The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study

Naamani, Kareem El; Amllay, Abdelaziz; Chen, Ching-Jen; Capone, Stephen; Abbas, Rawad; Sioutas, Georgios S; Múñoz, Alfredo; Yudkoff, Clifford J.; Carreras, Angeleah; Sambangi, Abhijeet; Hunt, Adam; Jain, Paarth; Stine, E; Sathe, Anish; Smit, Rupert D.; Yazbeck, Fouad; Tjoumakaris, Stavropoula; Gooch, M. Reid; Herial, Nabeel; Rosenwasser, Robert H.; Zarzour, Hekmat; Schmidt, Richard F.; El‐Ghanem, Mohammad; Jabbour, Pascal

doi:10.1016/j.wneu.2022.11.132

Cited by 5 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the efficacy of COVID-19 vaccines and the lack of significant associations with adverse events, clinical interest arises regarding whether COVID-19 vaccines offer protection against short-term and long-term cardiovascular and cerebrovascular events following COVID-19 infection. 24,25 Despite the declaration of the COVID-19 public health emergency being over in May 2023, 26 the persistent presence and evolving nature of the SARS-CoV-2 virus continue to burden the healthcare system globally.…”

Section: Introductionmentioning

confidence: 99%

Prior COVID‐19 vaccination and reduced risk of cerebrovascular diseases among COVID‐19 survivors

Chen,

Hsieh,

Hung

et al. 2024

Journal of Medical Virology

View full text Add to dashboard Cite

The effects of COVID‐19 vaccination on short‐term and long‐term cerebrovascular risks among COVID‐19 survivors remained unknown. We conducted a national multi‐center retrospective cohort study with 151 597 vaccinated and 151 597 unvaccinated COVID‐19 patients using the TriNetX database, from January 1, 2020 to December 31, 2023. Patients baseline characteristics were balanced with propensity score matching (PSM). The outcomes were incident cerebrovascular diseases occurred between 1st and 30th days (short‐term) after COVID‐19 diagnosis. Nine subgroup analyses were conducted to explore potential effect modifications. We performed six sensitivity analyses, including evaluation of outcomes between 1st to 180th days, accounting for competing risk, and incorporating different variant timeline to test the robustness of our results. Kaplan‐Meier curves and Log‐Rank tests were performed to evaluate survival difference. Cox proportional hazards regressions were adopted to estimate the PSM‐adjusted hazard ratios (HR). The overall short‐term cerebrovascular risks were lower in the vaccinated group compared to the unvaccinated group (HR: 0.66, 95% CI: 0.56–0.77), specifically cerebral infarction (HR: 0.62, 95% CI: 0.48–0.79), occlusion and stenosis of precerebral arteries (HR: 0.74, 95% CI: 0.53–0.98), other cerebrovascular diseases (HR: 0.57, 95% CI: 0.42–0.77), and sequelae of cerebrovascular disease (HR: 0.39, 95% CI:0.23–0.68). Similarly, the overall cerebrovascular risks were lower in those vaccinated among most subgroups. The long‐term outcomes, though slightly attenuated, were consistent (HR: 0.80, 95% CI: 0.73–0.87). Full 2‐dose vaccination was associated with a further reduced risk of cerebrovascular diseases (HR: 0.63, 95% CI: 0.50–0.80) compared to unvaccinated patients. Unvaccinated COVID‐19 survivors have significantly higher cerebrovascular risks than their vaccinated counterparts. Thus, clinicians are recommended to monitor this population closely for stroke events during postinfection follow‐up.

show abstract

Section: Introductionmentioning

confidence: 99%

Prior COVID‐19 vaccination and reduced risk of cerebrovascular diseases among COVID‐19 survivors

Chen,

Hsieh,

Hung

et al. 2024

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…contrasted the results of stroke patients who had received the COVID-19 vaccine and those who had not. 1 Although immunization did not significantly affect stroke patient outcomes at follow-up, El Naamani et al. reported that vaccination was linked to lower rates of morbidity and mortality among stroke patients upon discharge during the pandemic.…”

mentioning

confidence: 98%

“…We would like to share ideas on the publication “The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study. 1 ” El Naamani et al. contrasted the results of stroke patients who had received the COVID-19 vaccine and those who had not.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Letter to the Editor Regarding “The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study”

Kleebayoon

Wiwanitkit

2023

World Neurosurgery

View full text Add to dashboard Cite

“…Lastly, because this was a single-center study, the small cohort size was mentioned as a study limitation, and we highly encourage future collaborations or studies with larger cohort sizes to further strengthen our results. 4 …”

mentioning

confidence: 99%

In Reply to the Letter to the Editor Regarding: "The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study"

Naamani

Jabbour

2023

World Neurosurgery

View full text Add to dashboard Cite

The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study

Cited by 5 publications

References 25 publications

Prior COVID‐19 vaccination and reduced risk of cerebrovascular diseases among COVID‐19 survivors

Prior COVID‐19 vaccination and reduced risk of cerebrovascular diseases among COVID‐19 survivors

Letter to the Editor Regarding “The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study”

In Reply to the Letter to the Editor Regarding: "The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study"

Contact Info

Product

Resources

About