The Effect of Corticotrophin and Cortisone on Serum Lipids and Lipoproteins

Serum beta-lipoprotein and other specific protein concentrations in patients with immunocytoma.

“…Adlersberg et al (1950) showed a significant increase in serum cholesterol in patients receiving steroid therapy. Skanse et al (1959) furthermore showed that in short-term steroid therapy initial decrease in plasma lipids and lipoprotein levels was followed by increase affecting both triglycerides and cholesterol. However, significant increase in endogenous triglycerides in asthmatic patients receiving long-term steroid therapy was also demonstrated without changes in cholesterol levels (El-Shaboury and Hayes, 1973;Ghosh et al, 1973).…”

Hyperlipidaemia in Asthmatic Patients Receiving Long-term Steroid Therapy

“…The incidence of hypercholesterolaemia, however, was similar in both patients and controls. Adlersberg et al (1950) found that plasma cholesterol rose during treatment with steroids for several months and Skanse et al (1959) noted an initial fall in plasma cholesterol followed by a rise within a few days of starting steroids. We have not taken repeated samples for plasma lipid analysis but the mean for cholesterol values was similar in our patients and controls and steroid therapy was given for a much longer period (average of nine years).…”

“…Raised plasma cholesterol (Adlersberg et al, 1950), triglycerides, and phospholipids (Bagdade et al, 1970) were found in patients with collagen diseases treated with large doses of corticotrophin or adrenal steroids for periods of up to six months. However, treatment with steroids for several hours or days is known to cause a fall in various lipid fractions (Oliver and Boyd, 1956;Skanse et al, 1959;Moses et al, 1962;Nayak et al, 1962;Kyner et al, 1972) and this fall may be more pronounced after corticotrophin than adrenal steroids Friedman et al, 1967).…”

Total Hip Replacement in Patients With Renal Transplants

“…At present, the last theory is accepted by most investigators, as fatty liver changes and subsequent hypercholesterolemia are regular sequelae of steroid administration, and in¬ creases and decreases in steroid doses are associated with respective increases and decreases in serum lipid levels. 19,20 There have been several reports of microscopically vi¬ sualized fat microemboli in femoral head vessels in animals under such conditions. The microvascular anatomy of the subchondral zone of the femoral head appears to facilitate embolization.9,21…”