The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial

Mirhafez, Seyed Reza; Azimi‐Nezhad, Mohsen; Dehabeh, Maryam; Hariri, Mitra; Naderan, Ronika Danesh; Movahedi, Ali; Abdalla, Mohammed; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1007/978-3-030-64872-5_3

Cited by 39 publications

(42 citation statements)

References 34 publications

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“…Compared with the placebo, supplementation resulted in significant decreases in serum levels of 3-methyl-2-oxovaleric acid, 3-hydroxyisobutyrate, kynurenine, succinate, citrate, α-ketoglutarate, methylamine, trimethylamine, hippurate, indoxyl sulfate, chenodeoxycholic acid, taurocholic acid, and lithocholic acid [114]. Furthermore, in another trial, where a total number of 80 patients were randomized to receive either 250 mg curcumin daily or the placebo for two months, the grade of hepatic steatosis, and serum aspartate aminotransferase levels were significantly reduced in the treatment group compared to the placebo [115].…”

Section: Digestive Diseasementioning

confidence: 96%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

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Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

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Section: Digestive Diseasementioning

confidence: 96%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

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“…However, no improvements in endothelial function or blood pressure were occurred with curcumin supplementation [ 63 ], contrary to the findings of Bank et al, which might be related to different genetic backgrounds or genders. Furthermore, in NAFLD patients, almost all metabolic parameters were improved [ 64 , 65 , 66 , 248 ]. In general, curcumin exerts great efficacy in improving obesity and regulating cardiovascular homeostasis.…”

Section: Non-flavonoidsmentioning

confidence: 99%

“…Existing clinical evidence shows that natural polyphenols significantly improve NAFLD. For example, curcumin and silybin both improved NAFLD in humans at different doses without significant gender bias [ 33 , 34 , 35 , 64 , 65 , 66 , 248 ]. However, the effects of resveratrol on patients with NAFLD are controversial [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Other Issues Of Natural Polyphenolsmentioning

confidence: 99%

“…Considering that both NAFLD and MetS are sex-binary disorders, this suggests that the effects of resveratrol are likely to be gender-biased. However, in clinical statistics, most of polyphenols were generally beneficial for both men and women [ 32 , 34 , 35 , 64 , 65 , 66 , 248 ]. Therefore, it is too early to conclude that resveratrol has a gender bias, because we cannot rule out the randomness issue of current clinical samples being too small ( n = 8 or 10), and large-scale human studies are needed to prove it.…”

Section: Other Issues Of Natural Polyphenolsmentioning

confidence: 99%

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Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications

Zhang

et al. 2021

IJMS

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Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance and inflammatory response. As enriched anti-inflammatory and antioxidant components in plants, natural polyphenols exhibit beneficial effects, including improving liver fat accumulation and dyslipidemia, reducing blood pressure. Hence, they are expected to be useful in the prevention and management of MetS. At present, epidemiological studies indicate a negative correlation between polyphenol intake and MetS incidence. In this review, we summarized and discussed the most promising natural polyphenols (including flavonoid and non-flavonoid drugs) in the precaution and treatment of MetS, including their anti-inflammatory and antioxidant properties, as well as their regulatory functions involved in glycolipid homeostasis.

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“…Anti-in ammatory activities of phytosomal curcumin have been reported to have positive effects in various diseases such as cancers 16 and hepatic disorders 18,19 . In addition, several studies illustrated the protective effects of phytosomal curcumin against liver brosis and non-alcoholic fatty liver diseases [20][21][22] . In this study we aim to investigate the protective effects of phytosomal curcumin on post-operative peritoneal and peritendinous adhesions.…”

Section: Introductionmentioning

confidence: 99%

Phytosomal curcumin elicits potent protective responses in post-surgical adhesion band formation by decreasing inflammation and fibrosis

Askarnia-Faal

Sayyed-Hosseinian

Nazari

et al. 2022

Preprint

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Background In this study we investigated the therapeutic potential of the phytosomal form of pharmacologically active component of Curcuma longa, curcumin, in attenuating Post-operative adhesion bands (PSAB) formation in both peritoneal and peritendinous surgeries in animal models. Methods Bio-mechanical, Histological and quantitative evaluation of inflammation, and total fibrosis scores were graded and measured in the presence and absence of phytosomal curcumin. Results Our results showed that phytosomal curcumin significantly decreased severity, length, density and tolerance of mobility of peritendinous adhesions as well as incidence and severity of abdominal fibrotic bands post-surgery. We showed that curcumin could decrease inflammation by attenuating recruitment of inflammatory cells and regulating oxidant/anti-oxidant balance in post-operative tissue samples. Moreover, markedly lower fibrosis scores were obtained in the adhesive tissues of phytosomal curcumin-treated groups which correlated with a significant decrease in quantity, quality and grading of fibers, and collagen deposition in animal models. Conclusion These results suggest that the anti-inflammatory and anti-fibrotic properties of phytosomal curcumin, has therapeutic potential for preventing PSAB formation.”

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The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial

Cited by 39 publications

References 34 publications

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications

Phytosomal curcumin elicits potent protective responses in post-surgical adhesion band formation by decreasing inflammation and fibrosis

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