The aim of this study was to evaluate the effect of rheumatic disease as a risk factor for temporomandibular disease (TMD). A total of 143 outpatients reporting symptoms indicating rheumatic disease at their first visit to the rheumatology clinic were included. We evaluated the temporomandibular joint (TMJ) with scintigraphic images, and standard questionnaires were administered for the symptomatic assessment for all patients. The patients were classified into 'healthy controls' or as per their diagnosis into 'osteoarthritis', 'axial spondyloarthritis', 'peripheral spondyloarthritis', 'rheumatoid arthritis', or 'other rheumatic diseases' groups. The patients were also differentiated depending on the presence or absence of axial involvement. The relation between the rheumatic disease type and findings at the TMJ were evaluated using statistical analyses. Axial spondyloarthritis, peripheral spondyloarthritis, and rheumatic arthritis patients showed significantly higher scintigraphic uptake at the tMJ compared with those in the control and osteoarthritis groups (axial spondyloarthritis: 4.5, peripheral spondyloarthritis: 4.5, rheumatoid arthritis: 4.09, control: 3.5, osteoarthritis: 3.4, p < 0.0001). Compared with patients without axial involvement, patients with axial involvement also showed significantly higher TMJ scintigraphic uptake (axial involvement: 4.24, without axial involvement: 3.50, p < 0.0001) with elevated symptomatic rates in TMD (axial involvement: 17.82, without axial involvement: 9.97, p < 0.005). Rheumatic diseases refer to a group of conditions with a complex immune pathophysiology affecting multiple organ systems 1. Of these, inflammatory rheumatic arthritic diseases show many systemic abnormalities along with deformities of the synovial structures 2. The temporomandibular joint (TMJ), as a synovial joint between the temporal bone and the mandible, is also involved in various rheumatic diseases including rheumatoid arthritis (RA) 3,4 , ankylosing spondylitis (AS) 5,6 , and spondyloarthritis (SpA) 7. In addition, the correlation between laboratory values of various inflammatory markers causing rheumatic diseases and the progression of TMD has been reported. Although the significantly correlated indicators differed depending upon the methods used for evaluating the joint, C-reactive protein (CRP) 8 , rheumatoid factor (RF) 8,9 , erythrocyte sedimentation rate (ESR) 9 , and disease activity score (DAS) 28 10 showed the correlation with TMJ involvement. Bone scintigraphy is a nuclear scanning test in which the uptake ratio of radiopharmaceuticals is influenced by the amount of calcium at the phosphate binding sites and the amount of blood flow to the bone 11. Since detection of inflammatory synovitis of the TMJ is an efficient way to evaluate whether the joint is affected by rheumatic disease 12 , bone scintigraphy can be effectively utilized for the purpose as a sensitive tool for the detection of inflammatory lesions and high osteoblastic activity 13. Moreover, in investigating the correlation be...