The Effect of Collagen Cross-Linking Procedure on the Material of Intracorneal Ring Segments

Sideroudi, Haris; Labiris, Georgios; Beobide, Amaia Soto; Voyiatzis, G.; Chrissanthopoulos, A.; Kozobolis, Vassilios

doi:10.3109/02713683.2014.941071

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…An AFM image after the creep test showed that collagen fibers were aligned in the direction that applied the stress C. In the cycle test, the whole specimen was extended by approximately 20% D, E. An AFM image after the test showed that collagen fibers were also aligned in the direction that applied the stress F. The growth of collagen fibers by the creep test was more advanced than that by the cycle test. The white arrows on the figures show the tensile direction collagen molecules, and the chemical substances produced during each cross-linking reaction have also been identified [36][37][38]. Due to the detailed understanding of the regenerative process of the tendon, it is necessary to characterize the initial process of the structural change in tendon gel specimens and the normal tendon of mice.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the cross-linking models [36][37][38], the FT-IR spectrum is explained as follows: the first cross-linking reaction is known as an aldol condensation cross-linking reaction. In this reaction, a saturated fatty acid aldehyde group (-CHO group) was formed [36], and a peak indicating the presence of the -CHO group was confirmed near 1750 cm -1 at an arrowed peak (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Appropriate Tensile Mode and Timing of Applying Tension to Promote Tendon Gel Regeneration

Kuzumaki

Yamazaki

Suzuki

et al. 2017

Tissue Eng Regen Med

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''Tendon gel'' secreted from a parent tendon is regenerated for tendon repair by applying tension. However, the details of the tensile stimulus have not been clarified. This study aimed to evaluate an appropriate tensile stimulus mode and the optimal timing of applying tension to promote tendon gel regeneration. Tendon gel was prepared using a film model method in mice and was preserved in vivo for 3, 5, and 10 days. Unlike tendon gel on day 3 or day 5, a fibrous structure developed in the tendon gel on day 10 when tension was applied. Infrared spectroscopy revealed that characteristic peaks appearing for the tendon gel on days 3 and 5 disappeared on day 10. Disappearance of the peaks indicated maturity of the tendon gel, and it showed the optimal timing for tension application to the tendon gel. The effect of tensile load on tendon gel preserved for 10 days was investigated using a tensile test, a creep test, or a cycle test. In the tensile test, tendon gel was elongated into a thin cord of collagen fibers with an increase in stress, and the maximum diameter of the collagen fiber was approximately 50 times larger than that in the normal Achilles tendon of mice. The results suggest that the diameter of the oriented collagen fiber is controllable by adjusting the applied load and the time in mature tendon gel.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Appropriate Tensile Mode and Timing of Applying Tension to Promote Tendon Gel Regeneration

Kuzumaki

Yamazaki

Suzuki

et al. 2017

Tissue Eng Regen Med

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“…Moreover in the same concept Sideroudi et al reported that CXL procedure leads to the crosslinking effect not only of the corneal collagen but of the ICRS core material as well. This finding should be taken into consideration prior to any CXL treatment of post ICRS implanted cornea 15. …”

mentioning

confidence: 84%

Corneal Crosslinking as a New Therapeutic Tool

Kozobolis¹

2014

AOVS

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“…Sideroudi et al [ 136 ] assessed the impact of corneal CXL on the material properties of ICRS. They found that an amount of riboflavin solution was absorbed into the samples of ICRS analyzed after CXL procedure.…”

Section: Combined Proceduresmentioning

confidence: 99%

Surgical Options for the Refractive Correction of Keratoconus: Myth or Reality

Fernández-Vega-Cueto

Romano

Zaldivar

et al. 2017

Journal of Ophthalmology

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Keratoconus provides a decrease of quality of life to the patients who suffer from it. The treatment used as well as the method to correct the refractive error of these patients may influence on the impact of the disease on their quality of life. The purpose of this review is to describe the evidence about the conservative surgical treatment for keratoconus aiming to therapeutic and refractive effect. The visual rehabilitation for keratoconic corneas requires addressing three concerns: halting the ectatic process, improving corneal shape, and minimizing the residual refractive error. Cross-linking can halt the disease progression, intrastromal corneal ring segments can improve the corneal shape and hence the visual quality and reduce the refractive error, PRK can correct mild-moderate refractive error, and intraocular lenses can correct from low to high refractive error associated with keratoconus. Any of these surgical options can be performed alone or combined with the other techniques depending on what the case requires. Although it could be considered that the surgical option for the refracto-therapeutic treatment of the keratoconus is a reality, controlled, randomized studies with larger cohorts and longer follow-up periods are needed to determine which refractive procedure and/or sequence are most suitable for each case.

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The Effect of Collagen Cross-Linking Procedure on the Material of Intracorneal Ring Segments

Abstract: Our results suggest crosslinking reaction in ICRS material. This should be taken into consideration prior to any CXL treatment of post ICRS-implanted cornea.

Cited by 11 publications

References 32 publications

Appropriate Tensile Mode and Timing of Applying Tension to Promote Tendon Gel Regeneration

Appropriate Tensile Mode and Timing of Applying Tension to Promote Tendon Gel Regeneration

Corneal Crosslinking as a New Therapeutic Tool

Surgical Options for the Refractive Correction of Keratoconus: Myth or Reality

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