The Effect of Complete and Partial Hypophysectomy in Adult Albino Rats on Nitrogen, Calcium and Phosphorus Metabolism

The effect of hypophysectomy on the blood calcium and phosphorus of the rat

“…There is the further complicating factor of cessation of growth in these animals. Perla & Sandberg [1936] have shown that, after hypophysectomy in the rat, not only was there a very much increased excretion of calcium but also of phosphorus. Pugsley & Anderson [1934] have also found a negative calcium balance in the rat after hypophysectomy, and noted that this was changed to a positive balance after the administration of growth hormone.…”

The Physiology and Pharmacology of the Pituitary Body.

“…An increased excretion of Ca in the urine following hypophysectomy has been observed in the rat by Perla and Sandberg (1936). The change in absolute terms was slight but represented an increase of several hundred per cent.…”

“…Friedgood and McLean (1937), however, could not observe any change in the concentration of serum phosphate of guinea pigs receiving daily injections of alkaline anterior pituitary extract for more than a week. Perla and Sandberg (1936) found that hypophysectomy accelerates the loss of P in the feces (but not in the urine) of rats. Later, a study of the effects of partial or complete hypophysectomy on the metabolism of water, Na, K, CI, and S was made in rats by Sandberg, Perla, and Holly (1937).…”

“…According to Perla and Sandberg (1936) creatinuria transiently appears in male but not in female rats after hypophysectomy.…”

“…These authors observed hypercholesterolemia after the administration of prolan or pituitary gonadotropic hormone. Perla and Sandberg (1936) observed that the excretion of N in the urine is increased by 100 per cent during the first few weeks after hypophysectomy and remains elevated for weeks later. The observations of Yokoyama (1935) indicated that, several weeks after hypophysectomy, the dog excretes considerably less total N, uric acid, and urea.…”