The Effect of Combined Use of Platelet Rich Plasma and Adipose Derived Stem Cells on Fat Graft Survival

Seyhan, Nevra; Alhan, Doğan; Ural, Ali Uğur; Unal, Armagan; Avunduk, Mustafa Cihad; Savacı, Nedim

doi:10.1097/01.prs.0000421784.16040.3e

Cited by 10 publications

(14 citation statements)

References 4 publications

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“…The addition of PRP to fat grafting has been shown to enhance graft survival through several mechanisms. Firstly, the secretion of pro‐angiogenic factors by PRP may improve early graft vascularisation and minimise ischaemic injury; secondly, the release of anti‐inflammatory cytokines is thought to have a role in preventing graft degeneration; and thirdly, PRP‐secreted factors have been shown to enhance the differentiation of preadipocytes into their mature form . The majority of human and animal studies suggest that PRP and fat cotransplantation appears to increase graft survival rates.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

Smith

Kanapathy

Khajuria³

et al. 2018

International Wound Journal

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Adipose-derived stem cells found in fat grafts may have significant healing properties. When fat is combined with autologous platelet-rich plasma (PRP), there may be enhanced healing effects due to the pro-angiogenic and anti-inflammatory effects of PRP. This study aimed to evaluate the current evidence on fat grafting in combination with PRP for wound healing to establish the efficacy of this technique. A comprehensive search in the MEDLINE, EMBASE, CENTRAL, Science Citation Index, and Google Scholar databases (to March 2017) was conducted to identify studies on fat grafting and PRP for wound healing. Case series of less than 3 cases and studies only describing harvest technique were excluded. The database identified 571 articles, of which 3 articles that used a combination of fat and PRP for wound healing (1 RCT and 2 case series) were included in this review. A total of 69 wounds in 64 patients were treated with an average wound size of 36.32cm . Of these, 67% of wounds achieved complete healing. When reported, the mean time to healing was 7.5 weeks for those who underwent a single treatment. There were no significant complications in any patients. The combination of fat grafting and PRP may achieve adequate wound healing with relatively quick wound healing time compared with standard wound management options. However, evidence is extremely limited, and further studies are required to evaluate its efficacy for wound healing.

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Section: Discussionmentioning

confidence: 99%

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

Smith

Kanapathy

Khajuria³

et al. 2018

International Wound Journal

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show abstract

“…It has been found in these studies that VEGF is the most important factor in angiogenesis [26] . When we compared the results between the rats to which we applied fat grafts and the rats to which we applied PRP+fat grafts, we also determined a significant difference in the number of mature vessels.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have shown positive effects of the application of local growth factors on the volume and survival of the fat graft [22][23][24][25] . Insulin, steroids, lidocaine, epinephrine, and selective β1 blockers have been used with fat grafts for this purpose, and positive effects on survival of the graft have been shown [26] . Mestre et al [27] stated in their review that partial resorption occurs in the adipocyte tissue in the first month, due to local hypoxia, following a fat graft, and that the resorption area becomes filled with dermatocysts and fibrous tissues.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma on Fat Grafts in the Repair of Tympanic Membrane Perforations: An Experimental Study

et al. 2018

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“…VEGF is raised in several different PRP preparation methodologies and is released consistently over several days . When PRP and ADSCs are transplanted in mice, the levels of VEGF are significantly raised compared with ADSCs or PRP alone . The synergistic effect on angiogenesis of VEGF from both PRP and fat may be a factor in combined wound‐healing benefits, although there is little literature to support this hypothesis.…”

Section: Growth Factors and Their Role In Prp And Fat Synergymentioning

confidence: 99%

The use of fat grafting and platelet‐rich plasma for wound healing: A review of the current evidence

Smith

Jell

Mosahebi

2018

International Wound Journal

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Fat grafting is becoming a common procedure in regenerative medicine because of its high content of growth factors and adipose derived stem cells (ADSCs) and the ease of harvest, safety, and low cost. The high concentration of ADSCs found in fat has the potential to differentiate into a wide range of wound‐healing cells including fibroblasts and keratinocytes as well as demonstrating proangiogenic qualities. This suggests that fat could play an important role in wound healing. However retention rates of fat grafts are highly variable due in part to inconsistent vascularisation of the transplanted fat. Furthermore, conditions such as diabetes, which have a high prevalence of chronic wounds, reduce the potency and regenerative potential of ADSCs. Platelet‐rich plasma (PRP) is an autologous blood product rich in growth factors, cell adhesion molecules, and cytokines. It has been hypothesised that PRP may have a positive effect on the survival and retention of fat grafts because of improved proliferation and differentiations of ADSCs, reduced inflammation, and improved vascularisation. There is also increasing interest in a possible synergistic effect that PRP may have on the healing potential of fat, although the evidence for this is very limited. In this review, we evaluate the evidence in both in vitro and animal studies on the mechanistic relationship between fat and PRP and how this translates to a benefit in wound healing. We also discuss future directions for both research and clinical practice on how to enhance the regenerative potential of the combination of PRP and fat.

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The Effect of Combined Use of Platelet Rich Plasma and Adipose Derived Stem Cells on Fat Graft Survival

Cited by 10 publications

References 4 publications

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

Efficacy of Platelet-Rich Plasma on Fat Grafts in the Repair of Tympanic Membrane Perforations: An Experimental Study

The use of fat grafting and platelet‐rich plasma for wound healing: A review of the current evidence

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