The Effect of Comprehensive Infection Control Measures on the Rate of Late-Onset Bloodstream Infections in Very Low-Birth-Weight Infants

Abstract

Late-onset bloodstream infection (LOBI) is a significant problem in very low-birth-weight (VLBW) infants and can lead to increased mortality and morbidity. The incidence of LOBI in VLBW infants in our unit was >35% before 2004, much higher than 20% reported in other studies. A comprehensive infection control measure was introduced in our unit in 2005. Here we report the effects of comprehensive infection control measures on the rate of LOBI in VLBW infants. Infants in the preintervention group (born 2001 to 2004) were compared with the intervention group (born 2005 to 2008) for baseline demographics, risk factors for infection, and the rate of LOBI. LOBI was defined as a positive blood and/or cerebrospinal fluid culture after 3 days of life. Three hundred thirty-four VLBW infants were admitted to our unit during the preintervention period and 303 during the intervention period. There was no significant difference in baseline demographics and risk factors for LOBI between the two groups. The incidence of LOBI was significantly reduced from 38% before intervention to 23% after intervention ( P < 0.001). Comprehensive infection control measures significantly reduced the rate of LOBI in VLBW infants.

The impact of staffing on central venous catheter-associated bloodstream infections in preterm neonates – results of nation-wide cohort study in Germany

“…P-values less than 0.05 were considered significant. All analyses were performed using SAS (SAS Institute, Cary, NC, USA) [1-3]. In Germany, anonymised secondary data research does not require human research committee review.…”

“…Newborns with very low birthweight (VLBW) are at increased risk for developing healthcare-associated blood stream infections (BSI) [1-3]. The BSIs mostly occur on neonatal intensive care units (NICU) and are associated with the use of central venous catheters (CVC).…”

Impacto na epidemiologia da sepse tardia após a mudança do protocolo de antimicrobianos em uma UTIN de um serviço universitário

“…No presente estudo, quase um terço dos neonatos apresentaram sepse tardia, resultado compatível ao observado por outros pesquisadores que encontraram taxas variando entre 16 e 50% (FREITAS et al, 2012;PINHEIRO et al, 2009;TRAGANTE et al, 2008;WICKER et al, 2011). Do total de casos de sepse, mais da metade teve confirmação laboratorial nos três períodos estudados concordando com outras pesquisas semelhantes, nas quais a positividade de hemoculturas ficou entre 18 e 65% (COHEN-WOLKOWIEZ et al, 2009;FREITAS et al, 2012;GRAHAM et al, 2006;MEIRELES;COSTA, 2011;PINHEIRO et al, 2009).…”