The Effect of Cyclosporine A (Restasis) on Recovery of Visual Acuity Following LASIK

Abstract

<H4>PURPOSE</H4><p>To compare the recovery of uncorrected visual acuity (UCVA) following LASIK in patients treated with topical cyclosporine A 0.05% and patients treated with a standard postoperative regimen.</p> <H4>METHODS</H4><p>In this single-center, open-label, retrospective study, a standard refractive workup was performed in 45 patients (85 eyes) who underwent LASIK and did not have preexisting dry eye. In 36 eyes, a standard postoperative eye drop regimen was followed, and in 49 eyes, cyclosporine A 0.05% was added to the standard regimen for 12 weeks. Uncorrected visual acuity was measured 1 week and 1 and 3 months postoperatively.</p> <H4>RESULTS</H4><p>One week postoperatively, 22 (44.9%) eyes in the cyclosporine A group and 8 (22.2%) eyes in the standard treatment group had UCVA of 20/15. Cumulatively, 36 (73.5%) eyes in the cyclosporine A group and 24 (66.7%) eyes in the standard treatment group had UCVA of 20/20 or better. One month postoperatively, 37 (75.5%) in the cyclosporine A group and 23 (63.9%) eyes in the standard treatment group had UCVA of 20/20 or better. Three months postoperatively, 40 (81.6%) eyes in the cyclosporine A group and 25 (69.4%) eyes in the standard treatment group had UCVA of 20/20 or better. Mean UCVA in the cyclosporine A group showed statistically significant improvements compared with the standard treatment group.</p> <H4>CONCLUSIONS</H4><p>Cyclosporine A 0.05%, in the form of Restasis, may be an effective treatment for reducing the time needed for visual recovery after LASIK. Use of cyclosporine A was associated with overall better and faster recovery of UCVA. [<CITE>J Refract Surg.</CITE> 2008;24:473-476.]</p> <h4>ABOUT THE AUTHORS</h4> <p>From the Shiley Eye Center, University of California San Diego, La Jolla, Calif.</p> <p>Supported in part by an unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness Inc.</p> <p>The authors have no proprietary interest in the materials presented herein.</p> <p>Correspondence: David J. Schanzlin, MD, Shiley Eye Center, University of California San Diego, 9415 Campus Point Dr, #0946, La Jolla, CA 92093-0946. Tel: 858.822.1553; Fax: 858.822.1514; E-mail: <a href="mailto:dschanzlin@ucsd.edu">dschanzlin@ucsd.edu</a></p> <p>Received: August 17, 2006</p> <p>Accepted: April 24, 2007</p> <p><b>Posted online: October 15, 2007</b></p>

Cyclosporine 0.05% to improve visual outcomes after multifocal intraocular lens implantation

“…10,11 Laser in situ keratomileusis has a significant effect on the ocular surface and is associated with a high incidence of postoperative dry eye. 10 Studies 12,13 report that cyclosporine 0.05% treatment significantly improved the mean UDVA 3 months postoperatively in eyes with no preexisting dry eye and provided greater refractive predictability at 3 months and 6 months in eyes with preexisting dry eye.…”

Clinical Effectiveness of Topical Cyclosporine A 0.05% After Laser Epithelial Keratomileusis

“…Cyclosporine A 0.05% could improve LASIK outcomes on multiple levels by decreasing the incidence and severity of dry eye, improving the quality of vision and increasing the speed of visual recovery. 15 In addition, topical cyclosporine A 0.05% eye drops led to faster return of corneal sensitivity than control. 14 Because LASEK was presumed to have the similar mechanism of dry eye development with LASIK, topical cyclosporine A 0.05% is supposed to have a beneficial effect for dry eye after LASEK.…”

“…12 Topical cyclosporine A 0.05% increased tear production, improved corneal sensitivity, reduced the time needed for visual recovery, and provided greater refractive predictability after LASIK. 12,14,15 However, study on topical cyclosporine A 0.05% use after corneal surface ablation including LASEK has not been published yet. In this present study, we investigated the effect of topical cyclosporine A 0.05% on uncorrected visual acuity (UCVA), refractive error, corneal haze grade, symptom score, and parameters of the tear film and ocular surface after LASEK.…”

Nanoemulsions in Medicine

“…112 Restasis has also demonstrated dramatic diminution in the recovery time for post-operative LASIK patients to regain uncorrected visual acuity. 113 …”