The Effect of Cryosurgical Ablation of the Prostate on Erectile Function

Aboseif, Sherif R.; Shinohara, Katsuto; Borirakchanyavat, Sansern; Deirmenjian, J.; Carroll, Peter R.

doi:10.1016/s0022-5347(01)62989-6

Cited by 5 publications

(5 citation statements)

References 2 publications

(2 reference statements)

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“…Cryoablation has proven medium-term efficacy, with 5-and 7-year follow-up studies demonstrating biochemical disease-free survival rates comparable to those of radical surgery and radiotherapy in lowrisk patients and possibly superior in medium-and high-risk patients, with very low rates of serious morbidity. [6][7][8] However, when cryoablation is performed adequately, the combined neurovascular insult of penile arterial blood-flow impairment 16 and cavernosal-nerve damage 17 results in rates of impotence between 40% and 100%, depending on such factors as operative technique, preoperative function, and method of potency assessment. 7 Because in cryoablation the neurovascular bundles are frozen and not severed, as in radical surgery, axonal regeneration is possible.…”

Section: Discussionmentioning

confidence: 99%

Focal Prostate Cryoablation: Initial Results Show Cancer Control and Potency Preservation

Bahn

Silverman

Lee³

et al. 2006

Journal of Endourology

165

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Section: Discussionmentioning

confidence: 99%

Focal Prostate Cryoablation: Initial Results Show Cancer Control and Potency Preservation

Bahn

Silverman

Lee³

et al. 2006

Journal of Endourology

165

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show abstract

“…Most of the complications can be managed conservatively, except the "cryoshock" phenomenon, which carries a high mortality rate (18.2%). 106,140,[160][161][162] In general, the majority of complications are minor and require observation only. Complications are considered to be less severe than those of radical surgery.…”

Section: Iiid Complicationsmentioning

confidence: 99%

Thermal Therapy, Part III: Ablation Techniques

Habash

Bansal

Krewski

et al. 2007

Crit Rev Biomed Eng

117

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Ablative treatments are gaining increasing attention as an alternative to standard surgical therapies, especially for patients with contraindication or those who refuse open surgery. Thermal ablation is used in clinical applications mainly for treating heart arrhythmias, benign prostate hyperplasia, and nonoperable liver tumors; there is also increasing application to other organ sites, including the kidney, lung, and brain. Potential benefits of thermal ablation include reduced morbidity and mortality in comparison with standard surgical resection and the ability to treat nonsurgical patients. The purpose of this review is to outline and discuss the engineering principles and biological responses by which thermal ablation techniques can provide elevation of temperature in organs within the human body. Because of the individual problems associated with each type of treatment, a wide range of ablation techniques have evolved including cryoablation as well as ultrasound, radiofrequency (RF), microwave, and laser ablation. Aspects of each ablation technique, including mechanisms of action, equipment required, selection of eligible patients, treatment techniques, and patient outcomes are presented, along with a discussion of limitations of the techniques and future research directions.

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“…Aboseif and colleagues 29 have demonstrated the role of vascular injury in patients undergoing cryoablation of the prostate. Erectile function was assessed by way of prostaglandin E1 injection and high resolution Doppler ultrasonographic analysis of penile arterial flow before and 6 months after cryoablation of the prostate in 15 men.…”

Section: Cryosurgery For Prostate Cancer 1527mentioning

confidence: 99%

Single Center Experience with Third-Generation Cryosurgery for Management of Organ-Confined Prostate Cancer: Critical Evaluation of Short-Term Outcomes, Complications, and Patient Quality of Life

Hubosky

Fabrizio

Schellhammer

et al. 2007

Journal of Endourology

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Treatment success with cryosurgery varies with definition; however, our results are comparable to other series with regard to short-term cancer control. Complication rates in this series of third-generation cryosurgical patients are low. QoL characteristics of third-generation cryoablation are similar to those described in second-generation cryoablation series. Compared with brachytherapy, cryotherapy results in less irritative and obstructive voiding symptoms in the early post-treatment period and may improve urinary function up to 24 months after treatment. In a small group of older patients with baseline erectile dysfunction undergoing cryoablation, sexual function returns to 20% of its baseline value with up to 12 months follow-up.

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The Effect of Cryosurgical Ablation of the Prostate on Erectile Function

Cited by 5 publications

References 2 publications

Focal Prostate Cryoablation: Initial Results Show Cancer Control and Potency Preservation

Focal Prostate Cryoablation: Initial Results Show Cancer Control and Potency Preservation

Thermal Therapy, Part III: Ablation Techniques

Single Center Experience with Third-Generation Cryosurgery for Management of Organ-Confined Prostate Cancer: Critical Evaluation of Short-Term Outcomes, Complications, and Patient Quality of Life

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