The effect of composition of a polymeric coating on the biofilm formation of bacteria and filamentous fungi

Mikušová, Nikola; Nechvílová, Kateřina; Kalendová, Andréa; Hájková, Tereza; Capáková, Zdenka; Junkar, Ita; Lehocký, Marián; Mozetič, Miran; Humpolíček, Petr

doi:10.1080/00914037.2018.1429435

Cited by 3 publications

(1 citation statement)

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“…Medical devices have some important drawbacks, such as structure failure, calcifications, infections, thrombosis, etc. [2,3,4,5,6,7,8,9,10], which are most often due to incompatibility of the material surface. Polymers are widely used as biomaterials in the medical field [7,15,16,17].…”

Section: Discussionmentioning

confidence: 99%

Advanced Drug-Eluting Poly (Vinyl Chloride) Surfaces Deposited by Spin Coating

Duta

Maximov²,

Trușcă

et al. 2019

Medicina

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Background and objectives: Medical devices such as catheters are used on a large scale to treat heart and cardiovascular diseases. Unfortunately, they present some important drawbacks (structure failure, calcifications, infections, thrombosis, etc.), with the main side effects occurring due to adhesion and proliferation of bacteria and living cells on the surface of the implanted devices. The aim of this work is to modify the surface of polyvinyl chloride (PVC), an affordable biocompatible material, in order to reduce these aforementioned side effects. Materials and Methods: The surface of PVC was modified by depositing a thin layer also of PVC that incorporates an active substance, dicoumarol (a well-known anticoagulant), by spin coating process. The modified surfaces were analyzed by Fourier-transform infrared (FT-IR) microscopy, Fourier-transform infrared (FT-IR) spectroscopy, Ultraviolet-visible spectroscopy (UV-VIS), and Scanning electron microscopy (SEM) in order to determine the surface morphology and behavior. The samples were tested for Gram-positive (S. aureus ATCC 25923) and Gram-negative (P. aeruginosa ATCC 27853) standard strains from American Type Culture Collection (ATCC). Results: The material obtained had a smooth surface with a uniform distribution of dicoumarol, which is released depending on the deposition parameters. The concentration of dicoumarol at the surface of the material and also the release rate is important for the applications for which the surface modification was designed. PVC modified using the proposed method showed a good ability to prevent salt deposition and decreased the protein adhesion, and the resistance to bacterial adherence was improved compared with standard PVC.

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Section: Discussionmentioning

confidence: 99%

Advanced Drug-Eluting Poly (Vinyl Chloride) Surfaces Deposited by Spin Coating

Duta

Maximov²,

Trușcă

et al. 2019

Medicina

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Sorbents for water purification based on conjugated polymers

Sapurina¹,

Shishov²,

Ivanova³

2020

Russ. Chem. Rev.

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The sorption properties of polymers with a polyconjugated chain structure (polyaniline and polypyrrole) are considered. The molecular mechanism of sorption by these polymers of various compounds such as heavy metal ions, toxic organic compounds and micropathogens, which are the most hazardous and stubborn contaminants in water, is discussed. The use of such sorbents to purify water from micropathogens, including bacteria and viruses, is addressed for the first time. The adsorption capacity of polyconjugated polymers for these types of contaminants, the efficiency of water treatment by these sorbents and characteristics of the currently used sorbents are analyzed. The applicability of polyaniline and polypyrrole and composites based on them as high-performance versatile sorbents for water treatment is discussed, taking into account the sorbent properties such as high stability, lack of solubility, lack of toxicity and ability to be regenerated and reused. The bibliography includes 194 references.

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