. The control goats were fed a basal diet. Treatments 1, 2 and 3 were fed 2%, 4% and 6% of BLTT respectively. After a 60 d feeding trial, blood samples were collected for the analysis of the antioxidant profile and goats were slaughtered to obtain the rumen fluid and carcass samples for determination of rumen fermentation characteristics and meat composition perameters. Increased final body weight was observed in goats fed 4% BLTT compared with control. The activity of superoxide dismutase was increased in the 4% BLTT-treated group, while glutathione peroxidase and malondialdehyde followed the quadratic curve. Quadratic curves were also observed for villus height, crypt depth and the ratio of villus height to crypt depth in the jejunum. The quadratic effect was obtained for total essential amino acids, and individual amino acids threonine and leucine. The saturated fatty acid C16:0 was decreased with 4% of BLTT supplementation, and a quadratic effect was observed for polyunsaturated fatty acid C18:3 (n−3). To sum up, our findings revealed that BLTT supplementation has a positive effect on body antioxidative status, gastrointestinal development, rumen fermentation characteristics and overall growth performance and meat quality in goats.

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Section: Discussionmentioning

confidence: 86%

Effects of Supplementation of Branches and Leaves Trimmed from Tea Plant on Growth Performance, Rumen Fermentation and Meat Composition of Nanjiang Yellow Goats

Shah

Cai

Zou

et al. 2019

Animals

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“…In Brazil, the Continuous Visual Attention Test (CVAT) is commonly used for attentional assessments (Schmidt et al, 2008, 2016, 2017; Avellar et al, 2016; Simões et al, 2017; Simões et al, 2018a, b). The CVAT is a typical Go/No-go task approved for clinical use in Brazil that does not depend on IQ, has robust internal consistency and construct validity, as well as a high test–retest reliability (Schmidt and Manhães, 2004).…”

Section: Introductionmentioning

confidence: 99%

Decrease in Attentional Performance After Repeated Bouts of High Intensity Exercise in Association-Football Referees and Assistant Referees

Schmidt

Padilla

et al. 2019

Front. Psychol.

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Referees and assistant referees are submitted to high physical stress during matches. Pressure to make decisions in front of large crowds is another potential stressor. These two stressors can impair attention executive control, depending on physical fitness and individual vulnerability or resilience to situational pressure. Error percentage for referees and assistants may reach around 14% during a soccer match. Although previous studies have suggested that soccer referees and assistants should take cognitive assessments, they are only required by Fédération Internationale de Football Association (FIFA) to demonstrate knowledge of the rules and pass annually in a fitness test (FIFA-Test). This study aimed to assess attention performance in referees and assistants before and after the mandatory FIFA-Test. It is hypothesized that the high physical demands associated with the pressure to pass the FIFA-Test would interfere with attention performance. The sample included 33 referees and 20 assistants. The Continuous Visual Attention Test (CVAT) consisted of a 15-min Go/No-go task. Performance in the CVAT is based on four variables: omission and commission errors, reaction time, and variability of reaction time (VRT). Failure in the CVAT was defined by a performance below the 5th percentile of the age- and sex-matched normative data in at least one variable of the CVAT. Before the FIFA-Test all participants performed the CVAT. The second CVAT began 3–7 min directly following completion of the FIFA-test. Considering only the officials who passed both the FIFA-Test and the first CVAT (19 referees and 15 assistants), 44% (9 referees and 6 assistants) exhibited a performance decline in the second CVAT. A significant increase in VRT was found after the high intensity exercise. As increase in VRT is thought to reflect executive dysfunctions and lapses of attention, we concluded that physical fitness alone may not be enough to help officials cope with the physical and contextual stresses associated with the FIFA-Test. These data suggest that over 35% of soccer referees and their assistants who were considered physically able to referee matches may not be mentally prepared for the attentional demands of refereeing soccer matches.

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“…We developed two novelty detection tasks based on object features and object location respectively, using a sample trial and a test trial in order to be as close as possible to the computer-based tasks used in humans (Stark et al, 2013;. The second aim was to restore spatial PS performance in aged mice by means of Dserine, an endogenous co-agonist of NMDAR known to reverse age-dependent impairment of synaptic plasticity and cognitive performance in rodents and humans (Mothet et al, 2015;Avellar et al, 2016;Levin et al, 2015). Survival of new-born DG cells was subsequently quantified to examine whether D-serine modulates neurogenesis in aged mice (Sultan et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Age-related vulnerability of pattern separation in C57BL/6J mice

Cès

Burg

Herbeaux

et al. 2018

Neurobiology of Aging

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Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS performance. The present study investigated the effect of aging in C57BL/6J mice performing PS tasks based on either object features or object location. At the age of 18 months or more, performance was severely impaired in both tasks. Spatial PS performance declined gradually over adult lifespan from 3 to 21 months. Subchronic treatment with the cognitive enhancer D-serine fully rescued spatial PS performance in 18-month-old mice and induced a modest increase in the number of 4-week-old adult-born cells in the DG. Performance of mice in these PS tasks shows an age dependence, which appears to translate well to that found in humans. This model should help in deciphering physiological changes underlying PS deficits and in identifying future therapeutic targets.

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The effect of D-serine administration on cognition and mood in older adults

Cited by 35 publications

References 34 publications

Effects of Supplementation of Branches and Leaves Trimmed from Tea Plant on Growth Performance, Rumen Fermentation and Meat Composition of Nanjiang Yellow Goats

Effects of Supplementation of Branches and Leaves Trimmed from Tea Plant on Growth Performance, Rumen Fermentation and Meat Composition of Nanjiang Yellow Goats

Decrease in Attentional Performance After Repeated Bouts of High Intensity Exercise in Association-Football Referees and Assistant Referees

Age-related vulnerability of pattern separation in C57BL/6J mice

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