The effect of coenzyme Q10 on the pharmacokinetic parameters of theophylline

Baskaran, Rengarajan; Shanmugam, Sumathi; Nagayya-Sriraman, Santhoshkumar; Kim, Ju Hyun; Jeong, Tae Chun; Yong, Chul Soon; Choi, Hyun Seok; Yoo, Bong Kyu

doi:10.1007/s12272-001-1250-1

Cited by 9 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study examined relatively short-term effects of CoQ 10 administration. Longer term CoQ 10 supplementation could have some safety concerns, as CoQ 10 could precipitate drug-drug interactions—in animal studies, CoQ 10 supplementation has been shown to affect metabolism of theophylline [ 26 ], and in vitro , affect transport by P-glycoprotein, an intestinal drug transporter [ 27 ]. CoQ 10 supplementation could also alter the oral bioavailability of digoxin and verapamil, both P-glycoprotein substrates.…”

Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress

et al. 2015

View full text Add to dashboard Cite

BackgroundCoenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity in patients with congestive heart failure. There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ10 in chronic hemodialysis patients, a population subject to increased oxidative stress.MethodsWe performed a dose escalation study to test the hypothesis that CoQ10 therapy is safe, well-tolerated, and improves biomarkers of oxidative stress in patients receiving hemodialysis therapy. Plasma concentrations of F2-isoprostanes and isofurans were measured to assess systemic oxidative stress and plasma CoQ10 concentrations were measured to determine dose, concentration and response relationships.ResultsFifteen of the 20 subjects completed the entire dose escalation sequence. Mean CoQ10 levels increased in a linear fashion from 704 ± 286 ng/mL at baseline to 4033 ± 1637 ng/mL, and plasma isofuran concentrations decreased from 141 ± 67.5 pg/mL at baseline to 72.2 ± 37.5 pg/mL at the completion of the study (P = 0.003 vs. baseline and P < 0.001 for the effect of dose escalation on isofurans). Plasma F2-isoprostane concentrations did not change during the study.ConclusionsCoQ10 supplementation at doses as high as 1800 mg per day was safe in all subjects and well-tolerated in most. Short-term daily CoQ10 supplementation decreased plasma isofuran concentrations in a dose dependent manner. CoQ10 supplementation may improve mitochondrial function and decrease oxidative stress in patients receiving hemodialysis.Trial RegistrationThis clinical trial was registered on clinicaltrials.gov [NCT00908297] on May 21, 2009.

show abstract

Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Specifically, the authors found that pentagalloylglucose, which is a component of tannic acid, was able to interfere with the CoQ10 pathway: At low concentration inhibiting the electron transport system, while at high concentration impairing the structural integrity of the mitochondrial membrane. Consistently, CoQ10 was found to affect the pharmacokinetic parameters of theophylline [27], an alkaloid of the xanthine family.…”

Section: Resultsmentioning

confidence: 69%

LC-QTOF/MS Untargeted Metabolomics of Sheep Milk under Cocoa Husks Enriched Diet

Manis¹,

Scano²,

Nudda

et al. 2021

Dairy

View full text Add to dashboard Cite

The aim of this work was to evaluate, by an untargeted metabolomics approach, changes of milk metabolites induced by the replacement of soybean hulls with cocoa husks in the ewes’ diet. Animals were fed with a soybean diet integrated with 50 or 100 g/d of cacao husks. Milk samples were analyzed by an ultra high performance liquid chromatograph coupled to a time of flight mass spectrometer (UHPLC-QTOF-MS) platform. Multivariate statistical analysis showed that the time of sampling profoundly affected metabolite levels, while differences between treatments were evident at the fourth week of sampling. Cocoa husks seem to induce level changes of milk metabolites implicated in the thyroid hormone metabolism and ubiquinol-10 biosynthesis.

show abstract

“…Th e time to achieve maximum plasma concentrations is signifi cantly prolonged. Th e maximum concentrations of theophylline in plasma and AUC concentration were increased by about 100% [47].…”

Section: Coenzyme Q-10mentioning

confidence: 97%

Interactions of medicines with dietic supplementsa

Djakovic-Svajcer¹

2017

Hosp Pharm Int Multi J

View full text Add to dashboard Cite

SUMMARYIntroduction: The widespread use of drugs in patients with diff erent nutritional status, dietary habits, diet and dietary supplements creates an opportunity for the potentially unlimited numbers of interactions between medicines and food. Consequently, clinically signifi cant manifestations of those interactions should not be ignored. Corresponding section headings: Many drugs contain ingredients that react with the human organism in diff erent ways. Dietary habits and lifestyle can sometimes significantly aff ect pharmacological properties of drugs. Interactions of drugs and dietary supplements can have a signifi cant impact on the success of the therapy. Conclusion: This kind of interaction is often forgotten when medication is prescribed, so the patient is usually not aware that eating habits, with given medication, can harm health. The result of these interactions in relation to the eff ects of drugs can be positive or negative, but it is often very signifi cant.

show abstract

The effect of coenzyme Q10 on the pharmacokinetic parameters of theophylline

Cited by 9 publications

References 30 publications

Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress

Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress

LC-QTOF/MS Untargeted Metabolomics of Sheep Milk under Cocoa Husks Enriched Diet

Interactions of medicines with dietic supplementsa

Contact Info

Product

Resources

About