The Effect of CV12, ST25, ST36 Acupuncture in General Diet and High Fat Diet Rat

Abstract

Objectives : It was conducted to experimentally analyze the effects of acupuncture treatment at CV12, ST25, and ST36 on weight, FBCS, fat metabolism, microbiome, and metabolome changes in the general diet rat and the high-fat diet rat. Methods : It was classified into four groups: general diet & non-treatment group (ND), general diet & acupuncture treatment group (ND+AT), high-fat diet & non-treatment group (HFD), and high-fat diet & acupuncture treatment group (HFD-AT). After acupuncture treatment was performed on CV12, ST25, and ST36, changes in body weight, FBCS, fat metabolism, microbiome, and metabolome were analyzed. Results : Compared to the ND group, acupuncture treatment performed on CV12, ST25, and ST36 in the ND+AT group had no significant effect. Compared to the HFD group, CV12, ST25, and ST36 acupuncture in the HFD+AT group reduced weight, fat weight, inflammatory cytokine IL-6 expression, and lipid droplet accumulation in liver tissue. Acupuncture can promote fat metabolism and relieve inflammatory conditions. Differences in diversity between ND and HFD groups were clear in changes in microbiome, fecal metabolites, and serum metabolites. As a result of some microbiome and metabolites involved in fat decomposition, intestinal lipid absorption, and blood lipid concentration control, such as Intestinimonas, Ruminococcus 1, pyroglutamic acid, tryptophan, and inositol, it was observed that the acupuncture treatment effect was evident in the diseaseinduced imbalance. Conclusions : Acupuncture treatment performed on CV12, ST25, ST36 clearly observed various regulatory actions on obesity induced by high-fat diet, confirming that the action of acupuncture treatment mainly plays a role in controlling an unbalanced state.

A Case Report of an Elderly Patient with Psoriasis Treated with Jeongri-tang Gagam-bang: Focus on Digestive System Treatment

“…of an Elderly Patient with Psoriasis Treated with Jeongri-tang Gagam-bang: Focus on Digestive System Treatment http://dx.doi.org/10.13048/jkm.23055 179 metabolism in rats with high-fat diet-induced obesity20) . The weekly acupuncture treatments, along with the daily Jeongri-tang Gagam-bang (正 理湯加減方), may have helped improve the digestive function of our patients with psoriasis.Despite the fact that Jeongri-tang (正理湯) is composed of commonly used herbal medicines in Korea insurance system, there are no case reports of Jeongri-tang being used for skin diseases.Therefore, this study is significant in that it clinically confirmed the ability of Jeongri-tang Gagam-bang (正理湯加減方) to treat skin diseases by improve digestive system function.…”