The Effect Of Curcumin On Hypoxia In Tumor Microenvironment As a Regulatory Factor In Cancer
Mohammad Zahedi,
Hanieh Salmani Izadi,
Faezeh Arghidash
et al.
Abstract:Hypoxia can lead to different responses from cancer cells, including cell death or survival, partially depending on how long it is exposed. Patients with cancer and under hypoxic tumor conditions have a poorer prognosis and are at greater risk of metastasis. Physiological response to low oxygen levels is controlled by hypoxia-inducible factor (HIF-1). Curcumin, the major component of the rhizomes of Curcuma longa L., reduces HIF-1 levels and function, inhibiting the production of vascular endothelial growth fa… Show more
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