The effect of controlled drinking in alcoholic cardiomyopathy

Nicolás, J.M.; Fernández-Solà, J; Estruch, R

doi:10.1016/s1062-1458(02)00717-1

Cited by 13 publications

(14 citation statements)

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“…AD recipients also had higher E/E′ at 1 year and on their last echocardiographic study, which in conjunction with increased LVM suggests impaired cardiac allograft diastolic function. This finding suggests that alcoholic damage to the cardiac allograft may not recover even in the setting of recipient abstinence from alcohol . Older donor age is a risk factor for worse post‐HTx outcomes .…”

Section: Discussionmentioning

confidence: 99%

The effect of donor alcohol abuse on outcomes following heart transplantation

Newman

Liebo

Lowes

et al. 2019

Clinical Transplantation

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Background: Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients. Methods:Overall, 370 HTx recipients were divided into two groups: (a) the alcoholic donor group (AD, n = 58) and (b) the non-alcoholic donor group (NAD, n = 312). Results:Recipients in the AD group had a slower heart rate (86 ± 13 vs 93 ± 13, P = 0.004) and an increased incidence of early atrial fibrillation (AF) (30% vs 11%, P = 0.003). Echocardiographic left ventricular mass was higher among alcoholic donors (171.7 ± 66.7 vs 151.6 ± 54.7, P = 0.02). This difference remained present 1 year following HTx (185 ± 43 vs 166 ± 42, P = 0.007). E/E′ was higher in the AD group (9.5 ± 3.9 vs 8.4 ± 2.9, P = 0.04) and a larger number of AD recipients had a ventilatory equivalent for VCO 2 > 34 (50% vs 31%, P = 0.04) on cardiopulmonary exercise test. There was no significant difference in rejection, cardiac allograft vasculopathy (CAV), or survival between the groups. Conclusions:Our data suggest that donor AA does not impact rejection, CAV, or intermediate-term survival, but may cause increased incidence of post-HTx AF and impaired cardiac allograft diastolic function. K E Y W O R D Satrial fibrillation, diastolic dysfunction, donor characteristics, heart transplantation

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Section: Discussionmentioning

confidence: 99%

The effect of donor alcohol abuse on outcomes following heart transplantation

Newman

Liebo

Lowes

et al. 2019

Clinical Transplantation

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“…As reviewed recently, modeling studies with rats showed that chronic ethanol ingestion decreases the cardiac and skeletal muscle contents of myofibrillar and sarcoplasmic proteins, apparently by inhibition of translational but not transcriptional steps in protein synthesis (Lang et al., 2005). In humans it was shown that the development of alcoholic cardiomyopathy is functionally reduced or reversed if ethanol consumption is restricted to 60 g/day or less (Nicolas et al., 2002). Although difficult to compare precisely, the 20% ethanol in water model used here provides approximately 30% of calories (Blank et al., 1991) and appears to be calorically higher than the 60 g/day ethanol in an average human diet.…”

Section: Discussionmentioning

confidence: 99%

Thymocytes, Pre‐B Cells, and Organ Changes in a Mouse Model of Chronic Ethanol Ingestion—Absence of Subset‐Specific Glucocorticoid‐Induced Immune Cell Loss

Cook

Schlueter

Coleman

et al. 2007

Alcoholism Clin & Exp Res

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This model of ethanol administration is convenient, sustainable for up to 1 year, demonstrably feasible in several mouse strains, permits good weight gains in most strains, and results in significant changes in a number of organs. The administration method also will permit modeling of long-term steady abuse punctuated by major binges, and is suitable for supplementation studies using water soluble additives. Overall, the method is useful for a wide range of studies requiring a chronic low-stress method of ethanol administration.

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“…Alcohol consumption should be limited for all patients with HF, and if it is believed to be responsible and/or contributing to the syndrome it should be avoided altogether because there is a dose-dependent effect and individual susceptibility to the deleterious effects of alcohol. 268 Because smoking has been linked to the progression of CAD all attempts should be done to promote smoking RECOMMENDATION 71. We recommend regular exercise to improve exercise capacity, symptoms, and quality of life in all HF patients (Strong Recommendation; Moderate-Quality Evidence).…”

Section: Important Nonpharmacological and Nondevice Management Optionsmentioning

confidence: 99%

2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure

Ezekowitz

O’Meara

McDonald

et al. 2017

Canadian Journal of Cardiology

527

489

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Since the inception of the Canadian Cardiovascular Society heart failure (HF) guidelines in 2006, much has changed in the care for patients with HF. Over the past decade, the HF Guidelines Committee has published regular updates. However, because of the major changes that have occurred, the Guidelines Committee believes that a comprehensive reassessment of the HF management recommendations is presently needed, with a view to producing a full and complete set of updated guidelines. The primary and secondary Canadian Cardiovascular Society HF panel members as well as external experts have reviewed clinically relevant literature to provide guidance for the practicing clinician. The 2017 HF guidelines provide updated guidance on the diagnosis and management (self-care, pharmacologic, nonpharmacologic, device, and referral) that should aid in day-to-day decisions for caring for patients with HF. Among specific issues covered are risk scores, the differences in management for HF with preserved vs reduced ejection fraction, exercise and rehabilitation, implantable devices, revascularization, right ventricular dysfunction, anemia, and iron deficiency, cardiorenal syndrome, sleep apnea, cardiomyopathies, HF in pregnancy, cardio-oncology, and myocarditis. We devoted attention to strategies and treatments to prevent HF, to the organization of HF care, comorbidity management, as well as practical issues around the timing of referral and follow-up care. Recognition and treatment of advanced HF is another important aspect of this update, including how to select advanced therapies as well as end of life considerations. Finally, we acknowledge the remaining gaps in evidence that need to be filled by future research.

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The effect of controlled drinking in alcoholic cardiomyopathy

Cited by 13 publications

References 0 publications

The effect of donor alcohol abuse on outcomes following heart transplantation

The effect of donor alcohol abuse on outcomes following heart transplantation

Thymocytes, Pre‐B Cells, and Organ Changes in a Mouse Model of Chronic Ethanol Ingestion—Absence of Subset‐Specific Glucocorticoid‐Induced Immune Cell Loss

2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure

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