The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats

Salahshoor, Mohammad Reza; Azari, Paria; Roshankhah, Shiva; Zokaei, Abdolhamid; Foroughinia, Azadeh

doi:10.25122/jml-2019-0144

Cited by 2 publications

(1 citation statement)

References 21 publications

(26 reference statements)

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“…The exposure to NDEA also resulted in maturation of oocyte via the polyadenylation of cyclin B mRNA as observed in the endogenous maturation induced by hormones. Collectively, NDEA disturbs and mimics the signaling pathways involved in maturation, proliferation, and cell development (Nair et al, 2017; Salahshoor et al, 2022).…”

Section: Biochemical Enzymes Affected By Ndeamentioning

confidence: 99%

A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions

Janmeda,

Jain,

Chaudhary

et al. 2024

J of Applied Toxicology

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The International Agency for Research on Cancer has classified N‐nitrosodiethylamine (NDEA) as a possible carcinogen and mutagenic substances, placing it in category 2A of compounds that are probably harmful to humans. It is found in nature and tobacco smoke, along with its precursors, and is also synthesized endogenously in the human body. The oral or parenteral administration of a minimal quantity of NDEA results in severe liver and kidney organ damage. The NDEA required bioactivation by CYP450 enzyme to form DNA adduct in the alkylation mechanism. Thus, this bioactivation directs oxidative stress and injury to cells due to the higher formation of reactive oxygen species and alters antioxidant system in tissues, whereas free radical scavengers guard the membranes from NDEA‐directed injury in many enzymes. This might be one of the reasons in the etiology of cancer that is not limited to a certain target organ but can affect various organs and organ systems. Although there are various possible approaches for the treatment of NDEA‐induced cancer, their therapeutic outcomes are still very dismal. However, several precautions were considered to be taken during handling or working with NDEA, as it considered being the best way to lower down the occurrence of NDEA‐directed cancers. The present review was designed to enlighten the general guidelines for working with NDEA, possible mechanism, to alter the antioxidant line to cause malignancy in different parts of animal body along with its protective agents. Thus, revelation to constant, unpredictable stress situations even in common life may remarkably augment the toxic potential through the rise in the oxidative stress and damage of DNA.

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Section: Biochemical Enzymes Affected By Ndeamentioning

confidence: 99%