The effect of Cyanidin-3-o-glucoside on UVA-induced damage in human dermal fibroblasts

Wu, Shengjun; Y, Hu; Li, Zhen; Bai, Weibin; Zhao, Jiayi; Huang, Cuiqin; Li, Qin; Fan, Chongzhu; Deng, Liehua; Lu, Daxiang

doi:10.1111/phpp.12374

Cited by 16 publications

(23 citation statements)

References 30 publications

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“…Apigenin is a naturally occurring flavonoid that has been shown to inhibit UV‐induced skin cancer by enhancing autophagy . In our previous studies, we showed that C3G, which is a flavonoid monomer, can counteract oxidative damage caused by 12 J/cm 2 UVA in primary HDFs . In this study, we further demonstrated that C3G can increase the expression of the autophagy‐associated proteins Atg5 and LC3‐Ⅱ in primary HDFs in a light‐damage model (Figure ).…”

Section: Discussionsupporting

confidence: 64%

“…Primary HDFs were obtained from normal human prepuce tissue and identified by immunofluorescence as previously described . All patients were recruited from the Department of Urology at the First Affiliated Hospital of Jinan University.…”

Section: Methodsmentioning

confidence: 99%

“…UVA can penetrate the skin to the dermis, and because fibroblasts are the primary component of the dermal cortex, we used primary human dermal fibroblasts (HDFs) in this investigation. In our previous study, we showed that UVA radiation can cause apoptosis in primary HDFs by increasing the formation of reactive oxygen species (ROS) . However, ROS and autophagy are closely related primarily because oxidative stress can induce autophagy and autophagy can reduce ROS …”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that milk thistle and olive extracts prevent sun‐induced skin damage, while ellagic acid and rosmarinic acid could prevent damage due to UVB in HaCaT cells . Our previous studies showed that cyanidin‐3‐o‐glucoside (C3G), which is a monomer of anthocyanin, can effectively and safely reduce UVA‐induced oxidative damage and apoptosis in primary HDFs . C3G is abundant in foods, such as black rice and black beans, and has several beneficial effects on health, including reducing age‐related oxidative stress and improving cognitive function.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous study, we showed that UVA radiation can cause apoptosis in primary HDFs by increasing the formation of reactive oxygen species (ROS). 7 However, ROS and autophagy are closely related primarily because oxidative stress can induce autophagy and autophagy can reduce ROS. 8 Autophagy is an important process involving the selective degradation of cellular components, allowing damaged proteins and organelles to be recovered and degraded for basic cellular maintenance while providing new raw materials to replace damaged or depleted cell components.…”

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confidence: 99%

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Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Bai

et al. 2019

Photoderm Photoimm Photomed

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Background/Purpose Ultraviolet (UV) A (315‐400 nm) is the UV light that most frequently reaches the Earth's surface and can penetrate the epidermis through to the dermis, causing various issues, including skin aging and skin cancer. The results of our previous studies have shown that the flavonoid monomer cyanidin‐3‐o‐glucoside (C3G) can effectively inhibit primary human dermal fibroblast (HDF) oxidative damage and apoptosis caused by UVA radiation. Many flavonoids can regulate the level of autophagy. However, whether C3G inhibits UVA‐induced oxidative damage to primary HDFs by regulating autophagy levels remains unclear. Methods and Results In this study, we used different doses (0‐12 J/cm2) of UVA to irradiate cells and showed that the expression levels of autophagy‐related gene 5 (Atg5) and microtubule‐associated protein 1 light chain 3 (LC3)‐II in primary HDFs first increased and then decreased. The expression of Atg5 and LC3‐II was significantly decreased under 12 J/cm2 (light‐damage model). C3G increased the levels of Atg5 and LC3‐II. Primary HDFs were pretreated with C3G, followed by treatment with the autophagy inhibitor 3‐methyladenine (3‐MA) after 12 J/cm2 UVA irradiation. The inhibitory effects of C3G on morphological changes, oxidative damage, and apoptosis in primary HDFs induced by UVA were significantly decreased. Conclusion C3G can inhibit UVA‐induced damage to primary HDFs by inducing autophagy. These results provide a theoretical basis for the application of natural compounds to resist light damage to the skin in the future.

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Section: Discussionsupporting

confidence: 64%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Bai

et al. 2019

Photoderm Photoimm Photomed

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Bioactivity and application of anthocyanins in skin protection and cosmetics: an extension as a functional pigment

Li,

Liu,

et al. 2023

Phytochem Rev

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Current developments in the nanomediated delivery of photoprotective phytochemicals

Kumar

Jose

2020

Environ Sci Pollut Res

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Natural products have been used to protect the skin from harmful UV radiation for decades. Due to the ecotoxicological implications of synthetic sunscreen exposure in aquatic ecosystems, there is a greater need to explore alternative sources of UV filters. Recent research has focused on discovering novel UV absorbing photoprotective molecules from nature. In response to the excessive damage caused by UVB rays, plants induce the production of high concentrations of phytoprotective secondary metabolites and anti-oxidative enzymes. Despite promising UV absorbing and photoprotective properties, plant secondary metabolites have been underutilized in topical delivery due to low solubility and high instability. Numerous phytochemicals have been effectively nanosized, incorporated in formulations, and studied for their sustained effects in photoprotection. The present review outlines recent developments in nanosizing and delivering photoprotective crude plant extract and phytochemicals from a phytochemical perspective. We searched for articles using keywords: "UV damage," "skin photoprotection," "photodamage," and "nano delivery" in varied combinations. We identified and reviewed literature from 43 original research articles exploring nanosized phytochemicals and crude plant extracts with photoprotective activity. Nanosized phytochemicals retained higher amounts of bioactive compounds in the skin and acted as depots for their sustained release. Novel approaches in nanosizing considerably improved the photostability, efficacy, and water resistance of plant secondary metabolites. We further discuss the need for broad-spectrum sunscreen products, potential challenges, and future growth in this area.

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The effect of Cyanidin-3-o-glucoside on UVA-induced damage in human dermal fibroblasts

Abstract: C3G reduced UVA-induced HDF oxidative damage and apoptosis, likely be related to the down-regulation of p-P38, up-regulation of ERK protein phosphorylation.

Cited by 16 publications

References 30 publications

Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Bioactivity and application of anthocyanins in skin protection and cosmetics: an extension as a functional pigment

Current developments in the nanomediated delivery of photoprotective phytochemicals

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