The Effect of Cumin cyminum L. Plus Lime Administration on Weight Loss and Metabolic Status in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Abstract

BackgroundLimited data are available regarding the effects of combined administration of Cumin cyminum L. and lime on weight loss and metabolic profiles among subjects with overweight subjects.ObjectivesThe current study aimed to assess the effects of combined administration of Cumin cyminum L. and lime on weight loss and metabolic profiles among subjects with overweight.Patients and MethodsThis randomized double-blind placebo-controlled clinical trial was conducted on 72 subjects with overweight, aged 18 - 50 years old. Participants were randomly divided into three groups: Group A received high-dose Cumin cyminum L. and lime capsules (75 mg each, n = 24), group B low-dose Cumin cyminum L. and lime capsules (25 mg each, n = 24) and group C placebos (n = 24) twice daily for eight weeks.ResultsAfter eight weeks of intervention, compared with low-dose C. cyminum L. plus lime and placebo, taking high-dose C. cyminum L. plus lime resulted in significant weight loss (in the high-dose group: -2.1 ± 1.7 vs. in the low-dose group: -1.2 ± 1.5 and in the placebo group: + 0.2 ± 1.3 kg, respectively; P < 0.001) and body mass index (-0.8 ± 0.6 vs. -0.5 ± 0.5 and +0.1 ± 0.5 kg/m2, respectively; P < 0.001). In addition, administration of high-dose C. cyminum L. plus lime compared with low-dose C. cyminum L. plus lime and placebo, led to a significant reduction in fasting plasma glucose (FPG) (P < 0.001) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (+ 0.02 ± 0.02 vs. + 0.01 ± 0.02 and 0.01 ± 0.01, respectively; P = 0.01). Moreover, a significant decrease in serum triglycerides (-14.1 ± 56.2 vs. +13.9 ± 36.8 and + 10.6 ± 25.1 mg/dL; respectively; P = 0.03), total-cholesterol (-18.4 ± 28.6 vs. +8.6 ± 28.5 and -1.0 ± 24.8 mg/dL; respectively; P = 0.004) and low density lipoproteins- (LDL)-cholesterol levels (-11.8 ± 20.7 vs. +6.5 ± 23.2 and -2.9 ± 20.4 mg/dL, respectively; P = 0.01) was observed following the consumption of high-dose C. cyminum L. plus lime compared with low-dose C. cyminum L. plus lime and placebo.ConclusionsResults of the current study indicated that taking high-dose C. cyminum L. plus lime for eight weeks among subjects with overweight had beneficial effects on weight, BMI, FPG, QUICKI, triglycerides, total-cholesterol and LDL-cholesterol levels.

The effect of cumin supplementation on metabolic profiles in patients with metabolic syndrome: A randomized, triple blind, placebo‐controlled clinical trial

“…In contrast to our results, Taghizadeh et al observed no significant difference in TAC levels in overweight subjects who took 300‐mg/day CuEO (Taghizadeh, Memarzadeh, Asemi, & Esmaillzadeh, ). These researchers in another study showed no significant effects of using C. cyminum L. plus lime (75 and 25 mg twice daily) on TAC and GSH levels in overweight subjects (Taghizadeh et al, ). ROS, which are induced by MetS, have a direct role in the initiation of oxidative stress, oxidation of lipids, formation of advanced glycation end products, and inflammation (Hopps et al, ).…”

Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta‐analysis of randomized controlled trials

“…In addition, cumin has widely used in the treatment a wide spectrum of diseases including dyslipidemia (Srivsatava et al, ), dyspepsia (Singh et al, ), jaundice (Mnif & Aifa, ), and diarrhoea (Sowbhagya, ). Some studies have also presented that cumin may help weight loss (Taghizadeh et al, ).…”

Obesity and Non-Alcoholic Fatty Liver - Therapies in Ayurvedic Medicines

“…BMI reduction in high dose intake was by 0.8 kg/m 2 , while low dose intake was 0.5 kg/m 2 , and placebo only 0.1 kg/m 2 . The study concluded that high dose intake of C. cyminum with lime is beneficial for weight loss and obesity treatments [17].…”

“…One randomized double-blind placebo-controlled clinical trial on the effect of Cumin cyminum L. plus Lime administration to observe weight loss and metabolic status in overweight subjects found that C. cyminum administered with lime may reduce body weight. C. cyminum inhibits serotonin re-uptake and increases levels of serotonin in synaptic clefts [17]. Limonene found in lime can reduce lipids by increasing lipolysis by histaminergic response and reduced appetite.…”

“…Limonene found in lime can reduce lipids by increasing lipolysis by histaminergic response and reduced appetite. Limonene is also anti-inflammatory and is found to improve insulin function [17]. To study the effectiveness of cumin with lime uptake, an 8-week clinical trial was conducted on 72 obese Iranian patients aged 18-50 years old ( Table 1).…”