The effect of conditional cash transfers on the control of neglected tropical disease: a systematic review

Ahmed, Aaminah; Aune, Dagfinn; Víneis, Paolo; Pescarini, Júlia Moreira; Millett, Christopher; Hone, Thomas

doi:10.1016/s2214-109x(22)00065-1

Cited by 17 publications

(11 citation statements)

References 41 publications

(93 reference statements)

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“…Finally, the evidence concerning ICIs remains insufficient. Available data from two projects in this study, however, coincided with trends observed by a recent review of conditional cash-transfers applied to NTDs control [ 99 ]. One is that conditional transfers appear to attain greater reach among lower socioeconomic groups but, whilst that may help to reduce health inequalities, the epidemiological contributions of those skewed effects remain unclear [ 81 ].…”

Section: Discussionsupporting

confidence: 71%

Behaviour change interventions for the control and elimination of schistosomiasis: A systematic review of evidence from low- and middle-income countries

et al. 2023

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Background For the last two decades, schistosomiasis control efforts have focussed on preventive treatment. The disease, however, still affects over 200 million people worldwide. Behaviour change (BC) interventions can strengthen control by interrupting transmission through modifying exposure behaviour (water contact) or transmission practices (open urination/defaecation); or through fostering treatment seeking or acceptance. This review examines these interventions to assess their effectiveness in modifying risk practices and affecting epidemiological trends. Methodology/Principal findings A systematic multi-database literature search (PROSPERO CRD42021252368) was conducted for peer-reviewed publications released at any time before June 2021 assessing BC interventions for schistosomiasis control in low- and middle-income countries. 2,593 unique abstracts were identified, 66 were assigned to full text review, and 32 met all inclusion criteria. A typology of intervention models was outlined according to their use of behaviour change techniques and overarching rationale: health education (HEIs), social-environmental (SEIs), physical-environmental (PEIs), and incentives-centred interventions (ICIs). Available evidence does not allow to identify which BC approach is most effective in controlling risk behaviour to prevent schistosomiasis transmission. HEIs’ impacts were observed to be limited by structural considerations, like infrastructure underdevelopment, economic obligations, socio-cultural traditions, and the natural environment. SEIs may address those challenges through participatory planning and implementation activities, which enable social structures, like governance and norms, to support BC. Their effects, however, appear context-sensitive. The importance of infrastructure investments was highlighted by intervention models. To adequately support BC, however, they require users’ inputs and complementary services. Whilst ICIs reported positive impacts on treatment uptake, there are cost-effectiveness and sustainability concerns. Evaluation studies yielded limited evidence of independent epidemiological impacts from BC, due to limited use of suitable indicators and comparators. There was indicative evidence, however, that BC projects could sustain gains through treatment campaigns. Conclusions/Significance There is a need for integrated interventions combining information provision, community-based planning, and infrastructure investments to support BC for schistosomiasis control. Programmes should carefully assess local conditions before implementation and consider that long-term support is likely needed. Available evidence indicates that BC interventions may contribute towards schistosomiasis control when accompanied by treatment activities. Further methodologically robust evidence is needed to ascertain the direct epidemiological benefits of BC.

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Section: Discussionsupporting

confidence: 71%

Behaviour change interventions for the control and elimination of schistosomiasis: A systematic review of evidence from low- and middle-income countries

et al. 2023

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“…Despite numerous efforts by global agencies to eradicate these pathogens, the incidence of cutaneous leishmaniasis and the prevalence of CD increased between 2006 and 2016 according to the Global Burden of Diseases report (Vos et al, 2017;Lin et al, 2022). The rising morbidity rates indicate how poverty may weaken entire populations by limiting access to healthcare, housing, sanitary conditions, and education, perpetuating a poverty cycle by limiting productivity and impairing physical and cognitive development (Souto et al, 2019;Ahmed et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment.

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“…The Article by Aaminah Ahmed and colleagues 6 in The Lancet Global Health presents a systematic review of what is known about the effect of conditional cash transfers on the control of NTDs. Even though the amount of available information is not overwhelming, the review included 11 studies in four countries, from three major CCT programmes, and one piloted trial, and focused on screening, incidence, or treatment outcomes of only three NTDs (leprosy, schistosomiasis, and soil-transmitted helminthiasis), the overall evidence validates the potential for CCTs to contribute to improved NTD outcomes.…”

Section: The Potential Of Conditional Cash Transfers For the Control ...mentioning

confidence: 99%

The potential of conditional cash transfers for the control of neglected tropical diseases

Engels

Elphick-Pooley²

2022

The Lancet Global Health

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The effect of conditional cash transfers on the control of neglected tropical disease: a systematic review

Cited by 17 publications

References 41 publications

Behaviour change interventions for the control and elimination of schistosomiasis: A systematic review of evidence from low- and middle-income countries

Behaviour change interventions for the control and elimination of schistosomiasis: A systematic review of evidence from low- and middle-income countries

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

The potential of conditional cash transfers for the control of neglected tropical diseases

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