The Effect of Corticosterone and Related Compounds on the Renal Excretion of Electrolytes

Abstract

The sodium and chloride retaining effect of suprarenal cortical extracts and of crystalline compounds derived from the suprarenal cortex parallels their effectiveness in maintaining suprarenalectomized dogs. All of the active compounds thus far studied produce a potassium diuresis when injected into normal dogs. The injection of a synthetic compound, desoxy-corticosterone acetate, produced in normal dogs a very marked sodium and chloride retention and a potassium diuresis. In a suprarenalectomized dog desoxy-corticosterone acetate was substituted successfully for suprarenal cortical extract.

The Rôle of the Adrenal Cortex in Acute Anoxia 12

“…Rats were exposed to mixtures of oxygen and nitrogen in metabolism cages enclosed in glass bell-jars. 8 Samples of blood were obtained from the cut edge of the liver 9 at the time that specimens of liver and muscle were removed for glycogen determination. The FolinMalmros micro method (6) was used for the blood sugar determinations.…”

“…Rabbits as well as dogs and monkeys were exposed to mixtures of oxygen and nitrogen in metabolism cages enclosed in well ventilated glass chambers. 8 Male dogs, weighing 10 to 15 kgm. were kept in metabolism cages and fed a constant diet consisting of 350 grams of raw, ground beef to which 50 cc.…”

“…of Pet Milk was added. The technique used in the care of the dogs and in the collection of specimens has been described (8). 6 The pellets of crystalline desoxycorticosterone acetate and the desoxycorticosterone acetate in sesame oil used in this study were provided through the courtesy of Dr. E. Oppenheimer of the Ciba Pharmaceutical Products, Inc., Summit, New Jersey.…”

“…8 The mixtures of oxygen and nitrogen were circulated through the cages at a rate which was rapid enough to prevent the accumulation of over 0.5 per cent carbon dioxide. 9 The level of glucose in the blood from the cut edge of the liver was found to be the same as that in the blood obtained from the heart.…”

“…However, very low liver glycogen was noted in animals that did not have convulsions. 8. Effect of anoxia (5 hours) on normal human subjects Eight normal male subjects were exposed to an average oxygen tension of 98 mm.…”