The effect of CYP3A4 genetic variants on the susceptibility to chronic obstructive pulmonary disease in the Hainan Han population

Abstract

Purpose Genetic polymorphisms act crucial role in chronic obstructive pulmonary disease (COPD) progression. This study was designed to investigate the correlation between CYP3A4 variants and COPD risk. Methods We carried out a case-control study of 821 individuals (313 patients and 508 healthy subjects) to identify the correlation of CYP3A4 SNPs with COPD risk in the Hainan Han population. The association was assessed by Odds ratios (OR) and 95% confidence intervals (CI). Results Our study showed that rs4646437 polymorphism was related to an increased susceptibility to COPD (OR = 1.45, 95% CI = 1.10-1.90, p = 0.008). Stratified analyses indicated that the rs4646437 polymorphism was significantly associated with an increased risk of COPD in males (OR = 1.95, 95% CI = 1.19-3.20, p = 0.008). However, rs4646440 played a protective role in females (OR = 0.54, 95% CI = 0.31-0.93, p = 0.024). The rs4646437 SNP was identified significantly improve the risk of COPD in smoking subjects (OR = 1.67, 95% CI = 1.12-2.48, p = 0.011). While rs4646440 had a significantly lower susceptibility to COPD with non-smoking individuals (OR = 0.64, 95% CI = 0.45-0.90, p = 0.010). Haplotype analysis revealed that A rs4646440 T rs35564277 and G rs4646440 T rs35564277 haplotypes of CYP3A4 were found to reduce the risk of COPD in non-smoking (OR = 0.61, 95% CI = 0.49-0.94, p = 0.024). Conclusion Our results would give some new understanding of the association between CYP3A4 gene and COPD in the Hainan Han population. P, Edwards RJ, Boobis AR et al: Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers. International journal of cancer 2000, 86(5):610-616. 28. Roberts-Thomson SJ, McManus ME, Tukey RH, Gonzalez FF, Holder GM: The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen. Biochemical and biophysical

An Analysis of the Effect of Noninvasive Positive Pressure Ventilation on Patients with Respiratory Failure Complicated by Diabetes Mellitus

“…With the advancement of medical technology, mechanical ventilation has made substantial progress in the treatment of severe respiratory failure and has shown significant therapeutic outcomes [5,6]. Noninvasive positive pressure ventilation obviates the need to establish an artificial airway.…”