The Effect of Composition and Gastric Conditions on the Self-Emulsification Process of Ibuprofen-Loaded Self-Emulsifying Drug Delivery Systems: A Microscopic and Dynamic Gastric Model Study

Mercuri, Annalisa; Passalacqua, Antonio; Wickham, Martin S. J.; Faulks, Richard M.; Craig, Duncan Q.M.; Barker, S. A.

doi:10.1007/s11095-011-0387-8

Cited by 67 publications

(36 citation statements)

References 41 publications

(54 reference statements)

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“…Mercuri et al [81] mix oil with surfactant to water in one step and observe a swelling of the organic phase which gives rise to regions of w/o microemulsions and then liquid crystalline phases at the droplet boundaries [72,81]. Eventually, fragments of such lyotropic liquid crystalline phases break off from the droplet boundary migrating into the aqueous phase, thus dissociating into fine oil droplets.…”

Section: Phase Behavior and Its Role In Phase Inversionmentioning

confidence: 99%

Phase inversion emulsification: Current understanding and applications

Perazzo

Preziosi

Guido

2015

Advances in Colloid and Interface Science

201

121

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Section: Phase Behavior and Its Role In Phase Inversionmentioning

confidence: 99%

Phase inversion emulsification: Current understanding and applications

Perazzo

Preziosi

Guido

2015

Advances in Colloid and Interface Science

201

121

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“…Various food matrices can be applied to determine their influence on the retention, release and breakdown of food particles (Kong & Singh, 2008;Kong et al, 2011). For example, a dynamic model provided a more accurate simulation of the digestion of a selfemulsifying drug delivery system in terms of droplet size than the conventional USP II dissolution apparatus (Mercuri et al, 2011). However, more studies are required to determine the utility of these systems for the evaluation of the behavior of NMs in food.…”

Section: In Vitro Non-cellular Fluid Modelsmentioning

confidence: 99%

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Venema²,

et al. 2014

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Engineered metal/mineral, lipid and biochemical macromolecule nanomaterials (NMs) have potential applications in food. Methodologies for the assessment of NM digestion and bioavailability in the gastrointestinal tract are nascent and require refinement. A working group was tasked by the International Life Sciences Institute NanoRelease Food Additive project to review existing models of the gastrointestinal tract in health and disease, and the utility of these models for the assessment of the uptake of NMs intended for food. Gastrointestinal digestion and absorption could be addressed in a tiered approach using in silico computational models, in vitro non-cellular fluid systems and in vitro cell culture models, after which the necessity of ex vivo organ culture and in vivo animal studies can be considered. Examples of NM quantification in gastrointestinal tract fluids and tissues are emerging; however, few standardized analytical techniques are available. Coupling of these techniques to gastrointestinal models, along with further standardization, will further strengthen methodologies for risk assessment.

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“…immediate release, modifi ed release, gastroretentive, self-emulsifying drug delivery system (Vardakou et al 2011b ;Mercuri et al 2009Mercuri et al , 2011. Particularly in the case of gastro-retentives, the ability to introduce sequential meal cycles (e.g.…”

Section: Pharmaceutical-based Researchmentioning

confidence: 99%

Dynamic Gastric Model (DGM)

Thuenemann

Mandalari

Rich

et al. 2015

The Impact of Food Bioactives on Health

Self Cite

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The Dynamic Gastric Model (DGM) was developed at the Institute of Food Research (Norwich, UK) to address the need for an in vitro model which could simulate both the biochemical and mechanical aspects of gastric digestion in a realistic time-dependent manner. As in the human stomach, masticated material is processed in functionally distinct zones: Within the fundus/main body of the DGM, gastric acid and enzyme secretions are introduced around the outside of the food bolus which is subjected to gentle, rhythmic massaging. Secretion rates adapt dynamically to the changing conditions within this compartment (acidifi cation, fi ll state). Portions of gastric contents are then moved into the DGM antrum where they are subjected to physiological shear and grinding forces before ejection from the machine (and subsequent separate duodenal processing).The DGM has been used extensively for both food and pharmaceutical applications, to study, for example, release and bioaccessiblity of nutrients and drugs. The system allows the use of complex food matrices (as used in in vivo studies) and processes these under physiological conditions in real-time, thereby providing a realistic tool for the simulation of human gastric digestion.

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The Effect of Composition and Gastric Conditions on the Self-Emulsification Process of Ibuprofen-Loaded Self-Emulsifying Drug Delivery Systems: A Microscopic and Dynamic Gastric Model Study

Cited by 67 publications

References 41 publications

Phase inversion emulsification: Current understanding and applications

Phase inversion emulsification: Current understanding and applications

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Dynamic Gastric Model (DGM)

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