The effect of cystamine on gastric secretion in the rat

Parsons, Marie J.; Bunce, K.T.; Currington, A; Matheson, F.; Pipkin, Graham A.

doi:10.1007/bf01966696

Cited by 4 publications

(3 citation statements)

References 13 publications

(18 reference statements)

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“…to depletion of somatostatin [17][18][19] and liber ation of histamine [20][21][22]. Cysteamine-induced inhibition of acid-stimulated release of bicarbonate in the duodenum [23,24] or delayed gastric emptying [25][26][27] were also taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

An Acid-Independent Antiulcer Effect of M<sub>1</sub> Antimuscarinics in the Rat

Kromer¹,

Gönne²

1988

Pharmacology

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In the rat, the antiulcer potencies of the M₁antimuscarinics telenzepine and pirenzepine, the H₂ receptor blocker cimetidine, and the H⁺/K⁺-ATPase inhibitor omeprazole were compared with their antisecretory potencies. On a molar basis and with regard to inhibition of cysteamine-induced acid secretion, telenzepine ranked first, followed by omeprazole, cimetidine, and pirenzepine; cysteamine-induced duodenal ulcers were best inhibited by telenzepine, with pirenzepine, omeprazole and cimetidine ranking 2nd, 3rd and 4th. Up to the highest dose tested, cimetidine and omeprazole caused inhibition by 26 and 37%, respectively. While, with the antimuscarinics, lesion inhibition runs parallel with inhibition of acid secretion, the H₂ receptor blocker and the H⁺/K⁺-ATPase inhibitor markedly impair acid secretion, but do not or merely negligibly inhibit cysteamine-induced formation of duodenal ulcers. This suggests that in this animal model the antiulcer effect cannot be attributed exclusively to the antisecretory action.

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Section: Discussionmentioning

confidence: 99%

An Acid-Independent Antiulcer Effect of M<sub>1</sub> Antimuscarinics in the Rat

Kromer¹,

Gönne²

1988

Pharmacology

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“…A modified Ghosh & Schild (1958) technique described by Parsons (1969) was used in animals in which hydrogen ion (HW) secretion was measured. A small hole was made in the forestomach of a pylorus-ligated rat and any food residue present was washed out.…”

Section: Introductionmentioning

confidence: 99%

“…The stomach was perfused with warm 5% w/v glucose at 3 ml min-, the effluent perfusate passing over a pH electrode. Changes in pH were converted by an antilog unit (Parsons, 1969) …”

Section: Introductionmentioning

confidence: 99%