2008
DOI: 10.1016/j.biomaterials.2007.09.007
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The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine

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Cited by 116 publications
(64 citation statements)
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“…Moreover, GNPs are bioinert and nontoxic (30). Various GNPs functionalized with cationic quaternary ammonium (20), cationic lipid (21), chitosans (22), amino acids (23), and polyethylenimine (24) were demonstrated to be excellent vehicles for the delivery of genetic material into cells. Thomas and Klibanov covalently conjugated branched PEI of 2 kDa to GNPs and found that conjugation to GNPs greatly enhances PEI's transfer of plasmid DNA into mammalian cells (24).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, GNPs are bioinert and nontoxic (30). Various GNPs functionalized with cationic quaternary ammonium (20), cationic lipid (21), chitosans (22), amino acids (23), and polyethylenimine (24) were demonstrated to be excellent vehicles for the delivery of genetic material into cells. Thomas and Klibanov covalently conjugated branched PEI of 2 kDa to GNPs and found that conjugation to GNPs greatly enhances PEI's transfer of plasmid DNA into mammalian cells (24).…”
Section: Introductionmentioning
confidence: 99%
“…The promising properties of gold particle filled Cs matrix has also encouraged some research works to fabricate and investigate the Cs/Au composites as potential materials for drug delivery application [81]. The stabilization that was induced by Au nano particles towards Cs matrix produced a better drug loading and stability of Cs composites [92,93]. Meanwhile, the presence of Au nano particles in Cs matrix improved the radiotherapy, whereby the drug can be delivered locally to the targeted tumour sites [94,95].…”
Section: Cs/metal Biocompositesmentioning
confidence: 97%
“…Zhou et al (2008) demonstrated that gold nanoparticles conjugated with low molecular weight chitosan induce an enhanced serum antibody response ten-times more potent than naked DNA vaccine. Park et al (2013) reviewed the role of nanotechnology in the field of immunotherapy.…”
Section: Gold Nanoparticlesmentioning
confidence: 98%