The effect of conductive aligned fibers in an injectable hydrogel on nerve tissue regeneration

Mozhdehbakhsh Mofrad, Yasaman; Shamloo, Amir

doi:10.1016/j.ijpharm.2023.123419

Cited by 8 publications

(3 citation statements)

References 113 publications

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“…The hy drogel supported the viability of human neuroblastoma cells, which were uniformly dis persed through the polymer structure (Figure 3). Mozhdehbakhsh Mofrad and Shamloo [102] produced a thermoresponsive chitosan hydrogel with conductive aligned nanofibers composed of polycaprolactone/gelatin/sin gle-wall carbon nanotubes. The biodegradable hydrogel displayed a porous structure with interconnected pores with a pore diameter and porosity of 26.3-50.9 µm and 68.3-78.7%, respectively.…”

Section: Nervous Systemmentioning

confidence: 99%

“…The hydrogel displayed biodegradable properties with a porous microstructure, mean pores size between 25 to 115 µm, and a high swelling ratio between 140.2 and 589% (Figure 4). Mozhdehbakhsh Mofrad and Shamloo [102] produced a thermoresponsive chitosan hydrogel with conductive aligned nanofibers composed of polycaprolactone/gelatin/singlewall carbon nanotubes. The biodegradable hydrogel displayed a porous structure with interconnected pores with a pore diameter and porosity of 26.3-50.9 µm and 68.3-78.7%, respectively.…”

Section: Nervous Systemmentioning

confidence: 99%

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Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

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The repair of nervous tissue is a critical research field in tissue engineering because of the degenerative process in the injured nervous system. In this review, we summarize the progress of injectable hydrogels using in vitro and in vivo studies for the regeneration and repair of nervous tissue. Traditional treatments have not been favorable for patients, as they are invasive and inefficient; therefore, injectable hydrogels are promising for the treatment of damaged tissue. This review will contribute to a better understanding of injectable hydrogels as potential scaffolds and drug delivery system for neural tissue engineering applications.

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Section: Nervous Systemmentioning

confidence: 99%

Section: Nervous Systemmentioning

confidence: 99%

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

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show abstract

“…Chemical crosslinking methods involve processes like Michael addition reactions, Schiff base reactions, click chemistry, condensation reactions, crosslinking with aldehydes, thiol-disulfide exchange, radiation crosslinking, free-radical polymerization, photo-induced crosslinking, and enzyme-mediated crosslinking. 109 In terms of design approaches, various hydrogel scaffold designs have been applied and studied in SCI tissue engineering, such as electrospun scaffolds, 110 3D bioprinted scaffolds, 111 patterned scaffolds, in-situ injectable scaffolds, 98 microfluidic fabrication, 112 and directed microstructures. 113 For injectable conductive hydrogels, the rate of gelation of the material is critical .…”

Section: Research Progress Of Conductive Hydrogelmentioning

confidence: 99%

Advances in Conductive Hydrogel for Spinal Cord Injury Repair and Regeneration

Qin,

Qi,

Pan

et al. 2023

IJN

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Spinal cord injury (SCI) treatment represents a major challenge in clinical practice. In recent years, the rapid development of neural tissue engineering technology has provided a new therapeutic approach for spinal cord injury repair. Implanting functionalized electroconductive hydrogels (ECH) in the injury area has been shown to promote axonal regeneration and facilitate the generation of neuronal circuits by reshaping the microenvironment of SCI. ECH not only facilitate intercellular electrical signaling but, when combined with electrical stimulation, enable the transmission of electrical signals to electroactive tissue and activate bioelectric signaling pathways, thereby promoting neural tissue repair. Therefore, the implantation of ECH into damaged tissues can effectively restore physiological functions related to electrical conduction. This article focuses on the dynamic pathophysiological changes in the SCI microenvironment and discusses the mechanisms of electrical stimulation/signal in the process of SCI repair. By examining electrical activity during nerve repair, we provide insights into the mechanisms behind electrical stimulation and signaling during SCI repair. We classify conductive biomaterials, and offer an overview of the current applications and research progress of conductive hydrogels in spinal cord repair and regeneration, aiming to provide a reference for future explorations and developments in spinal cord regeneration strategies.

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