The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults

Allsopp, Philip J.; Crowe, William E.; Bahar, Bojlul; Harnedy, Pádraigín A.; Brown, Emma M.; Taylor, Sonja S.; Smyth, Thomas J.; Soler-Vila, Anna; Magee, Pamela; Gill, Chris; Strain, Conall; Hegan, Vicky; Devaney, Martin; Wallace, Julie; Cherry, Paul; Fitzgerald, Richard J.; Strain, JJ; O’Doherty, John V.; McSorley, Emeir M.

doi:10.1007/s00394-015-1011-1

Cited by 33 publications

(37 citation statements)

References 54 publications

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“…Contrary to our promising results in DIO-animals, Allsopp et al recently reported that consuming P. palmata -enriched bread stimulated inflammation, and increased serum TG and thyroid stimulating hormone (TSH) in a healthy (non-obese) people [ 50 ]. High level of iodides in P. palmata would stimulate TSH synthesis and secretion from thyroids, leading to enhanced inflammation.…”

Section: Discussioncontrasting

confidence: 98%

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

et al. 2018

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(1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases.

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Section: Discussioncontrasting

confidence: 98%

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

et al. 2018

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“…In contrast to our findings, a recent randomized placebo‐controlled intervention trial conducted in healthy adults showed that P. palmata consumption increased serum TG (Allsopp et al, 2016). In their report, the authors stated that the high temperature of the baking process might result in thermally‐induced transformation and inactivation of the beneficial n −3 fatty acids, and that some of the participants might have failed to provide fasting samples (Allsopp et al, 2016), which might explain this discrepancy, as could the differences in sample size, baseline characteristics, and administration period and dose of P. palmata . One of the limitations of the present study was that it was conducted in Japanese participants; therefore, it is unknown whether our results can be generalized to non‐Japanese populations.…”

Section: Discussioncontrasting

confidence: 99%

Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double‐blind placebo‐controlled trial

Takase

Nakamura

Miyoshi

et al. 2020

Phytotherapy Research

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Background Red algae have been reported to improve lipid and glucose metabolism in rats. We investigated the effects of Palmaria palmata (P. palmata), a red alga from northern Japan, on lipid metabolism and glycemic control in participants with hypercholesterolemia. Methods We conducted an 8‐week, randomized, double‐blind, placebo‐controlled, and parallel‐group comparison trial. The study enrolled Japanese participants with a serum low‐density protein cholesterol (LDL‐C) ≥120 mg/dL. The participants were randomly assigned to take either capsules containing P. palmata (2 g/day) or placebo capsules. The primary endpoint was the change in LDL‐C from baseline to week 8 and the secondary endpoints were the changes in other lipid parameters and glycemic control. Results Of the 104 participants completed the study protocol. There were no significant differences in change in LDL‐C, body mass index, waist circumference, or glycemic control between the two groups. However, serum triglyceride showed significantly greater improvement in women in the P. palmata group (−9.0 [−25.0, +5.0]) vs. those in the placebo group (−1.0 [−11.0, +19.0]; p = .03). Conclusions The present study did not show that P. palmata had significant effect on serum LDL‐C nor glycemic control, but hypertriglyceridemia could be ameliorated by administration of P. palmata in women.

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“…Moreover, a Palmaria palmata-enriched bread has been shown to have negative effects in terms of preventing cardiovascular disorders. In a randomized placebo-controlled trial conducted in healthy adults, the bread stimulated inflammation, increasing serum triglycerides and altering thyroid function, although these changes appeared to have negligible influence, since they remained within the normal clinical range [156].…”

Section: Cardiovascular Riskmentioning

confidence: 98%

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Azzini²,

et al. 2020

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Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.

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The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults

Cited by 33 publications

References 54 publications

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double‐blind placebo‐controlled trial

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

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