The Effect of Copper Supplementation on Putative Indices of Body Copper Status and on Oxidative and Inflammatory Measures (Foodcue Project)

O’Connor, Jacqueline M.; Bonham, Maxine P.; Turley, E.; Kehoe, Claire A.; Coulter, James; Faughnan, Marian S.; McKeown, A.; McKelvey-Martin, V. J.; Rock, Edmond; Rayssiguier, Yves; Mazur, Andrzej; Flynn, Albert; Cashman, Kevin D.; Baker, A; Strain, Sean

doi:10.1007/0-306-47466-2_295

Cited by 2 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This present study explored serum DAO activity, a recently proposed biomarker of Cu status (DiSilvestro et al 1997;Jones et al 1997;O'Connor et al 1999), and compared it with other usual plasma indices such as plasma Cu and serum caeruloplasmin during modifications in Cu dietary intake. The potential changes were followed at day 4, 8, 12 and 18 on Cu-deficient (0⋅61 mg/kg) and Cu-supplemented diets (35 mg/kg).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, diamine oxidase (DAO), a Cu-dependent enzyme, has been proposed as a valuable biomarker of Cu status in human subjects and in animals (DiSilvestro et al 1997;Jones et al 1997;O'Connor et al 1999). DAO is an enzyme catalysing the oxidation of diamines such as histamine, putrescine and cadaverine (Wolvekamp & de Bruin, 1994).…”

Section: Copper: Diamine Oxidase: Stable Isotopesmentioning

confidence: 99%

“…DiSilvestro's group has reported high plasma DAO activities in patients undergoing renal dialysis and in some adult men receiving Cu supplementation, and low activities during spontaneous Cu deficiency (DiSilvestro et al 1997;Jones et al 1997). Moreover, the results of the European FoodCue project demonstrated high levels of plasma DAO activity with Cu supplementation in human subjects (O'Connor et al 1999). Low activities were also seen in marginally Cu-deficient rats (DiSilvestro et al 1997).…”

Section: Copper: Diamine Oxidase: Stable Isotopesmentioning

confidence: 99%

See 2 more Smart Citations

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Feillet‐Coudray¹,

Coudray²,

Bayle³

et al. 2000

Br J Nutr

Self Cite

View full text Add to dashboard Cite

There is a lack of agreement on index of Cu status and reliable and sensitive biomarkers are still required. The purpose of this present work was to assess in rats the sensitivity of diamine oxidase (DAO) activity, a recently proposed biomarker, to modifications in dietary Cu intake in comparison with other plasma biomarkers of Cu status. We also evaluated the effect of Cu dietary level on Cu and Zn intestinal absorption. Results showed that plasma Cu and plasma caeruloplasmin were significantly decreased at day 8 compared with the control group (7·4 mg Cu/kg diet) while DAO activity was significantly decreased at day 12 of the deficient diet (0·61 mg Cu/kg diet). Cu supplementation (35 mg Cu/kg diet) had no effect on any of the studied biomarkers of Cu status. In Cu-deficient rats plasma Cu and DAO activities were normalized 4 d after return to the control diet while caeruloplasmin was normalized later, at day 11. Apparent absorption values (%) of total Cu or 65Cu isotope were significantly increased in the Cu-deficient rats compared with the other groups and similar in the control and the Cu-supplemented groups. The urinary excretion of total Cu or 65Cu isotope were increased in the Cu-supplemented group compared with the other two groups. Both apparent absorption and urinary excretion of total Zn or 67Zn isotope remained unchanged in the three experimental groups. In conclusion, DAO activity seemed to be less sensitive to Cu deficiency than plasma Cu or caeruloplasmin concentrations. The present study also showed a significant increase in Cu intestinal absorption with dietary Cu restriction but no decrease with Cu supplementation in the rat.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Copper: Diamine Oxidase: Stable Isotopesmentioning

confidence: 99%

Section: Copper: Diamine Oxidase: Stable Isotopesmentioning

confidence: 99%

See 1 more Smart Citation

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Feillet‐Coudray¹,

Coudray²,

Bayle³

et al. 2000

Br J Nutr

Self Cite

View full text Add to dashboard Cite

show abstract

“… Cuproenzymes: Peptidylglycine α‐amidating monooxygenase (PAM) (Prohaska 1997; Prohaska et al 1997); Diamine oxidase (DAO) (DiSilvestro et al 1997; Jones et al 1998; O'Connor et al 2000). Its usefulness may be limited because activity is higher in females than males, elevated in response to pregnancy and some types of cancer, cystic fibrosis, uraemia, intestinal ischaemia and renal dialysis, and lower in subjects with Crohn's and coeliac diseases, and severe trauma (Failla 1999).…”

Section: Assessment Of Status/indicators Of Statusmentioning

confidence: 99%

An update on copper: contribution of MAFF‐funded research

Buttriss

Hughes

2000

Nutrition Bulletin

View full text Add to dashboard Cite

This paper summarises the findings with respect to copper of the British Nutrition Foundation's recent review of the outcomes of the Ministry of Agriculture, Fisheries and Food's Optimal Nutrition Status research programme and identifies future research requirements. The typical human adult body contains approximately 100 mg of copper (Cu), the majority of which is tightly bound to about 30 enzymes and proteins. Cu is an essential transition element that plays a fundamental role in biochemistry by permitting the transfer of electrons in critical metabolic pathways. The paper provides an overview of current knowledge about the function, sources and habitual intakes of copper in the UK; absorption, bioavailability and metabolic regulation; and assessment or indicators of human copper status. Further research requirements to determine optimal nutrition status for copper were identified in the review and refined at a workshop of experts. These have been presented to the Food Standards Agency and are included in the paper.

show abstract

The Effect of Copper Supplementation on Putative Indices of Body Copper Status and on Oxidative and Inflammatory Measures (Foodcue Project)

Cited by 2 publications

References 8 publications

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

An update on copper: contribution of MAFF‐funded research

Contact Info

Product

Resources

About