The effect of constant darkness and circadian resynchronization on the recovery of alcohol hangover

Karadayian, Analía G.; Lores‐Arnaiz, Silvia; Cutrera, Rodolfo A.

doi:10.1016/j.bbr.2014.03.048

Cited by 6 publications

(4 citation statements)

References 40 publications

(34 reference statements)

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“…Mice were acclimated to constant dark for 6 weeks, and livers were harvested at 9:00 am (CT1), and then every 4 h (CT5, CT9, CT13, CT17, and CT21). RNA-Seq data was presented as reads count of pooled samples hangover swiss mice [53]. Profiling genes circadian rhythm under L-DD is important for metabolic study.…”

Section: Discussionmentioning

confidence: 99%

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Zhang

et al. 2020

BMC Genomics

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Background: The circadian rhythms regulate physiological functions and metabolism. Circadian Time (CT) is a unit to quantify the rhythm of endogenous circadian clock, independent of light influence. To understand the gene expression changes throughout CT, C57BL/6 J mice were maintained under constant darkness (DD) for 6 weeks, and the liver samples were collected starting at 9:00 AM (CT1), and every 4 h in a 24-h cycle (CT5, CT9, CT13, CT17 and CT21). Total RNA was extracted and subjected to RNA-Seq data (deposited as GSE 133342, L-DD). To compare gene oscillation pattern under normal light-dark condition (LD, GSE114400) and short time (2 days) dark-dark condition (S-DD, GSE70497), these data were retried from GEO database, and the trimmed mean of M-values normalization was used to normalize the three RNA-seq data followed by MetaCycle analysis. Results: Approximate 12.1% of the genes under L-DD exhibited significant rhythmically expression. The top 5 biological processes enriched in L-DD oscillation genes were mRNA processing, aromatic compound catabolic process, mitochondrion organization, heterocycle catabolic process and cellular nitrogen compound mitotic catabolic process. The endogenous circadian rhythms of clock genes, P450 genes and lipid metabolism genes under L-DD were further compared with LD and S-DD. The oscillation patterns were similar but the period and amplitude of those oscillation genes were slightly altered. RT-qPCR confirmed the selected RNA sequence findings. Conclusions: This is the first study to profile oscillation gene expressions under L-DD. Our data indicate that clock genes, P450 genes and lipid metabolism genes expressed rhythmically under L-DD. Light was not the necessary factor for persisting circadian rhythm but influenced the period and amplitude of oscillation genes.

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Section: Discussionmentioning

confidence: 99%

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Zhang

et al. 2020

BMC Genomics

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“…Thus, at the same phase, circadian modulation results in decreased sensitivity to the sedative properties of alcohol and speeds the recovery process from those sedative effects. In mice, the circadian clock affects recovery from alcohol hangover symptoms, including motor coordination and anxiety, with constant darkness shortening recovery periods and circadian desynchronization inhibiting the recovery (Karadayian et al, 2014). We found that the absence of a functional circadian clock in per 01 mutants significantly increased the time necessary to recover from the sedative effects of alcohol.…”

Section: Discussionmentioning

confidence: 99%

Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila

Nobrega

Lyons

2016

J Biol Rhythms

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Delineating the factors that affect behavioral and neurological responses to alcohol is critical to facilitate measures for preventing or treating alcohol abuse. The high degree of conserved molecular and physiological processes make Drosophila melanogaster a valuable model for investigating circadian interactions with alcohol-induced behaviors and examining sex-specific differences in alcohol sensitivity. We found that wild-type Drosophila exhibit rhythms in alcohol-induced sedation under light-dark and constant dark conditions with considerably greater alcohol exposure necessary to induce sedation during the late (subjective) day and peak sensitivity to alcohol occurring during the late (subjective) night. The circadian clock also modulated the recovery from alcohol-induced sedation with flies regaining motor control significantly faster during the late (subjective) day. As predicted, the circadian rhythms in sedation and recovery were absent in flies with a mutation in the circadian gene period or arrhythmic flies housed in constant light conditions. Flies lacking a functional circadian clock were more sensitive to the effects of alcohol with significantly longer recovery times. Similar to other animals and humans, Drosophila exhibit sex-specific differences in alcohol sensitivity. We investigated whether the circadian clock modulated the rhythms in the Loss-of-Righting Reflex, alcohol-induced sedation, and recovery differently in males and females. We found that both sexes demonstrate circadian rhythms in the Loss-of-Righting Reflex and sedation with the differences in alcohol sensitivity between males and females most pronounced during the late subjective day. Recovery of motor reflexes following alcohol sedation also exhibited circadian modulation in male and female flies, although the circadian clock did not modulate the difference in recovery times between the sexes. These studies provide a framework outlining how the circadian clock modulates alcohol-induced behaviors in Drosophila and identifies sexual dimorphisms in the circadian modulation of alcohol behaviors.

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“…hangover was developed, demonstrating long-lasting motor and affective impairments for at least 14-20 h post hangover onset [46][47][48]. Based on this model, the after-effects of acute ethanol exposure were associated with an imbalance in free radical and antioxidant production, together with decreases in oxygen consumption, inhibition of respiratory chain complex enzymatic activity, and decreases in mitochondrial membrane potential in the mouse brain cortex and cerebellum [46,[49][50][51].…”

Section: Pathology and Treatmentmentioning

confidence: 99%

Proceedings of the 12th Alcohol Hangover Research Group Meeting, in Buenos Aires, Argentina

Tellez-Monnery,

Balikji,

Carrere

et al. 2024

AHRG Meeting 2022

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The effect of constant darkness and circadian resynchronization on the recovery of alcohol hangover

Cited by 6 publications

References 40 publications

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila

Proceedings of the 12th Alcohol Hangover Research Group Meeting, in Buenos Aires, Argentina

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